Evaluation of serum Ferritin level in patients presenting with dysphagia: A hidden marker to diagnose Plummer Vinson syndrome
Objective: 1) To evaluate the serum ferritin level in patients presenting with dysphagia. 2) To determine the frequency of low serum ferritin in Plummer Vinson syndrome Methods: Cross sectional study conducted in Department of Otorhinolaryngology and Department of Chemical Pathology, Sheikh Zaye...
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Rawalpindi Medical University
2024-09-01
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| Series: | Journal of Rawalpindi Medical College |
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| Online Access: | https://www.journalrmc.com/index.php/JRMC/article/view/2582 |
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| author | Rukhsana Tumrani Afshan Qayum Kashif Munir Ahmad Ijlal Mehvish Sana |
| author_facet | Rukhsana Tumrani Afshan Qayum Kashif Munir Ahmad Ijlal Mehvish Sana |
| author_sort | Rukhsana Tumrani |
| collection | DOAJ |
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Objective:
1) To evaluate the serum ferritin level in patients presenting with dysphagia.
2) To determine the frequency of low serum ferritin in Plummer Vinson syndrome
Methods: Cross sectional study conducted in Department of Otorhinolaryngology and Department of Chemical Pathology, Sheikh Zayed Hospital, Rahim Yar khan from November 2022 to September 2023. Patients between 20 to 60 years of age, both genders, presenting with dysphagia in outdoor were included and subjected to the estimation of serum ferritin level and barium swallow to diagnose Plummer Vinson syndrome. Data was collected on predesigned proforma for different variables. Serum ferritin level was estimated on chemiluminescence based immunoassay analyzer in serum sample and low ferritin level was labelled on the basis of cut-off provided by the manufacturer i.e., 8ng/ml. Effect modifiers controlled through stratification and post-stratification chi square test used to see the statistically significant difference between subgroups. P value <0.05 was taken as significant.
Results: Mean age of the study subjects was 37.79±8.451years and 53(26.1%) were male and 150(73.9%) were females. Of the total 203 study subjects, 22(10.8%) were diagnosed as Plummer Vinson syndrome and among all these cases, 18(81.8%) were having low serum ferritin ≤8.0ng/ml with statistically significant difference between subgroups (p value <0.001).
Conclusion:
On the basis of our study, it is concluded that serum ferritin level can be a useful marker in patients of Plummer Vinson syndrome and it can help in early diagnosis and management of the patients to prevent its malignant transformation.
Key words:
Serum Ferritin, Dysphagia, Plummer Vinson syndrome
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| format | Article |
| id | doaj-art-7ac367023dd949ceb5f9db7a4361d5c0 |
| institution | Kabale University |
| issn | 1683-3562 1683-3570 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Rawalpindi Medical University |
| record_format | Article |
| series | Journal of Rawalpindi Medical College |
| spelling | doaj-art-7ac367023dd949ceb5f9db7a4361d5c02025-02-06T08:34:58ZengRawalpindi Medical UniversityJournal of Rawalpindi Medical College1683-35621683-35702024-09-0128310.37939/jrmc.v28i3.2582Evaluation of serum Ferritin level in patients presenting with dysphagia: A hidden marker to diagnose Plummer Vinson syndromeRukhsana Tumrani0Afshan QayumKashif MunirAhmad IjlalMehvish SanaAssistant Professor Chemical Pathology, Shalamar Medical and Dental College, Lahore Objective: 1) To evaluate the serum ferritin level in patients presenting with dysphagia. 2) To determine the frequency of low serum ferritin in Plummer Vinson syndrome Methods: Cross sectional study conducted in Department of Otorhinolaryngology and Department of Chemical Pathology, Sheikh Zayed Hospital, Rahim Yar khan from November 2022 to September 2023. Patients between 20 to 60 years of age, both genders, presenting with dysphagia in outdoor were included and subjected to the estimation of serum ferritin level and barium swallow to diagnose Plummer Vinson syndrome. Data was collected on predesigned proforma for different variables. Serum ferritin level was estimated on chemiluminescence based immunoassay analyzer in serum sample and low ferritin level was labelled on the basis of cut-off provided by the manufacturer i.e., 8ng/ml. Effect modifiers controlled through stratification and post-stratification chi square test used to see the statistically significant difference between subgroups. P value <0.05 was taken as significant. Results: Mean age of the study subjects was 37.79±8.451years and 53(26.1%) were male and 150(73.9%) were females. Of the total 203 study subjects, 22(10.8%) were diagnosed as Plummer Vinson syndrome and among all these cases, 18(81.8%) were having low serum ferritin ≤8.0ng/ml with statistically significant difference between subgroups (p value <0.001). Conclusion: On the basis of our study, it is concluded that serum ferritin level can be a useful marker in patients of Plummer Vinson syndrome and it can help in early diagnosis and management of the patients to prevent its malignant transformation. Key words: Serum Ferritin, Dysphagia, Plummer Vinson syndrome https://www.journalrmc.com/index.php/JRMC/article/view/2582Serum FerritinDysphagiaPlummer Vinson syndrome |
| spellingShingle | Rukhsana Tumrani Afshan Qayum Kashif Munir Ahmad Ijlal Mehvish Sana Evaluation of serum Ferritin level in patients presenting with dysphagia: A hidden marker to diagnose Plummer Vinson syndrome Journal of Rawalpindi Medical College Serum Ferritin Dysphagia Plummer Vinson syndrome |
| title | Evaluation of serum Ferritin level in patients presenting with dysphagia: A hidden marker to diagnose Plummer Vinson syndrome |
| title_full | Evaluation of serum Ferritin level in patients presenting with dysphagia: A hidden marker to diagnose Plummer Vinson syndrome |
| title_fullStr | Evaluation of serum Ferritin level in patients presenting with dysphagia: A hidden marker to diagnose Plummer Vinson syndrome |
| title_full_unstemmed | Evaluation of serum Ferritin level in patients presenting with dysphagia: A hidden marker to diagnose Plummer Vinson syndrome |
| title_short | Evaluation of serum Ferritin level in patients presenting with dysphagia: A hidden marker to diagnose Plummer Vinson syndrome |
| title_sort | evaluation of serum ferritin level in patients presenting with dysphagia a hidden marker to diagnose plummer vinson syndrome |
| topic | Serum Ferritin Dysphagia Plummer Vinson syndrome |
| url | https://www.journalrmc.com/index.php/JRMC/article/view/2582 |
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