A Meta-Analysis of GBA-Related Clinical Symptoms in Parkinson’s Disease
Background. GBA gene had been proved to be a crucial gene to the risk of PD. Numerous studies had discussed about the unique clinical characteristics of PD patients with GBA carriers (GBA + PD). However, there was lack of updated comprehensive analysis on the topic. In order to clarify the associati...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Parkinson's Disease |
| Online Access: | http://dx.doi.org/10.1155/2018/3136415 |
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| _version_ | 1832552300430753792 |
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| author | Yuan Zhang Li Shu Xun Zhou Hongxu Pan Qian Xu Jifeng Guo Beisha Tang Qiying Sun |
| author_facet | Yuan Zhang Li Shu Xun Zhou Hongxu Pan Qian Xu Jifeng Guo Beisha Tang Qiying Sun |
| author_sort | Yuan Zhang |
| collection | DOAJ |
| description | Background. GBA gene had been proved to be a crucial gene to the risk of PD. Numerous studies had discussed about the unique clinical characteristics of PD patients with GBA carriers (GBA + PD). However, there was lack of updated comprehensive analysis on the topic. In order to clarify the association between GBA variants and the clinical phenotypes of PD, we conducted this comprehensive meta-analysis. Method. Medline, Embase, and Cochrane were used to perform the searching. Strict selection criteria were followed in screening for new published articles or data. Revman 5.3 software was applied to perform the total statistical analysis, and funnel plots in the software were used to assess the publication biases. Results. A total of 26 articles including 931 GBA + PD and 14861 GBA noncarriers of PD (GBA − PD) were involved in the final meta-analysis, and 14 of them were either newly added publications or related data newly analyzed compared with the version published in 2015. Then, a series of symptoms containing depression, orthostatic hypotension, motor fluctuation, wearing-off, and freezing were newly analyzed due to more articles eligible. Besides, clinical features like family history, AAO, UPDRS-III, H-Y, and dementia previously analyzed were updated with new data added. Significant statistical differences were found in wearing-off, family history, AAO, UPDRS-III, and dementia (OR: 1.14, 1.65; MD: −3.61, 2.17; OR: 2.44; p: 0.03, <0.00001, <0.00001, 0.003, and <0.00001). Depression was slightly associated with GBA + PD (OR: 1.47; p: 0.04). Clinical symptoms such as H-Y, orthostatic hypotension, motor fluctuation, and freezing did not feature GBA + PD. Conclusion. Our results demonstrated that there were unique clinical features in GBA + PD which can help the management of the whole duration of PD patients. |
| format | Article |
| id | doaj-art-7af1810ee7f340f78bc0a6d62588e369 |
| institution | Kabale University |
| issn | 2090-8083 2042-0080 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Parkinson's Disease |
| spelling | doaj-art-7af1810ee7f340f78bc0a6d62588e3692025-02-03T05:59:05ZengWileyParkinson's Disease2090-80832042-00802018-01-01201810.1155/2018/31364153136415A Meta-Analysis of GBA-Related Clinical Symptoms in Parkinson’s DiseaseYuan Zhang0Li Shu1Xun Zhou2Hongxu Pan3Qian Xu4Jifeng Guo5Beisha Tang6Qiying Sun7Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, ChinaNational Clinical Research Center for Geriatric Disorders, Changsha, Hunan 410078, ChinaBackground. GBA gene had been proved to be a crucial gene to the risk of PD. Numerous studies had discussed about the unique clinical characteristics of PD patients with GBA carriers (GBA + PD). However, there was lack of updated comprehensive analysis on the topic. In order to clarify the association between GBA variants and the clinical phenotypes of PD, we conducted this comprehensive meta-analysis. Method. Medline, Embase, and Cochrane were used to perform the searching. Strict selection criteria were followed in screening for new published articles or data. Revman 5.3 software was applied to perform the total statistical analysis, and funnel plots in the software were used to assess the publication biases. Results. A total of 26 articles including 931 GBA + PD and 14861 GBA noncarriers of PD (GBA − PD) were involved in the final meta-analysis, and 14 of them were either newly added publications or related data newly analyzed compared with the version published in 2015. Then, a series of symptoms containing depression, orthostatic hypotension, motor fluctuation, wearing-off, and freezing were newly analyzed due to more articles eligible. Besides, clinical features like family history, AAO, UPDRS-III, H-Y, and dementia previously analyzed were updated with new data added. Significant statistical differences were found in wearing-off, family history, AAO, UPDRS-III, and dementia (OR: 1.14, 1.65; MD: −3.61, 2.17; OR: 2.44; p: 0.03, <0.00001, <0.00001, 0.003, and <0.00001). Depression was slightly associated with GBA + PD (OR: 1.47; p: 0.04). Clinical symptoms such as H-Y, orthostatic hypotension, motor fluctuation, and freezing did not feature GBA + PD. Conclusion. Our results demonstrated that there were unique clinical features in GBA + PD which can help the management of the whole duration of PD patients.http://dx.doi.org/10.1155/2018/3136415 |
| spellingShingle | Yuan Zhang Li Shu Xun Zhou Hongxu Pan Qian Xu Jifeng Guo Beisha Tang Qiying Sun A Meta-Analysis of GBA-Related Clinical Symptoms in Parkinson’s Disease Parkinson's Disease |
| title | A Meta-Analysis of GBA-Related Clinical Symptoms in Parkinson’s Disease |
| title_full | A Meta-Analysis of GBA-Related Clinical Symptoms in Parkinson’s Disease |
| title_fullStr | A Meta-Analysis of GBA-Related Clinical Symptoms in Parkinson’s Disease |
| title_full_unstemmed | A Meta-Analysis of GBA-Related Clinical Symptoms in Parkinson’s Disease |
| title_short | A Meta-Analysis of GBA-Related Clinical Symptoms in Parkinson’s Disease |
| title_sort | meta analysis of gba related clinical symptoms in parkinson s disease |
| url | http://dx.doi.org/10.1155/2018/3136415 |
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