Chimeric SF-25 monoclonal antibody as a targeted therapy for SLC3A2 in adult T-cell leukemia/lymphoma

Chimeric SF-25 monoclonal antibody as a targeted therapy for SLC3A2 in adult T-cell leukemia/lymphoma

Abstract The SF-25 antigen (SF-25 Ag), which functions as the amino acid transporter solute carrier family 3 member 2 (SLC3A2), is essential for regulatory T (Treg) cell maintenance and is highly expressed in adult T-cell leukemia/lymphoma (ATL) cells. We analyzed SF-25 Ag expression in CD4+peripher...

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Bibliographic Details
Main Authors: Shinsuke Suzuki, Xiao-Yan Lin, Shuichi Hanada, Kimiharu Uozumi, Maki Otsuka, Satsuki Owatari, Koichi Haraguchi, Makoto Yoshimitsu, Kenji Ishitsuka, Hiroshi Takahashi
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
SF-25 Ag
SLC3A2
HTLV-1
Adult T-cell leukemia/lymphoma
Magnetic cell sorting
c-SF-25 Mab
Online Access:https://doi.org/10.1038/s41598-025-14572-1
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