Modeling neuroinflammatory interactions between microglia and astrocytes in a human iPSC-based coculture platform

Modeling neuroinflammatory interactions between microglia and astrocytes in a human iPSC-based coculture platform

Abstract Background Microglia and astrocytes are central mediators of neuroinflammation in several neurodegenerative diseases. Their intricate crosstalk and contributions to pathogenesis remain elusive, highlighting the need for innovative in vitro approaches for investigating glial interactions in...

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Main Authors: Iisa Tujula, Tanja Hyvärinen, Johanna Lotila, Julia Rogal, Dimitrios Voulgaris, Lassi Sukki, Kaisa Tornberg, Katri Korpela, Henna Jäntti, Tarja Malm, Anna Herland, Pasi Kallio, Susanna Narkilahti, Sanna Hagman
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Cell Communication and Signaling
Subjects:
Astrocytes
Disease modeling
Glial crosstalk
iPSC
Microglia
Microphysiological system
Online Access:https://doi.org/10.1186/s12964-025-02304-x
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