Epidermodysplasia Verruciformis: A Clinicopathologic Review of Two Cases
Epidermodysplasia verruciformis (EV) is a rare autosomal recessive disease involving the immune system. It presents as pityriasis versicolor-like or warty papules, the onset being from early childhood at the face, dorsum of hands and feet. It can also occur as an acquired entity in patients with imm...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-01-01
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| Series: | Clinical Dermatology Review |
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| Online Access: | https://journals.lww.com/10.4103/cdr.cdr_103_22 |
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| author | Tummidi Santosh Tanya Sharma Deepti Joshi Dinesh Prasad Asati Sanjeev Vijay Choudhary Neelkamal Kapoor |
| author_facet | Tummidi Santosh Tanya Sharma Deepti Joshi Dinesh Prasad Asati Sanjeev Vijay Choudhary Neelkamal Kapoor |
| author_sort | Tummidi Santosh |
| collection | DOAJ |
| description | Epidermodysplasia verruciformis (EV) is a rare autosomal recessive disease involving the immune system. It presents as pityriasis versicolor-like or warty papules, the onset being from early childhood at the face, dorsum of hands and feet. It can also occur as an acquired entity in patients with immunocompromised status, human immunodeficiency virus (HIV) infection, and immunosuppressant therapy. Hereby, we report two cases of EV, histologically diagnosed on skin punch biopsy, both presented with a clinical history of macular/verrucous lesions in various sun-exposed body regions. One of the cases was diagnosed with squamous cell carcinoma (SCC) in situ from the lesion on the left forehead. EV is associated with beta-human papillomavirus infection and later the progression to malignancy. Early detection and preventive measures can help in the progression of the disease to Bowen’s disease or invasive SCC. |
| format | Article |
| id | doaj-art-7ac1deb7bbb744c7bdaed4ce2667e8e3 |
| institution | Kabale University |
| issn | 2542-551X 2542-5528 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Clinical Dermatology Review |
| spelling | doaj-art-7ac1deb7bbb744c7bdaed4ce2667e8e32025-02-06T05:07:41ZengWolters Kluwer Medknow PublicationsClinical Dermatology Review2542-551X2542-55282025-01-0191959810.4103/cdr.cdr_103_22Epidermodysplasia Verruciformis: A Clinicopathologic Review of Two CasesTummidi SantoshTanya SharmaDeepti JoshiDinesh Prasad AsatiSanjeev Vijay ChoudharyNeelkamal KapoorEpidermodysplasia verruciformis (EV) is a rare autosomal recessive disease involving the immune system. It presents as pityriasis versicolor-like or warty papules, the onset being from early childhood at the face, dorsum of hands and feet. It can also occur as an acquired entity in patients with immunocompromised status, human immunodeficiency virus (HIV) infection, and immunosuppressant therapy. Hereby, we report two cases of EV, histologically diagnosed on skin punch biopsy, both presented with a clinical history of macular/verrucous lesions in various sun-exposed body regions. One of the cases was diagnosed with squamous cell carcinoma (SCC) in situ from the lesion on the left forehead. EV is associated with beta-human papillomavirus infection and later the progression to malignancy. Early detection and preventive measures can help in the progression of the disease to Bowen’s disease or invasive SCC.https://journals.lww.com/10.4103/cdr.cdr_103_22epidermodysplasia verruciformishuman papillomavirusmalignancynonmelanoticskin biopsysquamous cell carcinoma |
| spellingShingle | Tummidi Santosh Tanya Sharma Deepti Joshi Dinesh Prasad Asati Sanjeev Vijay Choudhary Neelkamal Kapoor Epidermodysplasia Verruciformis: A Clinicopathologic Review of Two Cases Clinical Dermatology Review epidermodysplasia verruciformis human papillomavirus malignancy nonmelanotic skin biopsy squamous cell carcinoma |
| title | Epidermodysplasia Verruciformis: A Clinicopathologic Review of Two Cases |
| title_full | Epidermodysplasia Verruciformis: A Clinicopathologic Review of Two Cases |
| title_fullStr | Epidermodysplasia Verruciformis: A Clinicopathologic Review of Two Cases |
| title_full_unstemmed | Epidermodysplasia Verruciformis: A Clinicopathologic Review of Two Cases |
| title_short | Epidermodysplasia Verruciformis: A Clinicopathologic Review of Two Cases |
| title_sort | epidermodysplasia verruciformis a clinicopathologic review of two cases |
| topic | epidermodysplasia verruciformis human papillomavirus malignancy nonmelanotic skin biopsy squamous cell carcinoma |
| url | https://journals.lww.com/10.4103/cdr.cdr_103_22 |
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