Lung Cancer: A Classic Example of Tumor Escape and Progression While Providing Opportunities for Immunological Intervention
Lung cancers remain one of the most common and deadly cancers in the world today (12.5% of newly diagnosed cancers) despite current advances in chemo- and radiation therapies. Often, by the time these tumors are diagnosed, they have already metastasized. These tumors demonstrate the classic hallmark...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2012/160724 |
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| _version_ | 1832548468073168896 |
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| author | Martin R. Jadus Josephine Natividad Anthony Mai Yi Ouyang Nils Lambrecht Sandor Szabo Lisheng Ge Neil Hoa Maria G. Dacosta-Iyer |
| author_facet | Martin R. Jadus Josephine Natividad Anthony Mai Yi Ouyang Nils Lambrecht Sandor Szabo Lisheng Ge Neil Hoa Maria G. Dacosta-Iyer |
| author_sort | Martin R. Jadus |
| collection | DOAJ |
| description | Lung cancers remain one of the most common and deadly cancers in the world today (12.5% of newly diagnosed cancers) despite current advances in chemo- and radiation therapies. Often, by the time these tumors are diagnosed, they have already metastasized. These tumors demonstrate the classic hallmarks of cancer in that they have advanced defensive strategies allowing them to escape various standard oncological treatments. Immunotherapy is making inroads towards effectively treating other fatal cancers, such as melanoma, glioblastoma multiforme, and castrate-resistant prostate cancers. This paper will cover the escape mechanisms of bronchogenic lung cancer that must be overcome before they can be successfully treated. We also review the history of immunotherapy directed towards lung cancers. |
| format | Article |
| id | doaj-art-7ae43b3dd1c54ff88e2b60bb29ae4eb9 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-7ae43b3dd1c54ff88e2b60bb29ae4eb92025-02-03T06:14:03ZengWileyClinical and Developmental Immunology1740-25221740-25302012-01-01201210.1155/2012/160724160724Lung Cancer: A Classic Example of Tumor Escape and Progression While Providing Opportunities for Immunological InterventionMartin R. Jadus0Josephine Natividad1Anthony Mai2Yi Ouyang3Nils Lambrecht4Sandor Szabo5Lisheng Ge6Neil Hoa7Maria G. Dacosta-Iyer8Research Service, VA Long Beach Healthcare System, 5901 E. 7th Street, Long Beach, CA 90822, USAResearch Service, VA Long Beach Healthcare System, 5901 E. 7th Street, Long Beach, CA 90822, USAResearch Service, VA Long Beach Healthcare System, 5901 E. 7th Street, Long Beach, CA 90822, USAResearch Service, VA Long Beach Healthcare System, 5901 E. 7th Street, Long Beach, CA 90822, USAResearch Service, VA Long Beach Healthcare System, 5901 E. 7th Street, Long Beach, CA 90822, USADepartment of Pathology and Laboratory Medicine, University of California, Irvine, Irvine, CA 92697, USAResearch Service, VA Long Beach Healthcare System, 5901 E. 7th Street, Long Beach, CA 90822, USAResearch Service, VA Long Beach Healthcare System, 5901 E. 7th Street, Long Beach, CA 90822, USAResearch Service, VA Long Beach Healthcare System, 5901 E. 7th Street, Long Beach, CA 90822, USALung cancers remain one of the most common and deadly cancers in the world today (12.5% of newly diagnosed cancers) despite current advances in chemo- and radiation therapies. Often, by the time these tumors are diagnosed, they have already metastasized. These tumors demonstrate the classic hallmarks of cancer in that they have advanced defensive strategies allowing them to escape various standard oncological treatments. Immunotherapy is making inroads towards effectively treating other fatal cancers, such as melanoma, glioblastoma multiforme, and castrate-resistant prostate cancers. This paper will cover the escape mechanisms of bronchogenic lung cancer that must be overcome before they can be successfully treated. We also review the history of immunotherapy directed towards lung cancers.http://dx.doi.org/10.1155/2012/160724 |
| spellingShingle | Martin R. Jadus Josephine Natividad Anthony Mai Yi Ouyang Nils Lambrecht Sandor Szabo Lisheng Ge Neil Hoa Maria G. Dacosta-Iyer Lung Cancer: A Classic Example of Tumor Escape and Progression While Providing Opportunities for Immunological Intervention Clinical and Developmental Immunology |
| title | Lung Cancer: A Classic Example of Tumor Escape and Progression While Providing Opportunities for Immunological Intervention |
| title_full | Lung Cancer: A Classic Example of Tumor Escape and Progression While Providing Opportunities for Immunological Intervention |
| title_fullStr | Lung Cancer: A Classic Example of Tumor Escape and Progression While Providing Opportunities for Immunological Intervention |
| title_full_unstemmed | Lung Cancer: A Classic Example of Tumor Escape and Progression While Providing Opportunities for Immunological Intervention |
| title_short | Lung Cancer: A Classic Example of Tumor Escape and Progression While Providing Opportunities for Immunological Intervention |
| title_sort | lung cancer a classic example of tumor escape and progression while providing opportunities for immunological intervention |
| url | http://dx.doi.org/10.1155/2012/160724 |
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