Immunopathogenesis of spondyloarthropathies – Concept of major histocompatibility locus-I-opathy
Spondyloarthropathies (SpA) are a group of overlapping disorders sharing certain common clinical features and genetic associations. Historically, most of the research into the pathogenesis of SpA and other types of chronic arthritis have conventionally focused on the adaptive immune system. However,...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2021-01-01
|
| Series: | Indian Journal of Rheumatology |
| Subjects: | |
| Online Access: | http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2021;volume=16;issue=4;spage=422;epage=426;aulast=Datta |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832569198572732416 |
|---|---|
| author | Amlan Kusum Datta Uddalak Chakraborty Swati Kumar Atanu Chandra |
| author_facet | Amlan Kusum Datta Uddalak Chakraborty Swati Kumar Atanu Chandra |
| author_sort | Amlan Kusum Datta |
| collection | DOAJ |
| description | Spondyloarthropathies (SpA) are a group of overlapping disorders sharing certain common clinical features and genetic associations. Historically, most of the research into the pathogenesis of SpA and other types of chronic arthritis have conventionally focused on the adaptive immune system. However, recently, the pendulum has shifted in favor of innate immunity. With an aim to explore bridging concept of major histocompatibility locus (MHC)-I-opathy in context of immunopathogenesis of SpA, MEDLINE and PubMed (2000-2019) databases were searched for English language articles using keywords “MHC-I-opathy” and “spondyloarthropathy.” We reviewed papers which addressed the concept of overlap between innate and adaptive immunity and interplay between local tissue factors and innate cellular responses in the pathogenesis of SpA. The term “MHC-I-opathy” encompasses of a group of diseases which exhibit interaction between tissue-specific factors and innate immune cells. Further studies are needed for understanding of its therapeutic implication in such diseases. |
| format | Article |
| id | doaj-art-7b37f536f9e0403d99b27c3f66083216 |
| institution | Kabale University |
| issn | 0973-3698 0973-3701 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Indian Journal of Rheumatology |
| spelling | doaj-art-7b37f536f9e0403d99b27c3f660832162025-02-02T22:47:46ZengSAGE PublishingIndian Journal of Rheumatology0973-36980973-37012021-01-0116442242610.4103/injr.injr_295_20Immunopathogenesis of spondyloarthropathies – Concept of major histocompatibility locus-I-opathyAmlan Kusum DattaUddalak ChakrabortySwati KumarAtanu ChandraSpondyloarthropathies (SpA) are a group of overlapping disorders sharing certain common clinical features and genetic associations. Historically, most of the research into the pathogenesis of SpA and other types of chronic arthritis have conventionally focused on the adaptive immune system. However, recently, the pendulum has shifted in favor of innate immunity. With an aim to explore bridging concept of major histocompatibility locus (MHC)-I-opathy in context of immunopathogenesis of SpA, MEDLINE and PubMed (2000-2019) databases were searched for English language articles using keywords “MHC-I-opathy” and “spondyloarthropathy.” We reviewed papers which addressed the concept of overlap between innate and adaptive immunity and interplay between local tissue factors and innate cellular responses in the pathogenesis of SpA. The term “MHC-I-opathy” encompasses of a group of diseases which exhibit interaction between tissue-specific factors and innate immune cells. Further studies are needed for understanding of its therapeutic implication in such diseases.http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2021;volume=16;issue=4;spage=422;epage=426;aulast=Dattaarthritisaxial spondyloarthropathieshuman leucocyte antigen b27immunologymajor histocompatibility locus |
| spellingShingle | Amlan Kusum Datta Uddalak Chakraborty Swati Kumar Atanu Chandra Immunopathogenesis of spondyloarthropathies – Concept of major histocompatibility locus-I-opathy Indian Journal of Rheumatology arthritis axial spondyloarthropathies human leucocyte antigen b27 immunology major histocompatibility locus |
| title | Immunopathogenesis of spondyloarthropathies – Concept of major histocompatibility locus-I-opathy |
| title_full | Immunopathogenesis of spondyloarthropathies – Concept of major histocompatibility locus-I-opathy |
| title_fullStr | Immunopathogenesis of spondyloarthropathies – Concept of major histocompatibility locus-I-opathy |
| title_full_unstemmed | Immunopathogenesis of spondyloarthropathies – Concept of major histocompatibility locus-I-opathy |
| title_short | Immunopathogenesis of spondyloarthropathies – Concept of major histocompatibility locus-I-opathy |
| title_sort | immunopathogenesis of spondyloarthropathies concept of major histocompatibility locus i opathy |
| topic | arthritis axial spondyloarthropathies human leucocyte antigen b27 immunology major histocompatibility locus |
| url | http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2021;volume=16;issue=4;spage=422;epage=426;aulast=Datta |
| work_keys_str_mv | AT amlankusumdatta immunopathogenesisofspondyloarthropathiesconceptofmajorhistocompatibilitylocusiopathy AT uddalakchakraborty immunopathogenesisofspondyloarthropathiesconceptofmajorhistocompatibilitylocusiopathy AT swatikumar immunopathogenesisofspondyloarthropathiesconceptofmajorhistocompatibilitylocusiopathy AT atanuchandra immunopathogenesisofspondyloarthropathiesconceptofmajorhistocompatibilitylocusiopathy |