Exploring glycolytic enzymes in disease: potential biomarkers and therapeutic targets in neurodegeneration, cancer and parasitic infections
Glycolysis, present in most organisms, is evolutionarily one of the oldest metabolic pathways. It has great relevance at a physiological level because it is responsible for generating ATP in the cell through the conversion of glucose into pyruvate and reducing nicotinamide adenine dinucleotide (NADH...
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| Language: | English |
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The Royal Society
2025-02-01
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| Series: | Open Biology |
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| Online Access: | https://royalsocietypublishing.org/doi/10.1098/rsob.240239 |
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| author | Maura Rojas-Pirela Diego Andrade-Alviárez Verónica Rojas Miguel Marcos Daniel Salete-Granado Marirene Chacón-Arnaude María Á. Pérez-Nieto Ulrike Kemmerling Juan Luis Concepción Paul A. M. Michels Wilfredo Quiñones |
| author_facet | Maura Rojas-Pirela Diego Andrade-Alviárez Verónica Rojas Miguel Marcos Daniel Salete-Granado Marirene Chacón-Arnaude María Á. Pérez-Nieto Ulrike Kemmerling Juan Luis Concepción Paul A. M. Michels Wilfredo Quiñones |
| author_sort | Maura Rojas-Pirela |
| collection | DOAJ |
| description | Glycolysis, present in most organisms, is evolutionarily one of the oldest metabolic pathways. It has great relevance at a physiological level because it is responsible for generating ATP in the cell through the conversion of glucose into pyruvate and reducing nicotinamide adenine dinucleotide (NADH) (that may be fed into the electron chain in the mitochondria to produce additional ATP by oxidative phosphorylation), as well as for producing intermediates that can serve as substrates for other metabolic processes. Glycolysis takes place through 10 consecutive chemical reactions, each of which is catalysed by a specific enzyme. Although energy transduction by glucose metabolism is the main function of this pathway, involvement in virulence, growth, pathogen–host interactions, immunomodulation and adaptation to environmental conditions are other functions attributed to this metabolic pathway. In humans, where glycolysis occurs mainly in the cytosol, the mislocalization of some glycolytic enzymes in various other subcellular locations, as well as alterations in their expression and regulation, has been associated with the development and progression of various diseases. In this review, we describe the role of glycolytic enzymes in the pathogenesis of diseases of clinical interest. In addition, the potential role of these enzymes as targets for drug development and their potential for use as diagnostic and prognostic markers of some pathologies are also discussed. |
| format | Article |
| id | doaj-art-7aa0985fdbb842769ffe0eb87e6b75de |
| institution | Kabale University |
| issn | 2046-2441 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | The Royal Society |
| record_format | Article |
| series | Open Biology |
| spelling | doaj-art-7aa0985fdbb842769ffe0eb87e6b75de2025-02-05T15:17:01ZengThe Royal SocietyOpen Biology2046-24412025-02-0115210.1098/rsob.240239Exploring glycolytic enzymes in disease: potential biomarkers and therapeutic targets in neurodegeneration, cancer and parasitic infectionsMaura Rojas-Pirela0Diego Andrade-Alviárez1Verónica Rojas2Miguel Marcos3Daniel Salete-Granado4Marirene Chacón-Arnaude5María Á. Pérez-Nieto6Ulrike Kemmerling7Juan Luis Concepción8Paul A. M. Michels9Wilfredo Quiñones10Instituto de Investigación Biomédica de Salamanca (IBSAL), Salamanca 37007, SpainLaboratorio de Enzimología de Parásitos, Departamento de Biología, Facultad de Ciencias, Universidad de Los Andes, Mérida 5101, VenezuelaInstituto de Biología, Facultad de Ciencias, Pontificia Universidad Católica de Valparaíso, Valparaíso 2373223, ChileInstituto de Investigación Biomédica de Salamanca (IBSAL), Salamanca 