Large-scale single-nuclei profiling identifies role for ATRNL1 in atrial fibrillation

Large-scale single-nuclei profiling identifies role for ATRNL1 in atrial fibrillation

Abstract Atrial fibrillation (AF) is the most common sustained arrhythmia in humans, yet the molecular basis of AF remains incompletely understood. To determine the cell type-specific transcriptional changes underlying AF, we perform single-nucleus RNA-seq (snRNA-seq) on left atrial (LA) samples fro...

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Bibliographic Details
Main Authors: Matthew C. Hill, Bridget Simonson, Carolina Roselli, Ling Xiao, Caroline N. Herndon, Mark Chaffin, Helene Mantineo, Ondine Atwa, Harshit Bhasin, Yasmine Guedira, Kenneth C. Bedi, Kenneth B. Margulies, Carla A. Klattenhoff, Nathan R. Tucker, Patrick T. Ellinor
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-54296-w
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