Inflammatory Bowel Disease with Cytoplasmic-Staining Antineutrophil Cytoplasmic Antibody and Extensive Colitis
A cohort of 18 patients with inflammatory bowel disease who were characterized by the presence of cytoplasmic-staining antineutrophil cytoplasmic antibody (cANCA) and extensive colitis is reported. Almost half were Indo-Canadians, and atypical perinuclear-staining antineutrophil cytoplasmic antibody...
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| Format: | Article |
| Language: | English |
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Wiley
1998-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/1998/186063 |
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| _version_ | 1832551400401272832 |
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| author | Hugh James Freeman |
| author_facet | Hugh James Freeman |
| author_sort | Hugh James Freeman |
| collection | DOAJ |
| description | A cohort of 18 patients with inflammatory bowel disease who were characterized by the presence of cytoplasmic-staining antineutrophil cytoplasmic antibody (cANCA) and extensive colitis is reported. Almost half were Indo-Canadians, and atypical perinuclear-staining antineutrophil cytoplasmic antibody was also detected in five (28%), similar to the detection rate for Crohn's disease and other less commonly detected forms of colitis, such as lymphocytic or collagenous colitis. Careful pathological review of all endoscopic biopsies and surgically resected colonic tissues did not reveal evidence of vasculitis or so-called 'palisading' granulomas, which is a typical pathological change of Wegener's granulomatosis, an entity that has been traditionally characterized by the detection of cANCA. This report describes 18 patients with extensive colitis and the seromarker cANCA but without clinical features or histological evidence of vasculitis. |
| format | Article |
| id | doaj-art-7a8d3a001e0648a18b36b02ef91b9c9e |
| institution | Kabale University |
| issn | 0835-7900 |
| language | English |
| publishDate | 1998-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-7a8d3a001e0648a18b36b02ef91b9c9e2025-02-03T06:01:29ZengWileyCanadian Journal of Gastroenterology0835-79001998-01-0112427928210.1155/1998/186063Inflammatory Bowel Disease with Cytoplasmic-Staining Antineutrophil Cytoplasmic Antibody and Extensive ColitisHugh James Freeman0Department of Medicine (Gastroenterology), University of British Columbia, Vancouver, British Columbia, CanadaA cohort of 18 patients with inflammatory bowel disease who were characterized by the presence of cytoplasmic-staining antineutrophil cytoplasmic antibody (cANCA) and extensive colitis is reported. Almost half were Indo-Canadians, and atypical perinuclear-staining antineutrophil cytoplasmic antibody was also detected in five (28%), similar to the detection rate for Crohn's disease and other less commonly detected forms of colitis, such as lymphocytic or collagenous colitis. Careful pathological review of all endoscopic biopsies and surgically resected colonic tissues did not reveal evidence of vasculitis or so-called 'palisading' granulomas, which is a typical pathological change of Wegener's granulomatosis, an entity that has been traditionally characterized by the detection of cANCA. This report describes 18 patients with extensive colitis and the seromarker cANCA but without clinical features or histological evidence of vasculitis.http://dx.doi.org/10.1155/1998/186063 |
| spellingShingle | Hugh James Freeman Inflammatory Bowel Disease with Cytoplasmic-Staining Antineutrophil Cytoplasmic Antibody and Extensive Colitis Canadian Journal of Gastroenterology |
| title | Inflammatory Bowel Disease with Cytoplasmic-Staining Antineutrophil Cytoplasmic Antibody and Extensive Colitis |
| title_full | Inflammatory Bowel Disease with Cytoplasmic-Staining Antineutrophil Cytoplasmic Antibody and Extensive Colitis |
| title_fullStr | Inflammatory Bowel Disease with Cytoplasmic-Staining Antineutrophil Cytoplasmic Antibody and Extensive Colitis |
| title_full_unstemmed | Inflammatory Bowel Disease with Cytoplasmic-Staining Antineutrophil Cytoplasmic Antibody and Extensive Colitis |
| title_short | Inflammatory Bowel Disease with Cytoplasmic-Staining Antineutrophil Cytoplasmic Antibody and Extensive Colitis |
| title_sort | inflammatory bowel disease with cytoplasmic staining antineutrophil cytoplasmic antibody and extensive colitis |
| url | http://dx.doi.org/10.1155/1998/186063 |
| work_keys_str_mv | AT hughjamesfreeman inflammatoryboweldiseasewithcytoplasmicstainingantineutrophilcytoplasmicantibodyandextensivecolitis |