Development of a highly sensitive luciferase assay for intracellular evaluation of coronavirus Mpro activity

Development of a highly sensitive luciferase assay for intracellular evaluation of coronavirus Mpro activity

COVID-19, caused by SARS-CoV-2 virus, has emerged as a global threat to human health. The main protease (Mpro) of SARS-CoV-2 is an excellent target for the development of antiviral drugs against COVID-19, and various protease biosensors have been developed to evaluate anti-coronavirus drugs. However...

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Bibliographic Details
Main Authors: Bao Dong, Yuehong Chen, Xin Wang, Jing Li, Sen Zhang, Xiaoping Kang, Yuchang Li, Biao Li, Liangning Liao, Zhengwei Zhang, Jiaqi Xiong, Lele Shao, Shenghai Huang, Ye Feng, Tao Jiang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Microbiology
Subjects:
coronavirus
main protease
protease activity
reporter system
NanoBit
protease inhibitor
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2025.1560251/full
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