Synthesis of Polymer Assembled Mesoporous CaCO3 Nanoparticles for Molecular Targeting and pH-Responsive Controlled Drug Release
CaCO3 nanoparticles are very suitable as intelligent carriers because of their ideal biocompatibility and biodegradability, especially their sensitivity to pH. In this paper, we use mesoporous CaCO3 nanoparticles as intelligent carrier, sodium alginate, and chitosan as alternating assembly materials...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-01-01
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| Series: | Advances in Polymer Technology |
| Online Access: | http://dx.doi.org/10.1155/2020/8749238 |
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| _version_ | 1832555114820272128 |
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| author | Jinjing Xing Yeqiang Cai Yikun Wang Haifu Zheng Yujia Liu |
| author_facet | Jinjing Xing Yeqiang Cai Yikun Wang Haifu Zheng Yujia Liu |
| author_sort | Jinjing Xing |
| collection | DOAJ |
| description | CaCO3 nanoparticles are very suitable as intelligent carriers because of their ideal biocompatibility and biodegradability, especially their sensitivity to pH. In this paper, we use mesoporous CaCO3 nanoparticles as intelligent carrier, sodium alginate, and chitosan as alternating assembly materials, folic acid as target molecules, and exploit layer-by-layer assembly technology to achieve sensitive molecular targeting and pH response drug release. Mesoporous CaCO3 hybrid nanoparticles have high drug loading on doxorubicin. The effects of different pH values on drug release in vitro were studied by regulating simulated body fluids with different pH values. The cytotoxicity, targeting effect, and drug release of human cervical cancer cell line (HeLa) were studied by cell vitality and imaging experiments. All the evidence suggests that the smart mesoporous CaCO3 nanoparticles may be a potential clinical application platform for cancer therapy. |
| format | Article |
| id | doaj-art-7b0befaab7ee45d7ae0cb4956a4e1b4b |
| institution | Kabale University |
| issn | 0730-6679 1098-2329 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Polymer Technology |
| spelling | doaj-art-7b0befaab7ee45d7ae0cb4956a4e1b4b2025-02-03T05:49:32ZengWileyAdvances in Polymer Technology0730-66791098-23292020-01-01202010.1155/2020/87492388749238Synthesis of Polymer Assembled Mesoporous CaCO3 Nanoparticles for Molecular Targeting and pH-Responsive Controlled Drug ReleaseJinjing Xing0Yeqiang Cai1Yikun Wang2Haifu Zheng3Yujia Liu4Jiangsu Institute of Metrology, Nanjing, Jiangsu 210023, ChinaJiangsu Institute of Metrology, Nanjing, Jiangsu 210023, ChinaJiangsu Institute of Metrology, Nanjing, Jiangsu 210023, ChinaJiangsu Institute of Metrology, Nanjing, Jiangsu 210023, ChinaJiangsu Institute of Metrology, Nanjing, Jiangsu 210023, ChinaCaCO3 nanoparticles are very suitable as intelligent carriers because of their ideal biocompatibility and biodegradability, especially their sensitivity to pH. In this paper, we use mesoporous CaCO3 nanoparticles as intelligent carrier, sodium alginate, and chitosan as alternating assembly materials, folic acid as target molecules, and exploit layer-by-layer assembly technology to achieve sensitive molecular targeting and pH response drug release. Mesoporous CaCO3 hybrid nanoparticles have high drug loading on doxorubicin. The effects of different pH values on drug release in vitro were studied by regulating simulated body fluids with different pH values. The cytotoxicity, targeting effect, and drug release of human cervical cancer cell line (HeLa) were studied by cell vitality and imaging experiments. All the evidence suggests that the smart mesoporous CaCO3 nanoparticles may be a potential clinical application platform for cancer therapy.http://dx.doi.org/10.1155/2020/8749238 |
| spellingShingle | Jinjing Xing Yeqiang Cai Yikun Wang Haifu Zheng Yujia Liu Synthesis of Polymer Assembled Mesoporous CaCO3 Nanoparticles for Molecular Targeting and pH-Responsive Controlled Drug Release Advances in Polymer Technology |
| title | Synthesis of Polymer Assembled Mesoporous CaCO3 Nanoparticles for Molecular Targeting and pH-Responsive Controlled Drug Release |
| title_full | Synthesis of Polymer Assembled Mesoporous CaCO3 Nanoparticles for Molecular Targeting and pH-Responsive Controlled Drug Release |
| title_fullStr | Synthesis of Polymer Assembled Mesoporous CaCO3 Nanoparticles for Molecular Targeting and pH-Responsive Controlled Drug Release |
| title_full_unstemmed | Synthesis of Polymer Assembled Mesoporous CaCO3 Nanoparticles for Molecular Targeting and pH-Responsive Controlled Drug Release |
| title_short | Synthesis of Polymer Assembled Mesoporous CaCO3 Nanoparticles for Molecular Targeting and pH-Responsive Controlled Drug Release |
| title_sort | synthesis of polymer assembled mesoporous caco3 nanoparticles for molecular targeting and ph responsive controlled drug release |
| url | http://dx.doi.org/10.1155/2020/8749238 |
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