A Hepatitis C virus genotype 1b post-transplant isolate with high replication efficiency in cell culture and its adaptation to infectious virus production in vitro and in vivo.

A Hepatitis C virus genotype 1b post-transplant isolate with high replication efficiency in cell culture and its adaptation to infectious virus production in vitro and in vivo.

Hepatitis C virus (HCV) is highly diverse and grouped into eight genotypes (gts). Infectious cell culture models are limited to a few subtypes and isolates, hampering the development of prophylactic vaccines. A consensus gt1b genome (termed GLT1) was generated from an HCV infected liver-transplanted...

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Main Authors: Christian Heuss, Paul Rothhaar, Rani Burm, Ji-Young Lee, Philipp Ralfs, Uta Haselmann, Luisa J Ströh, Ombretta Colasanti, Cong Si Tran, Noemi Schäfer, Paul Schnitzler, Uta Merle, Ralf Bartenschlager, Arvind H Patel, Frederik Graw, Thomas Krey, Vibor Laketa, Philip Meuleman, Volker Lohmann
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-06-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1010472&type=printable
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