37007, SpainInstituto de Investigación Biomédica de Salamanca (IBSAL), Salamanca 37007, SpainLaboratorio de Enzimología de Parásitos, Departamento de Biología, Facultad de Ciencias, Universidad de Los Andes, Mérida 5101, VenezuelaUnidad de Medicina Molecular, Departamento de Medicina, Universidad de Salamanca, Salamanca 37007, SpainInstituto de Ciencias Biomédicas, Universidad de Chile, Facultad de Medicina, Santiago de Chile 8380453, ChileLaboratorio de Enzimología de Parásitos, Departamento de Biología, Facultad de Ciencias, Universidad de Los Andes, Mérida 5101, VenezuelaSchool of Biological Sciences, University of Edinburgh, The King’s Buildings, Edinburgh EH9 3FL, UKLaboratorio de Enzimología de Parásitos, Departamento de Biología, Facultad de Ciencias, Universidad de Los Andes, Mérida 5101, VenezuelaGlycolysis, present in most organisms, is evolutionarily one of the oldest metabolic pathways. It has great relevance at a physiological level because it is responsible for generating ATP in the cell through the conversion of glucose into pyruvate and reducing nicotinamide adenine dinucleotide (NADH) (that may be fed into the electron chain in the mitochondria to produce additional ATP by oxidative phosphorylation), as well as for producing intermediates that can serve as substrates for other metabolic processes. Glycolysis takes place through 10 consecutive chemical reactions, each of which is catalysed by a specific enzyme. Although energy transduction by glucose metabolism is the main function of this pathway, involvement in virulence, growth, pathogen–host interactions, immunomodulation and adaptation to environmental conditions are other functions attributed to this metabolic pathway. In humans, where glycolysis occurs mainly in the cytosol, the mislocalization of some glycolytic enzymes in various other subcellular locations, as well as alterations in their expression and regulation, has been associated with the development and progression of various diseases. In this review, we describe the role of glycolytic enzymes in the pathogenesis of diseases of clinical interest. In addition, the potential role of these enzymes as targets for drug development and their potential for use as diagnostic and prognostic markers of some pathologies are also discussed.https://royalsocietypublishing.org/doi/10.1098/rsob.240239glycolysispathogenesis of diseasesprognosticdiagnostictherapeutic |
| spellingShingle | Maura Rojas-Pirela Diego Andrade-Alviárez Verónica Rojas Miguel Marcos Daniel Salete-Granado Marirene Chacón-Arnaude María Á. Pérez-Nieto Ulrike Kemmerling Juan Luis Concepción Paul A. M. Michels Wilfredo Quiñones Exploring glycolytic enzymes in disease: potential biomarkers and therapeutic targets in neurodegeneration, cancer and parasitic infections Open Biology glycolysis pathogenesis of diseases prognostic diagnostic therapeutic |
| title | Exploring glycolytic enzymes in disease: potential biomarkers and therapeutic targets in neurodegeneration, cancer and parasitic infections |
| title_full | Exploring glycolytic enzymes in disease: potential biomarkers and therapeutic targets in neurodegeneration, cancer and parasitic infections |
| title_fullStr | Exploring glycolytic enzymes in disease: potential biomarkers and therapeutic targets in neurodegeneration, cancer and parasitic infections |
| title_full_unstemmed | Exploring glycolytic enzymes in disease: potential biomarkers and therapeutic targets in neurodegeneration, cancer and parasitic infections |
| title_short | Exploring glycolytic enzymes in disease: potential biomarkers and therapeutic targets in neurodegeneration, cancer and parasitic infections |
| title_sort | exploring glycolytic enzymes in disease potential biomarkers and therapeutic targets in neurodegeneration cancer and parasitic infections |
| topic | glycolysis pathogenesis of diseases prognostic diagnostic therapeutic |
| url | https://royalsocietypublishing.org/doi/10.1098/rsob.240239 |
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