Minibeam Radiation Therapy for Recurrent Mucosal Melanoma: An Eye-Opening Response

Minibeam Radiation Therapy for Recurrent Mucosal Melanoma: An Eye-Opening Response

We report a case of novel radiation treatment referred to as minibeam radiation therapy (MBRT) that was used to treat recurrent mucosal melanoma. The patient’s disease recurred after surgery, conventional radiation therapy, and 4 lines of systemic therapy, and then, the patient was referred to our c...

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Main Authors: Maddi A. Jacobson, MPAS, PA-C, Yasamin Sharifzadeh, MD, Arkadiusz Z. Dudek, MD, PhD, Svetomir N. Markovic, MD, PhD, Jeffrey E. Johnson, MD, Jonathan M. Morris, MD, Scott C. Lester, MD, Robert W. Mutter, MD, Michael P. Grams, PhD, Sean S. Park, MD, PhD
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Mayo Clinic Proceedings: Innovations, Quality & Outcomes
Online Access:http://www.sciencedirect.com/science/article/pii/S2542454825000517
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Summary:We report a case of novel radiation treatment referred to as minibeam radiation therapy (MBRT) that was used to treat recurrent mucosal melanoma. The patient’s disease recurred after surgery, conventional radiation therapy, and 4 lines of systemic therapy, and then, the patient was referred to our clinic. Despite substantial disease progression after multiple prior therapies, a complete metabolic and clinical response, along with an improved quality of life and performance status, was achieved after 2 treatments of MBRT. Additionally, disease response was noted in an unirradiated abdominal metastasis. The MBRT treatments were well-tolerated, with minimal toxicity reported more than 6 months posttreatment. This case highlights the potential of MBRT as a completely novel form of radiation therapy that warrants further study.
ISSN:2542-4548

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