Progression of ampC amplification during de novo amoxicillin resistance development in E. coli

Progression of ampC amplification during de novo amoxicillin resistance development in E. coli

ABSTRACT Beta-lactam antibiotics are the most applied antimicrobials in human and veterinarian health care. Hence, beta-lactam resistance is a major health problem. Gene amplification of AmpC beta-lactamase is a main contributor to de novo β-lactam resistance in Escherichia coli. However, the time c...

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Bibliographic Details
Main Authors: Luyuan Nong, Martijs Jonker, Wim de Leeuw, Meike T. Wortel, Benno ter Kuile
Format: Article
Language:English
Published: American Society for Microbiology 2025-02-01
Series:mBio
Subjects:
AmpC
beta-lactamase
gene amplification
resistance evolution
antimicrobial
IS1 element
Online Access:https://journals.asm.org/doi/10.1128/mbio.02982-24
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