Successful Treatment of Candida parapsilosis Fungemia in Two Preterms with Voriconazole
Herein, we report two preterms with invasive candidiasis refractory to liposomal amphotericin B (AMB) treatment in spite of low MIC levels (MIC: 0.5 mcg/mL). Both of the patients’ blood cultures were persistently positive for C. parapsilosis despite high therapeutic doses (AMB: 7 mg/kg per day). Aft...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Case Reports in Pediatrics |
| Online Access: | http://dx.doi.org/10.1155/2015/402137 |
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| author | Emel Altuncu Hulya Bilgen Ahmet Soysal Eren Ozek |
| author_facet | Emel Altuncu Hulya Bilgen Ahmet Soysal Eren Ozek |
| author_sort | Emel Altuncu |
| collection | DOAJ |
| description | Herein, we report two preterms with invasive candidiasis refractory to liposomal amphotericin B (AMB) treatment in spite of low MIC levels (MIC: 0.5 mcg/mL). Both of the patients’ blood cultures were persistently positive for C. parapsilosis despite high therapeutic doses (AMB: 7 mg/kg per day). After starting voriconazole blood cultures became negative and both of the patients were treated successfully without any side effects. In conclusion, although it is not a standard treatment in neonatal patients, our limited experience with these patients suggests that voriconazole appears to be a safe antifungal agent to be used in critically ill preterm infants with persistent fungemia despite AMB treatment. |
| format | Article |
| id | doaj-art-7b29d3fc558447bdbf5bd456329b5cee |
| institution | Kabale University |
| issn | 2090-6803 2090-6811 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pediatrics |
| spelling | doaj-art-7b29d3fc558447bdbf5bd456329b5cee2025-02-03T05:52:17ZengWileyCase Reports in Pediatrics2090-68032090-68112015-01-01201510.1155/2015/402137402137Successful Treatment of Candida parapsilosis Fungemia in Two Preterms with VoriconazoleEmel Altuncu0Hulya Bilgen1Ahmet Soysal2Eren Ozek3Division of Neonatology, Department of Pediatrics, Faculty of Medicine, Marmara University, 34890 Istanbul, TurkeyDivision of Neonatology, Department of Pediatrics, Faculty of Medicine, Marmara University, 34890 Istanbul, TurkeyDivision of Pediatric Infectious Disease, Department of Pediatrics, Faculty of Medicine, Marmara University, 34890 Istanbul, TurkeyDivision of Neonatology, Department of Pediatrics, Faculty of Medicine, Marmara University, 34890 Istanbul, TurkeyHerein, we report two preterms with invasive candidiasis refractory to liposomal amphotericin B (AMB) treatment in spite of low MIC levels (MIC: 0.5 mcg/mL). Both of the patients’ blood cultures were persistently positive for C. parapsilosis despite high therapeutic doses (AMB: 7 mg/kg per day). After starting voriconazole blood cultures became negative and both of the patients were treated successfully without any side effects. In conclusion, although it is not a standard treatment in neonatal patients, our limited experience with these patients suggests that voriconazole appears to be a safe antifungal agent to be used in critically ill preterm infants with persistent fungemia despite AMB treatment.http://dx.doi.org/10.1155/2015/402137 |
| spellingShingle | Emel Altuncu Hulya Bilgen Ahmet Soysal Eren Ozek Successful Treatment of Candida parapsilosis Fungemia in Two Preterms with Voriconazole Case Reports in Pediatrics |
| title | Successful Treatment of Candida parapsilosis Fungemia in Two Preterms with Voriconazole |
| title_full | Successful Treatment of Candida parapsilosis Fungemia in Two Preterms with Voriconazole |
| title_fullStr | Successful Treatment of Candida parapsilosis Fungemia in Two Preterms with Voriconazole |
| title_full_unstemmed | Successful Treatment of Candida parapsilosis Fungemia in Two Preterms with Voriconazole |
| title_short | Successful Treatment of Candida parapsilosis Fungemia in Two Preterms with Voriconazole |
| title_sort | successful treatment of candida parapsilosis fungemia in two preterms with voriconazole |
| url | http://dx.doi.org/10.1155/2015/402137 |
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