Toxicity of antimony in housefly after whole-life-cycle exposure: Changes in growth, development, redox homeostasis, mitochondrial function, and fecundity
The increasing utilization of antimony (Sb) in manufacturing industries has led to the emergence of Sb contamination in the environment as a significant public health concern. To elucidate the toxicity of Sb and its mechanism of action, this study aimed to investigate the adverse effects of Sb on a...
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Elsevier
2025-01-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651324017329 |
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| author | Yuming Zhang Jinghua Lv Xiaoli Sun Yiwen Zhang Menghua Shao Bingbing Shi Yajie Zhang Jihai Gu Chenchen Zhao Fengsong Liu |
| author_facet | Yuming Zhang Jinghua Lv Xiaoli Sun Yiwen Zhang Menghua Shao Bingbing Shi Yajie Zhang Jihai Gu Chenchen Zhao Fengsong Liu |
| author_sort | Yuming Zhang |
| collection | DOAJ |
| description | The increasing utilization of antimony (Sb) in manufacturing industries has led to the emergence of Sb contamination in the environment as a significant public health concern. To elucidate the toxicity of Sb and its mechanism of action, this study aimed to investigate the adverse effects of Sb on a cosmopolitan insect, housefly (Musca domestica), under a whole life cycle (from embryonic to adult stage) exposure through the examination of a suite of parameters, including biological, physiological, behavioral, and molecular endpoints. A range of Sb concentrations, including moderate contamination (0.07 mM), heavy contamination (0.7 mM), and extreme contamination (7 and 70 mM), were conducted in the study. The results indicated that the houseflies could maintain their health when exposed to 0.07 mM Sb. The exposure of Sb (0.7–70 mM) to houseflies resulted in a range of adverse effects, including developmental retardation, locomotor inhibition, gut damage, oxidative stress, and mitochondrial dysfunction in the houseflies. Significantly, Sb demonstrated reproductive toxicity in the houseflies, as evidenced by reduced reproductive capacity, DNA damage, and ovarian abnormalities. The disturbance of hormonal synthesis and the MAPK pathway induced by Sb treatment may contribute to reproductive toxicity. These comprehensive toxicological data provide insight into the prediction of toxicity and the assessment of the ecological risk of Sb. |
| format | Article |
| id | doaj-art-7b2f2cf82f8b4c29a3c149bcc8623782 |
| institution | Kabale University |
| issn | 0147-6513 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-7b2f2cf82f8b4c29a3c149bcc86237822025-01-23T05:25:59ZengElsevierEcotoxicology and Environmental Safety0147-65132025-01-01289117656Toxicity of antimony in housefly after whole-life-cycle exposure: Changes in growth, development, redox homeostasis, mitochondrial function, and fecundityYuming Zhang0Jinghua Lv1Xiaoli Sun2Yiwen Zhang3Menghua Shao4Bingbing Shi5Yajie Zhang6Jihai Gu7Chenchen Zhao8Fengsong Liu9Key Laboratory of Zoological Systematics and Application, College of Life Sciences, Hebei University, Baoding 071002, ChinaKey Laboratory of Zoological Systematics and Application, College of Life Sciences, Hebei University, Baoding 071002, ChinaKey Laboratory of Zoological Systematics and Application, College of Life Sciences, Hebei University, Baoding 071002, ChinaKey Laboratory of Zoological Systematics and Application, College of Life Sciences, Hebei University, Baoding 071002, ChinaKey Laboratory of Zoological Systematics and Application, College of Life Sciences, Hebei University, Baoding 071002, ChinaKey Laboratory of Zoological Systematics and Application, College of Life Sciences, Hebei University, Baoding 071002, ChinaKey Laboratory of Zoological Systematics and Application, College of Life Sciences, Hebei University, Baoding 071002, ChinaKey Laboratory of Zoological Systematics and Application, College of Life Sciences, Hebei University, Baoding 071002, ChinaKey Laboratory of Zoological Systematics and Application, College of Life Sciences, Hebei University, Baoding 071002, ChinaCorresponding author.; Key Laboratory of Zoological Systematics and Application, College of Life Sciences, Hebei University, Baoding 071002, ChinaThe increasing utilization of antimony (Sb) in manufacturing industries has led to the emergence of Sb contamination in the environment as a significant public health concern. To elucidate the toxicity of Sb and its mechanism of action, this study aimed to investigate the adverse effects of Sb on a cosmopolitan insect, housefly (Musca domestica), under a whole life cycle (from embryonic to adult stage) exposure through the examination of a suite of parameters, including biological, physiological, behavioral, and molecular endpoints. A range of Sb concentrations, including moderate contamination (0.07 mM), heavy contamination (0.7 mM), and extreme contamination (7 and 70 mM), were conducted in the study. The results indicated that the houseflies could maintain their health when exposed to 0.07 mM Sb. The exposure of Sb (0.7–70 mM) to houseflies resulted in a range of adverse effects, including developmental retardation, locomotor inhibition, gut damage, oxidative stress, and mitochondrial dysfunction in the houseflies. Significantly, Sb demonstrated reproductive toxicity in the houseflies, as evidenced by reduced reproductive capacity, DNA damage, and ovarian abnormalities. The disturbance of hormonal synthesis and the MAPK pathway induced by Sb treatment may contribute to reproductive toxicity. These comprehensive toxicological data provide insight into the prediction of toxicity and the assessment of the ecological risk of Sb.http://www.sciencedirect.com/science/article/pii/S0147651324017329AntimonyFecundityMusca domesticaMitochondrial dysfunctionOxidative stress |
| spellingShingle | Yuming Zhang Jinghua Lv Xiaoli Sun Yiwen Zhang Menghua Shao Bingbing Shi Yajie Zhang Jihai Gu Chenchen Zhao Fengsong Liu Toxicity of antimony in housefly after whole-life-cycle exposure: Changes in growth, development, redox homeostasis, mitochondrial function, and fecundity Ecotoxicology and Environmental Safety Antimony Fecundity Musca domestica Mitochondrial dysfunction Oxidative stress |
| title | Toxicity of antimony in housefly after whole-life-cycle exposure: Changes in growth, development, redox homeostasis, mitochondrial function, and fecundity |
| title_full | Toxicity of antimony in housefly after whole-life-cycle exposure: Changes in growth, development, redox homeostasis, mitochondrial function, and fecundity |
| title_fullStr | Toxicity of antimony in housefly after whole-life-cycle exposure: Changes in growth, development, redox homeostasis, mitochondrial function, and fecundity |
| title_full_unstemmed | Toxicity of antimony in housefly after whole-life-cycle exposure: Changes in growth, development, redox homeostasis, mitochondrial function, and fecundity |
| title_short | Toxicity of antimony in housefly after whole-life-cycle exposure: Changes in growth, development, redox homeostasis, mitochondrial function, and fecundity |
| title_sort | toxicity of antimony in housefly after whole life cycle exposure changes in growth development redox homeostasis mitochondrial function and fecundity |
| topic | Antimony Fecundity Musca domestica Mitochondrial dysfunction Oxidative stress |
| url | http://www.sciencedirect.com/science/article/pii/S0147651324017329 |
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