Peritoneal Adipocytes and Their Role in Inflammation during Peritoneal Dialysis
Adipose tissue is a major site of chronic inflammation associated with peritoneal dialysis (PD) frequently complicating peritonitis. Adiposity-associated inflammation plays a significant contributory role in the development of chronic inflammation in patients undergoing maintenance PD. However, the...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2010/495416 |
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| _version_ | 1832566829100302336 |
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| author | Kar Neng Lai Joseph C. K. Leung |
| author_facet | Kar Neng Lai Joseph C. K. Leung |
| author_sort | Kar Neng Lai |
| collection | DOAJ |
| description | Adipose tissue is a major site of chronic inflammation associated with peritoneal dialysis (PD) frequently complicating peritonitis. Adiposity-associated inflammation plays a significant contributory role in the development of chronic inflammation in patients undergoing maintenance PD. However, the molecular and cellular mechanisms of this link remain uncertain. Adipose tissue synthesizes different adipokines and cytokines that orchestrate and regulate inflammation, insulin action, and glucose metabolism locally and systemically. In return, inflammation retards adipocyte differentiation and further exacerbates adipose dysfunction and inflammation. An understanding of the inflammatory roles played by adipose tissue during PD and the healing mechanism of injured mesothelium will help to devise new therapeutic approach to slow the progression of peritoneal damage during peritoneal dialysis. This article reviews the roles of peritoneal adipose tissue in chronic peritoneal inflammation under PD and in serosal repair during PD. |
| format | Article |
| id | doaj-art-7af2039a079b45deaf52fe48267b1fcf |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-7af2039a079b45deaf52fe48267b1fcf2025-02-03T01:03:09ZengWileyMediators of Inflammation0962-93511466-18612010-01-01201010.1155/2010/495416495416Peritoneal Adipocytes and Their Role in Inflammation during Peritoneal DialysisKar Neng Lai0Joseph C. K. Leung1Department of Medicine, Queen Mary Hospital, University of Hong Kong, 102 Pokfulam Road, Hong KongDepartment of Medicine, Queen Mary Hospital, University of Hong Kong, 102 Pokfulam Road, Hong KongAdipose tissue is a major site of chronic inflammation associated with peritoneal dialysis (PD) frequently complicating peritonitis. Adiposity-associated inflammation plays a significant contributory role in the development of chronic inflammation in patients undergoing maintenance PD. However, the molecular and cellular mechanisms of this link remain uncertain. Adipose tissue synthesizes different adipokines and cytokines that orchestrate and regulate inflammation, insulin action, and glucose metabolism locally and systemically. In return, inflammation retards adipocyte differentiation and further exacerbates adipose dysfunction and inflammation. An understanding of the inflammatory roles played by adipose tissue during PD and the healing mechanism of injured mesothelium will help to devise new therapeutic approach to slow the progression of peritoneal damage during peritoneal dialysis. This article reviews the roles of peritoneal adipose tissue in chronic peritoneal inflammation under PD and in serosal repair during PD.http://dx.doi.org/10.1155/2010/495416 |
| spellingShingle | Kar Neng Lai Joseph C. K. Leung Peritoneal Adipocytes and Their Role in Inflammation during Peritoneal Dialysis Mediators of Inflammation |
| title | Peritoneal Adipocytes and Their Role in Inflammation during Peritoneal Dialysis |
| title_full | Peritoneal Adipocytes and Their Role in Inflammation during Peritoneal Dialysis |
| title_fullStr | Peritoneal Adipocytes and Their Role in Inflammation during Peritoneal Dialysis |
| title_full_unstemmed | Peritoneal Adipocytes and Their Role in Inflammation during Peritoneal Dialysis |
| title_short | Peritoneal Adipocytes and Their Role in Inflammation during Peritoneal Dialysis |
| title_sort | peritoneal adipocytes and their role in inflammation during peritoneal dialysis |
| url | http://dx.doi.org/10.1155/2010/495416 |
| work_keys_str_mv | AT karnenglai peritonealadipocytesandtheirroleininflammationduringperitonealdialysis AT josephckleung peritonealadipocytesandtheirroleininflammationduringperitonealdialysis |