Comparison of the Effects of Electrolytic and Chemical Destruction of the Red Nucleus on the Compensatory Capacity of Rats With Rubrospinal Tract Lesions
Transection of the rubrospinal tract in rats, performed before lesion of the red nucleus, resulted in the facilitated recovery of motor activity and operantly conditioned reflexes. Such facilitation was absent when the red nucleus is lesioned alone. This phenomenon is explained by the switching of d...
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| Format: | Article |
| Language: | English |
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Wiley
1999-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/NP.1999.123 |
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| author | V. V. Fanardjian E. V. Papoyan V. I. Pogossian O. V. Gevorkyan |
| author_facet | V. V. Fanardjian E. V. Papoyan V. I. Pogossian O. V. Gevorkyan |
| author_sort | V. V. Fanardjian |
| collection | DOAJ |
| description | Transection of the rubrospinal tract in rats, performed before lesion of the red nucleus, resulted in the facilitated recovery of motor
activity and operantly conditioned reflexes. Such facilitation was absent when the red nucleus is lesioned alone. This phenomenon is
explained by the switching of descending influences on the corticospinal tract through the participation of the following system: red nucleus—inferior olive—cerebellum—ventrolateral thalamic nucleus—cerebral cortex. The above mentioned facilitating influence on the recovery process was particularly prominent in rats with quinolinic acid-induced lesion of the red nucleus. Under these conditions, the cerebellar ascending fibers to the ventrolateral thalamic nucleus were preserved. Decreased facilitated recovery following electrolytic lesion of the red nucleus suggests the existence of additional cerebello-cortical pathways for the realization of the switching phenomenon. |
| format | Article |
| id | doaj-art-7ae772a0fa24453082cbb00985356ea0 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 1999-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-7ae772a0fa24453082cbb00985356ea02025-02-03T01:28:36ZengWileyNeural Plasticity2090-59041687-54431999-01-016412313110.1155/NP.1999.123Comparison of the Effects of Electrolytic and Chemical Destruction of the Red Nucleus on the Compensatory Capacity of Rats With Rubrospinal Tract LesionsV. V. Fanardjian0E. V. Papoyan1V. I. Pogossian2O. V. Gevorkyan3L.A. Orblei Institute of Physiology, National Academy of Sciences of Armenia, 22 Orblei Bros. Str., Yerevan 375028, ArmeniaL.A. Orblei Institute of Physiology, National Academy of Sciences of Armenia, 22 Orblei Bros. Str., Yerevan 375028, ArmeniaL.A. Orblei Institute of Physiology, National Academy of Sciences of Armenia, 22 Orblei Bros. Str., Yerevan 375028, ArmeniaL.A. Orblei Institute of Physiology, National Academy of Sciences of Armenia, 22 Orblei Bros. Str., Yerevan 375028, ArmeniaTransection of the rubrospinal tract in rats, performed before lesion of the red nucleus, resulted in the facilitated recovery of motor activity and operantly conditioned reflexes. Such facilitation was absent when the red nucleus is lesioned alone. This phenomenon is explained by the switching of descending influences on the corticospinal tract through the participation of the following system: red nucleus—inferior olive—cerebellum—ventrolateral thalamic nucleus—cerebral cortex. The above mentioned facilitating influence on the recovery process was particularly prominent in rats with quinolinic acid-induced lesion of the red nucleus. Under these conditions, the cerebellar ascending fibers to the ventrolateral thalamic nucleus were preserved. Decreased facilitated recovery following electrolytic lesion of the red nucleus suggests the existence of additional cerebello-cortical pathways for the realization of the switching phenomenon.http://dx.doi.org/10.1155/NP.1999.123 |
| spellingShingle | V. V. Fanardjian E. V. Papoyan V. I. Pogossian O. V. Gevorkyan Comparison of the Effects of Electrolytic and Chemical Destruction of the Red Nucleus on the Compensatory Capacity of Rats With Rubrospinal Tract Lesions Neural Plasticity |
| title | Comparison of the Effects of Electrolytic and Chemical Destruction of the Red Nucleus on the Compensatory Capacity of Rats With Rubrospinal Tract Lesions |
| title_full | Comparison of the Effects of Electrolytic and Chemical Destruction of the Red Nucleus on the Compensatory Capacity of Rats With Rubrospinal Tract Lesions |
| title_fullStr | Comparison of the Effects of Electrolytic and Chemical Destruction of the Red Nucleus on the Compensatory Capacity of Rats With Rubrospinal Tract Lesions |
| title_full_unstemmed | Comparison of the Effects of Electrolytic and Chemical Destruction of the Red Nucleus on the Compensatory Capacity of Rats With Rubrospinal Tract Lesions |
| title_short | Comparison of the Effects of Electrolytic and Chemical Destruction of the Red Nucleus on the Compensatory Capacity of Rats With Rubrospinal Tract Lesions |
| title_sort | comparison of the effects of electrolytic and chemical destruction of the red nucleus on the compensatory capacity of rats with rubrospinal tract lesions |
| url | http://dx.doi.org/10.1155/NP.1999.123 |
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