Hyaluronic acid efficacy in root coverage procedures: a systematic review and meta-analysis
Abstract Background Treatment of gingival recessions through surgical approaches is a common periodontal intervention. There is a rise in using biologics in root coverage procedures. As it has been shown that hyaluronic acid (HA) promotes wound healing, this review aimed to assess its efficacy in th...
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| Format: | Article |
| Language: | English |
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BMC
2025-01-01
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| Series: | BMC Oral Health |
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| Online Access: | https://doi.org/10.1186/s12903-025-05526-0 |
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| author | Mohammadreza Talebi Ardakani Anahita Moscowchi Amir Talebi Mohammad Hossein Talebi |
| author_facet | Mohammadreza Talebi Ardakani Anahita Moscowchi Amir Talebi Mohammad Hossein Talebi |
| author_sort | Mohammadreza Talebi Ardakani |
| collection | DOAJ |
| description | Abstract Background Treatment of gingival recessions through surgical approaches is a common periodontal intervention. There is a rise in using biologics in root coverage procedures. As it has been shown that hyaluronic acid (HA) promotes wound healing, this review aimed to assess its efficacy in the treatment of gingival recessions. Methods An electronic search was conducted across several databases (Medline/ PubMed, Embase, Scopus, Web of Science) supplemented by manual searching. The effectiveness of using HA was evaluated using various outcome measures, with the primary indicators being complete and mean coverage, recession depth, and recession width. Meta-analysis was performed to estimate the differences between test and control sites. Results A total of 9 studies were eligible for inclusion. The overall analysis showed no significant difference between coronally advanced flap (CAF) + HA and control groups (CAF alone or CAF + sub-epithelial connective tissue graft) in terms of mean root coverage with a mean difference of 8.23 (95% confidence interval -3.06 to 19.53) and p = 0.12. Conclusions The current evidence suggests that the local application of HA may have some slight benefits over CAF alone in certain parameters. Nevertheless, its application does not add significant benefits to connective tissue graft. Given the high heterogeneity among the studies, further research with extended follow-up periods is necessary to better understand the clinical implications of using hyaluronic acid in this context. Trial registration CRD42024580649 |
| format | Article |
| id | doaj-art-7afb5abdb9b14b8b9c3bfe7152411313 |
| institution | Kabale University |
| issn | 1472-6831 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Oral Health |
| spelling | doaj-art-7afb5abdb9b14b8b9c3bfe71524113132025-01-26T12:55:13ZengBMCBMC Oral Health1472-68312025-01-0125111010.1186/s12903-025-05526-0Hyaluronic acid efficacy in root coverage procedures: a systematic review and meta-analysisMohammadreza Talebi Ardakani0Anahita Moscowchi1Amir Talebi2Mohammad Hossein Talebi3Dental Research Center, Research Institute for Dental Sciences, Shahid Beheshti University of Medical SciencesDental Research Center, Research Institute for Dental Sciences, Shahid Beheshti University of Medical SciencesDental School, Universidad Europea de MadridQueen’s University BelfastAbstract Background Treatment of gingival recessions through surgical approaches is a common periodontal intervention. There is a rise in using biologics in root coverage procedures. As it has been shown that hyaluronic acid (HA) promotes wound healing, this review aimed to assess its efficacy in the treatment of gingival recessions. Methods An electronic search was conducted across several databases (Medline/ PubMed, Embase, Scopus, Web of Science) supplemented by manual searching. The effectiveness of using HA was evaluated using various outcome measures, with the primary indicators being complete and mean coverage, recession depth, and recession width. Meta-analysis was performed to estimate the differences between test and control sites. Results A total of 9 studies were eligible for inclusion. The overall analysis showed no significant difference between coronally advanced flap (CAF) + HA and control groups (CAF alone or CAF + sub-epithelial connective tissue graft) in terms of mean root coverage with a mean difference of 8.23 (95% confidence interval -3.06 to 19.53) and p = 0.12. Conclusions The current evidence suggests that the local application of HA may have some slight benefits over CAF alone in certain parameters. Nevertheless, its application does not add significant benefits to connective tissue graft. Given the high heterogeneity among the studies, further research with extended follow-up periods is necessary to better understand the clinical implications of using hyaluronic acid in this context. Trial registration CRD42024580649https://doi.org/10.1186/s12903-025-05526-0Gingival recessionRoot coverageHyaluronic acid |
| spellingShingle | Mohammadreza Talebi Ardakani Anahita Moscowchi Amir Talebi Mohammad Hossein Talebi Hyaluronic acid efficacy in root coverage procedures: a systematic review and meta-analysis BMC Oral Health Gingival recession Root coverage Hyaluronic acid |
| title | Hyaluronic acid efficacy in root coverage procedures: a systematic review and meta-analysis |
| title_full | Hyaluronic acid efficacy in root coverage procedures: a systematic review and meta-analysis |
| title_fullStr | Hyaluronic acid efficacy in root coverage procedures: a systematic review and meta-analysis |
| title_full_unstemmed | Hyaluronic acid efficacy in root coverage procedures: a systematic review and meta-analysis |
| title_short | Hyaluronic acid efficacy in root coverage procedures: a systematic review and meta-analysis |
| title_sort | hyaluronic acid efficacy in root coverage procedures a systematic review and meta analysis |
| topic | Gingival recession Root coverage Hyaluronic acid |
| url | https://doi.org/10.1186/s12903-025-05526-0 |
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