Inter-protomer opening cooperativity of envelope trimers positively correlates with HIV-1 entry stoichiometry

Inter-protomer opening cooperativity of envelope trimers positively correlates with HIV-1 entry stoichiometry

ABSTRACT HIV-1 entry to host cells is fulfilled by fusion, mediated by surface glycoprotein envelope (Env) trimers upon interaction with host receptors. The entry stoichiometry (T) defining the number of Env trimers required for fusion remains elusive. Stoichiometry was previously estimated using ma...

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Bibliographic Details
Main Authors: Revansiddha H. Katte, Wang Xu, Yang Han, Xinyu Hong, Maolin Lu
Format: Article
Language:English
Published: American Society for Microbiology 2025-04-01
Series:mBio
Subjects:
HIV-1
virus entry
envelope
trimer
protomer
stoichiometry
Online Access:https://journals.asm.org/doi/10.1128/mbio.02754-24
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