Alanine with the Precipitate of Tomato Juice Administered to Rats Enhances the Reduction in Blood Ethanol Levels
Delay in gastric emptying (GE) lowers the blood ethanol concentration (BEC) after alcohol administration. We previously demonstrated that water-insoluble fractions, mainly comprising dietary fiber derived from many types of botanical foods, possessed the ability to absorb ethanol-containing aqueous...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Nutrition and Metabolism |
| Online Access: | http://dx.doi.org/10.1155/2015/280781 |
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| author | Shunji Oshima Sachie Shiiya Yoshimi Tokumaru Tomomasa Kanda |
| author_facet | Shunji Oshima Sachie Shiiya Yoshimi Tokumaru Tomomasa Kanda |
| author_sort | Shunji Oshima |
| collection | DOAJ |
| description | Delay in gastric emptying (GE) lowers the blood ethanol concentration (BEC) after alcohol administration. We previously demonstrated that water-insoluble fractions, mainly comprising dietary fiber derived from many types of botanical foods, possessed the ability to absorb ethanol-containing aqueous solutions. Furthermore, there was a significant correlation between the absorption of ethanol and lowering of BEC because of delay in GE. Here we identified dietary nutrients that synergize with the water-insoluble fraction of tomatoes to lower BEC in rats. Consequently, unlike tomato juice without alanine, tomato juice with 5.0% alanine decreased BEC depending on the delay in GE and mediated the ethanol-induced decrease in the spontaneous motor activity (an indicator of drunkenness). Our findings indicate that the synergism between tomato juice and alanine to reduce the absorption of ethanol was attributable to the effect of alanine on precipitates such as the water-insoluble fraction of tomatoes. |
| format | Article |
| id | doaj-art-7b008aca31ea4f89add3c63ce2638fd4 |
| institution | Kabale University |
| issn | 2090-0724 2090-0732 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Nutrition and Metabolism |
| spelling | doaj-art-7b008aca31ea4f89add3c63ce2638fd42025-02-03T01:28:42ZengWileyJournal of Nutrition and Metabolism2090-07242090-07322015-01-01201510.1155/2015/280781280781Alanine with the Precipitate of Tomato Juice Administered to Rats Enhances the Reduction in Blood Ethanol LevelsShunji Oshima0Sachie Shiiya1Yoshimi Tokumaru2Tomomasa Kanda3Research & Development Laboratories for Innovation, Asahi Group Holdings, Ltd., Ibaraki 302-0106, JapanResearch & Development Laboratories for Innovation, Asahi Group Holdings, Ltd., Ibaraki 302-0106, JapanResearch & Development Laboratories for Innovation, Asahi Group Holdings, Ltd., Ibaraki 302-0106, JapanResearch & Development Laboratories for Innovation, Asahi Group Holdings, Ltd., Ibaraki 302-0106, JapanDelay in gastric emptying (GE) lowers the blood ethanol concentration (BEC) after alcohol administration. We previously demonstrated that water-insoluble fractions, mainly comprising dietary fiber derived from many types of botanical foods, possessed the ability to absorb ethanol-containing aqueous solutions. Furthermore, there was a significant correlation between the absorption of ethanol and lowering of BEC because of delay in GE. Here we identified dietary nutrients that synergize with the water-insoluble fraction of tomatoes to lower BEC in rats. Consequently, unlike tomato juice without alanine, tomato juice with 5.0% alanine decreased BEC depending on the delay in GE and mediated the ethanol-induced decrease in the spontaneous motor activity (an indicator of drunkenness). Our findings indicate that the synergism between tomato juice and alanine to reduce the absorption of ethanol was attributable to the effect of alanine on precipitates such as the water-insoluble fraction of tomatoes.http://dx.doi.org/10.1155/2015/280781 |
| spellingShingle | Shunji Oshima Sachie Shiiya Yoshimi Tokumaru Tomomasa Kanda Alanine with the Precipitate of Tomato Juice Administered to Rats Enhances the Reduction in Blood Ethanol Levels Journal of Nutrition and Metabolism |
| title | Alanine with the Precipitate of Tomato Juice Administered to Rats Enhances the Reduction in Blood Ethanol Levels |
| title_full | Alanine with the Precipitate of Tomato Juice Administered to Rats Enhances the Reduction in Blood Ethanol Levels |
| title_fullStr | Alanine with the Precipitate of Tomato Juice Administered to Rats Enhances the Reduction in Blood Ethanol Levels |
| title_full_unstemmed | Alanine with the Precipitate of Tomato Juice Administered to Rats Enhances the Reduction in Blood Ethanol Levels |
| title_short | Alanine with the Precipitate of Tomato Juice Administered to Rats Enhances the Reduction in Blood Ethanol Levels |
| title_sort | alanine with the precipitate of tomato juice administered to rats enhances the reduction in blood ethanol levels |
| url | http://dx.doi.org/10.1155/2015/280781 |
| work_keys_str_mv | AT shunjioshima alaninewiththeprecipitateoftomatojuiceadministeredtoratsenhancesthereductioninbloodethanollevels AT sachieshiiya alaninewiththeprecipitateoftomatojuiceadministeredtoratsenhancesthereductioninbloodethanollevels AT yoshimitokumaru alaninewiththeprecipitateoftomatojuiceadministeredtoratsenhancesthereductioninbloodethanollevels AT tomomasakanda alaninewiththeprecipitateoftomatojuiceadministeredtoratsenhancesthereductioninbloodethanollevels |