Practical Aspects of Allogeneic Hematopoietic Cell Transplantation for Patients with Poor-Risk Chronic Lymphocytic Leukemia
Allogeneic hematopoietic cell transplantation has become a viable option for younger patients with poor-risk chronic lymphocytic leukemia. The results obtained with either conventional or reduced-intensity conditioning regimens have been recently evaluated and compared with alternative nontransplant...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2011-01-01
|
| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2011.21 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849410551177805824 |
|---|---|
| author | Julio Delgado Rafael F. Duarte |
| author_facet | Julio Delgado Rafael F. Duarte |
| author_sort | Julio Delgado |
| collection | DOAJ |
| description | Allogeneic hematopoietic cell transplantation has become a viable option for younger patients with poor-risk chronic lymphocytic leukemia. The results obtained with either conventional or reduced-intensity conditioning regimens have been recently evaluated and compared with alternative nontransplant strategies. This manuscript deals with practical aspects of the procedure, including patient and donor selection, conditioning regimen, GVHD prophylaxis, disease monitoring, infectious and noninfectious complications, and timing of the procedure. Finally, we speculate on how we could improve the results obtained with the procedure and new advances currently in clinical trials. |
| format | Article |
| id | doaj-art-7b1f3bbfc8b64a40b12daac5f9035da4 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-7b1f3bbfc8b64a40b12daac5f9035da42025-08-20T03:35:03ZengWileyThe Scientific World Journal1537-744X2011-01-011116117210.1100/tsw.2011.21Practical Aspects of Allogeneic Hematopoietic Cell Transplantation for Patients with Poor-Risk Chronic Lymphocytic LeukemiaJulio Delgado0Rafael F. Duarte1Department of Hematology, Hospital de la Santa Creu i Sant Pau, Barcelona, SpainDepartment of Hematology, ICO-Hospital Duran i Reynals, Barcelona, SpainAllogeneic hematopoietic cell transplantation has become a viable option for younger patients with poor-risk chronic lymphocytic leukemia. The results obtained with either conventional or reduced-intensity conditioning regimens have been recently evaluated and compared with alternative nontransplant strategies. This manuscript deals with practical aspects of the procedure, including patient and donor selection, conditioning regimen, GVHD prophylaxis, disease monitoring, infectious and noninfectious complications, and timing of the procedure. Finally, we speculate on how we could improve the results obtained with the procedure and new advances currently in clinical trials.http://dx.doi.org/10.1100/tsw.2011.21 |
| spellingShingle | Julio Delgado Rafael F. Duarte Practical Aspects of Allogeneic Hematopoietic Cell Transplantation for Patients with Poor-Risk Chronic Lymphocytic Leukemia The Scientific World Journal |
| title | Practical Aspects of Allogeneic Hematopoietic Cell Transplantation for Patients with Poor-Risk Chronic Lymphocytic Leukemia |
| title_full | Practical Aspects of Allogeneic Hematopoietic Cell Transplantation for Patients with Poor-Risk Chronic Lymphocytic Leukemia |
| title_fullStr | Practical Aspects of Allogeneic Hematopoietic Cell Transplantation for Patients with Poor-Risk Chronic Lymphocytic Leukemia |
| title_full_unstemmed | Practical Aspects of Allogeneic Hematopoietic Cell Transplantation for Patients with Poor-Risk Chronic Lymphocytic Leukemia |
| title_short | Practical Aspects of Allogeneic Hematopoietic Cell Transplantation for Patients with Poor-Risk Chronic Lymphocytic Leukemia |
| title_sort | practical aspects of allogeneic hematopoietic cell transplantation for patients with poor risk chronic lymphocytic leukemia |
| url | http://dx.doi.org/10.1100/tsw.2011.21 |
| work_keys_str_mv | AT juliodelgado practicalaspectsofallogeneichematopoieticcelltransplantationforpatientswithpoorriskchroniclymphocyticleukemia AT rafaelfduarte practicalaspectsofallogeneichematopoieticcelltransplantationforpatientswithpoorriskchroniclymphocyticleukemia |