AZD8055 Is More Effective Than Rapamycin in Inhibiting Proliferation and Promoting Mitochondrial Clearance in Erythroid Differentiation
Conclusion: AZD8055 is more effective than rapamycin in inhibiting proliferation and promoting mitochondrial clearance in erythroid differentiation, which might provide us one more therapeutic option other than rapamycin for ineffective erythropoiesis treatment in the future. These findings also pro...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2024-01-01
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| Series: | Analytical Cellular Pathology |
| Online Access: | http://dx.doi.org/10.1155/2024/2639464 |
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| _version_ | 1832557971384565760 |
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| author | Qian Liu Tao Hao Ze Lin Yipeng Fang Lei Li Daqi Huang Jianbo Wu Yanchao Zhao Xin Zhang |
| author_facet | Qian Liu Tao Hao Ze Lin Yipeng Fang Lei Li Daqi Huang Jianbo Wu Yanchao Zhao Xin Zhang |
| author_sort | Qian Liu |
| collection | DOAJ |
| description | Conclusion: AZD8055 is more effective than rapamycin in inhibiting proliferation and promoting mitochondrial clearance in erythroid differentiation, which might provide us one more therapeutic option other than rapamycin for ineffective erythropoiesis treatment in the future. These findings also provide some preliminary information indicating the roles of mTORC1 and mTORC2 in erythropoiesis, and further studies are necessary to dissect the underlying mechanisms. |
| format | Article |
| id | doaj-art-7b2a03a204804a20ae9b3427e6172947 |
| institution | Kabale University |
| issn | 2210-7185 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Analytical Cellular Pathology |
| spelling | doaj-art-7b2a03a204804a20ae9b3427e61729472025-02-03T01:38:16ZengWileyAnalytical Cellular Pathology2210-71852024-01-01202410.1155/2024/2639464AZD8055 Is More Effective Than Rapamycin in Inhibiting Proliferation and Promoting Mitochondrial Clearance in Erythroid DifferentiationQian Liu0Tao Hao1Ze Lin2Yipeng Fang3Lei Li4Daqi Huang5Jianbo Wu6Yanchao Zhao7Xin Zhang8Department of CardiologyDepartment of Colorectal and Anal SurgeryShantou University Medical CollegeDepartment of Critical Care MedicineDepartment of CardiologyDepartment of CardiologyDepartment of CardiologyBinzhou Health CommissionShantou University Medical CollegeConclusion: AZD8055 is more effective than rapamycin in inhibiting proliferation and promoting mitochondrial clearance in erythroid differentiation, which might provide us one more therapeutic option other than rapamycin for ineffective erythropoiesis treatment in the future. These findings also provide some preliminary information indicating the roles of mTORC1 and mTORC2 in erythropoiesis, and further studies are necessary to dissect the underlying mechanisms.http://dx.doi.org/10.1155/2024/2639464 |
| spellingShingle | Qian Liu Tao Hao Ze Lin Yipeng Fang Lei Li Daqi Huang Jianbo Wu Yanchao Zhao Xin Zhang AZD8055 Is More Effective Than Rapamycin in Inhibiting Proliferation and Promoting Mitochondrial Clearance in Erythroid Differentiation Analytical Cellular Pathology |
| title | AZD8055 Is More Effective Than Rapamycin in Inhibiting Proliferation and Promoting Mitochondrial Clearance in Erythroid Differentiation |
| title_full | AZD8055 Is More Effective Than Rapamycin in Inhibiting Proliferation and Promoting Mitochondrial Clearance in Erythroid Differentiation |
| title_fullStr | AZD8055 Is More Effective Than Rapamycin in Inhibiting Proliferation and Promoting Mitochondrial Clearance in Erythroid Differentiation |
| title_full_unstemmed | AZD8055 Is More Effective Than Rapamycin in Inhibiting Proliferation and Promoting Mitochondrial Clearance in Erythroid Differentiation |
| title_short | AZD8055 Is More Effective Than Rapamycin in Inhibiting Proliferation and Promoting Mitochondrial Clearance in Erythroid Differentiation |
| title_sort | azd8055 is more effective than rapamycin in inhibiting proliferation and promoting mitochondrial clearance in erythroid differentiation |
| url | http://dx.doi.org/10.1155/2024/2639464 |
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