Circulating Cytokines and Growth Factors in Pediatric Pulmonary Hypertension
Background. Management of pediatric pulmonary hypertension (PH) remains challenging. We have assessed a panel of circulating proteins in children with PH to investigate their value as predictive and/or prognostic biomarkers. From these determinations, we aim to develop a practical, noninvasive tool...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2012/143428 |
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| _version_ | 1832545447364788224 |
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| author | Mark Duncan Brandie D. Wagner Keri Murray Jenna Allen Kelley Colvin Frank J. Accurso D. Dunbar Ivy |
| author_facet | Mark Duncan Brandie D. Wagner Keri Murray Jenna Allen Kelley Colvin Frank J. Accurso D. Dunbar Ivy |
| author_sort | Mark Duncan |
| collection | DOAJ |
| description | Background. Management of pediatric pulmonary hypertension (PH) remains challenging. We have assessed a panel of circulating proteins in children with PH to investigate their value as predictive and/or prognostic biomarkers. From these determinations, we aim to develop a practical, noninvasive tool to aid in the management of pediatric PH. Methods. Twelve cytokines and growth factors putatively associated with lung or vascular disease were examined in plasma specimens from 70 children with PH using multiplex protein array technology. Associations between hemodynamics, adverse events, and protein markers were evaluated. Results. Epidermal growth factor (EGF) and IL-6 were associated with important hemodynamics. Of the twelve proteins, VEGF and IL-6 were significantly, univariately associated with the occurrence of an adverse event, with odds ratios (95% confidence intervals) of 0.56 (0.33–0.98) and 1.69 (1.03–2.77), respectively. When hemodynamic predictors were combined with protein markers, the ability to predict adverse outcomes within the following year significantly increased. Conclusions. Specific circulating proteins are associated with hemodynamic variables in pediatric PH. If confirmed in additional cohorts, measurement of these proteins could aid patient care and design of clinical trials by identifying patients at risk for adverse events. These findings also further support a role for inflammation in pediatric PH. |
| format | Article |
| id | doaj-art-7b247da16bf24af4aaf51dc13d161ebc |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-7b247da16bf24af4aaf51dc13d161ebc2025-02-03T07:25:53ZengWileyMediators of Inflammation0962-93511466-18612012-01-01201210.1155/2012/143428143428Circulating Cytokines and Growth Factors in Pediatric Pulmonary HypertensionMark Duncan0Brandie D. Wagner1Keri Murray2Jenna Allen3Kelley Colvin4Frank J. Accurso5D. Dunbar Ivy6Section of Pediatric Pulmonology, School of Medicine, University of Colorado and Children’s Hospital Colorado, Aurora, CO 80045, USADepartment of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado Denver, Aurora, CO 80045, USASection of Pediatric Pulmonology, School of Medicine, University of Colorado and Children’s Hospital Colorado, Aurora, CO 80045, USASection of Pediatric Pulmonology, School of Medicine, University of Colorado and Children’s Hospital Colorado, Aurora, CO 80045, USASection of Pediatric Cardiology, School of Medicine, University of Colorado and Children’s Hospital Colorado, Aurora, Colorado 80045, USASection of Pediatric Pulmonology, School of Medicine, University of Colorado and Children’s Hospital Colorado, Aurora, CO 80045, USASection of Pediatric Cardiology, School of Medicine, University of Colorado and Children’s Hospital Colorado, Aurora, Colorado 80045, USABackground. Management of pediatric pulmonary hypertension (PH) remains challenging. We have assessed a panel of circulating proteins in children with PH to investigate their value as predictive and/or prognostic biomarkers. From these determinations, we aim to develop a practical, noninvasive tool to aid in the management of pediatric PH. Methods. Twelve cytokines and growth factors putatively associated with lung or vascular disease were examined in plasma specimens from 70 children with PH using multiplex protein array technology. Associations between hemodynamics, adverse events, and protein markers were evaluated. Results. Epidermal growth factor (EGF) and IL-6 were associated with important hemodynamics. Of the twelve proteins, VEGF and IL-6 were significantly, univariately associated with the occurrence of an adverse event, with odds ratios (95% confidence intervals) of 0.56 (0.33–0.98) and 1.69 (1.03–2.77), respectively. When hemodynamic predictors were combined with protein markers, the ability to predict adverse outcomes within the following year significantly increased. Conclusions. Specific circulating proteins are associated with hemodynamic variables in pediatric PH. If confirmed in additional cohorts, measurement of these proteins could aid patient care and design of clinical trials by identifying patients at risk for adverse events. These findings also further support a role for inflammation in pediatric PH.http://dx.doi.org/10.1155/2012/143428 |
| spellingShingle | Mark Duncan Brandie D. Wagner Keri Murray Jenna Allen Kelley Colvin Frank J. Accurso D. Dunbar Ivy Circulating Cytokines and Growth Factors in Pediatric Pulmonary Hypertension Mediators of Inflammation |
| title | Circulating Cytokines and Growth Factors in Pediatric Pulmonary Hypertension |
| title_full | Circulating Cytokines and Growth Factors in Pediatric Pulmonary Hypertension |
| title_fullStr | Circulating Cytokines and Growth Factors in Pediatric Pulmonary Hypertension |
| title_full_unstemmed | Circulating Cytokines and Growth Factors in Pediatric Pulmonary Hypertension |
| title_short | Circulating Cytokines and Growth Factors in Pediatric Pulmonary Hypertension |
| title_sort | circulating cytokines and growth factors in pediatric pulmonary hypertension |
| url | http://dx.doi.org/10.1155/2012/143428 |
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