Cohort profile: the Western Cape Pregnancy Exposure Registry (WCPER)
Purpose The Western Cape Pregnancy Exposure Registry (PER) was established at two public sector healthcare sentinel sites in the Western Cape province, South Africa, to provide ongoing surveillance of drug exposures in pregnancy and associations with pregnancy outcomes.Participants Established in 20...
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2022-06-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/12/6/e060205.full |
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| author | Landon Myer Amy L Slogrove Ushma Mehta Mary-Ann Davies Max Kroon Greg Petro Alexa Heekes Andrew Boulle Karen Fieggen Chantal Stewart Ayesha Osman Natasha Rhoda Emma Kalk Florence Phelanyane Jonathan Euvrard Stefan Gebhardt Kim Anderson |
| author_facet | Landon Myer Amy L Slogrove Ushma Mehta Mary-Ann Davies Max Kroon Greg Petro Alexa Heekes Andrew Boulle Karen Fieggen Chantal Stewart Ayesha Osman Natasha Rhoda Emma Kalk Florence Phelanyane Jonathan Euvrard Stefan Gebhardt Kim Anderson |
| author_sort | Landon Myer |
| collection | DOAJ |
| description | Purpose The Western Cape Pregnancy Exposure Registry (PER) was established at two public sector healthcare sentinel sites in the Western Cape province, South Africa, to provide ongoing surveillance of drug exposures in pregnancy and associations with pregnancy outcomes.Participants Established in 2016, all women attending their first antenatal visit at primary care obstetric facilities were enrolled and followed to pregnancy outcome regardless of the site (ie, primary, secondary, tertiary facility). Routine operational obstetric and medical data are digitised from the clinical stationery at the healthcare facilities. Data collection has been integrated into existing services and information platforms and supports routine operations. The PER is situated within the Provincial Health Data Centre, an information exchange that harmonises and consolidates all health-related electronic data in the province. Data are contributed via linkage across a unique identifier. This relationship limits the missing data in the PER, allows validation and avoids misclassification in the population-level data set.Findings to date Approximately 5000 and 3500 pregnant women enter the data set annually at the urban and rural sites, respectively. As of August 2021, >30 000 pregnancies have been recorded and outcomes have been determined for 93%. Analysis of key obstetric and neonatal health indicators derived from the PER are consistent with the aggregate data in the District Health Information System.Future plans This represents significant infrastructure, able to address clinical and epidemiological concerns in a low/middle-income setting. |
| format | Article |
| id | doaj-art-7a9b1c4520dc4ee7b73737284da6499a |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2022-06-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-7a9b1c4520dc4ee7b73737284da6499a2025-01-28T04:35:09ZengBMJ Publishing GroupBMJ Open2044-60552022-06-0112610.1136/bmjopen-2021-060205Cohort profile: the Western Cape Pregnancy Exposure Registry (WCPER)Landon Myer0Amy L Slogrove1Ushma Mehta2Mary-Ann Davies3Max Kroon4Greg Petro5Alexa Heekes6Andrew Boulle7Karen Fieggen8Chantal Stewart9Ayesha Osman10Natasha Rhoda11Emma Kalk12Florence Phelanyane13Jonathan Euvrard14Stefan Gebhardt15Kim Anderson167 Division of Epidemiology and Biostatistics and Centre for Infectious Diseases Epidemiology and Research, University of Cape Town Faculty of Health Sciences, Observatory, South AfricaDeparmtment of Paediatrics & Child Health, Stellenbosch University Faculty of Medicine and Health Sciences, Cape Town, Western Cape, South AfricaCentre for Infectious Disease Epidemiology and Research, University of Cape Town, Cape Town, Western Cape, South AfricaCentre for Infectious Disease Epidemiology & Research, School of Public Health, Faculty of Health Sciences, University of Cape Town, Cape Town, South AfricaDepartment of Paediatrics & Child Health, University of Cape Town Faculty of Health Sciences, Cape Town, South AfricaDepartment of Obstetrics & Gynaecology, University of Cape Town Faculty of Health Sciences, Cape Town, South AfricaCentre for Infectious Disease Epidemiology & Research, University of Cape Town Faculty of Health Sciences, Cape Town, South AfricaCentre for Infectious Disease Epidemiology and Research (CIDER), University of Cape Town, Cape Town, South AfricaDivision of Human Genetics, University of Cape Town Faculty of Health Sciences, Cape Town, South AfricaDepartment of Obstetrics & Gynaecology, University of Cape Town Faculty of Health Sciences, Cape Town, South AfricaDepartment of Obstetrics & Gynaecology, University of Cape Town Faculty of Health Sciences, Cape Town, South AfricaDepartment of Paediatrics & Child Health, University of Cape Town Faculty of Health Sciences, Cape Town, South AfricaCentre for Infectious Disease Epidemiology & Research, University of Cape Town Faculty of Health Sciences, Cape Town, South AfricaCentre for Infectious Disease Epidemiology and Research (CIDER), School of Public Health and Family Medicine, Faculty of Health Sciences, University of Cape Town, Observatory, South AfricaCentre for Infectious Disease Epidemiology & Research, University of Cape Town Faculty of Health Sciences, Cape Town, South AfricaDepartment of Obstetrics & Gynaecology, Stellenbosch University, Stellenbosch, South AfricaCentre for Infectious Disease Epidemiology & Research, University of Cape Town Faculty of Health Sciences, Cape Town, South AfricaPurpose The Western Cape Pregnancy Exposure Registry (PER) was established at two public sector healthcare sentinel sites in the Western Cape province, South Africa, to provide ongoing surveillance of drug exposures in pregnancy and associations with pregnancy outcomes.Participants Established in 2016, all women attending their first antenatal visit at primary care obstetric facilities were enrolled and followed to pregnancy outcome regardless of the site (ie, primary, secondary, tertiary facility). Routine operational obstetric and medical data are digitised from the clinical stationery at the healthcare facilities. Data collection has been integrated into existing services and information platforms and supports routine operations. The PER is situated within the Provincial Health Data Centre, an information exchange that harmonises and consolidates all health-related electronic data in the province. Data are contributed via linkage across a unique identifier. This relationship limits the missing data in the PER, allows validation and avoids misclassification in the population-level data set.Findings to date Approximately 5000 and 3500 pregnant women enter the data set annually at the urban and rural sites, respectively. As of August 2021, >30 000 pregnancies have been recorded and outcomes have been determined for 93%. Analysis of key obstetric and neonatal health indicators derived from the PER are consistent with the aggregate data in the District Health Information System.Future plans This represents significant infrastructure, able to address clinical and epidemiological concerns in a low/middle-income setting.https://bmjopen.bmj.com/content/12/6/e060205.full |
| spellingShingle | Landon Myer Amy L Slogrove Ushma Mehta Mary-Ann Davies Max Kroon Greg Petro Alexa Heekes Andrew Boulle Karen Fieggen Chantal Stewart Ayesha Osman Natasha Rhoda Emma Kalk Florence Phelanyane Jonathan Euvrard Stefan Gebhardt Kim Anderson Cohort profile: the Western Cape Pregnancy Exposure Registry (WCPER) BMJ Open |
| title | Cohort profile: the Western Cape Pregnancy Exposure Registry (WCPER) |
| title_full | Cohort profile: the Western Cape Pregnancy Exposure Registry (WCPER) |
| title_fullStr | Cohort profile: the Western Cape Pregnancy Exposure Registry (WCPER) |
| title_full_unstemmed | Cohort profile: the Western Cape Pregnancy Exposure Registry (WCPER) |
| title_short | Cohort profile: the Western Cape Pregnancy Exposure Registry (WCPER) |
| title_sort | cohort profile the western cape pregnancy exposure registry wcper |
| url | https://bmjopen.bmj.com/content/12/6/e060205.full |
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