Stability and Bifurcation Analysis for a Delay Differential Equation of Hepatitis B Virus Infection

The stability and bifurcation analysis for a delay differential equation of hepatitis B virus infection is investigated. We show the existence of nonnegative equilibria under some appropriated conditions. The existence of the Hopf bifurcation with delay τ at the endemic equilibria is established by...

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Main Authors: Xinchao Yang, Xiju Zong, Xingong Cheng, Zhenlai Han
Format: Article
Language:English
Published: Wiley 2013-01-01
Series:Journal of Applied Mathematics
Online Access:http://dx.doi.org/10.1155/2013/875783
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author Xinchao Yang
Xiju Zong
Xingong Cheng
Zhenlai Han
author_facet Xinchao Yang
Xiju Zong
Xingong Cheng
Zhenlai Han
author_sort Xinchao Yang
collection DOAJ
description The stability and bifurcation analysis for a delay differential equation of hepatitis B virus infection is investigated. We show the existence of nonnegative equilibria under some appropriated conditions. The existence of the Hopf bifurcation with delay τ at the endemic equilibria is established by analyzing the distribution of the characteristic values. The explicit formulae which determine the direction of the bifurcations, stability, and the other properties of the bifurcating periodic solutions are given by using the normal form theory and the center manifold theorem. Numerical simulation verifies the theoretical results.
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institution Kabale University
issn 1110-757X
1687-0042
language English
publishDate 2013-01-01
publisher Wiley
record_format Article
series Journal of Applied Mathematics
spelling doaj-art-7a893114d61e419193578ed18eccee0f2025-02-03T05:43:39ZengWileyJournal of Applied Mathematics1110-757X1687-00422013-01-01201310.1155/2013/875783875783Stability and Bifurcation Analysis for a Delay Differential Equation of Hepatitis B Virus InfectionXinchao Yang0Xiju Zong1Xingong Cheng2Zhenlai Han3School of Medical and Life Science, University of Jinan, Jinan, Shandong 250022, ChinaSchool of Electrical Engineering, University of Jinan, Jinan, Shandong 250022, ChinaSchool of Electrical Engineering, University of Jinan, Jinan, Shandong 250022, ChinaSchool of Science, University of Jinan, Jinan, Shandong 250022, ChinaThe stability and bifurcation analysis for a delay differential equation of hepatitis B virus infection is investigated. We show the existence of nonnegative equilibria under some appropriated conditions. The existence of the Hopf bifurcation with delay τ at the endemic equilibria is established by analyzing the distribution of the characteristic values. The explicit formulae which determine the direction of the bifurcations, stability, and the other properties of the bifurcating periodic solutions are given by using the normal form theory and the center manifold theorem. Numerical simulation verifies the theoretical results.http://dx.doi.org/10.1155/2013/875783
spellingShingle Xinchao Yang
Xiju Zong
Xingong Cheng
Zhenlai Han
Stability and Bifurcation Analysis for a Delay Differential Equation of Hepatitis B Virus Infection
Journal of Applied Mathematics
title Stability and Bifurcation Analysis for a Delay Differential Equation of Hepatitis B Virus Infection
title_full Stability and Bifurcation Analysis for a Delay Differential Equation of Hepatitis B Virus Infection
title_fullStr Stability and Bifurcation Analysis for a Delay Differential Equation of Hepatitis B Virus Infection
title_full_unstemmed Stability and Bifurcation Analysis for a Delay Differential Equation of Hepatitis B Virus Infection
title_short Stability and Bifurcation Analysis for a Delay Differential Equation of Hepatitis B Virus Infection
title_sort stability and bifurcation analysis for a delay differential equation of hepatitis b virus infection
url http://dx.doi.org/10.1155/2013/875783
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AT xijuzong stabilityandbifurcationanalysisforadelaydifferentialequationofhepatitisbvirusinfection
AT xingongcheng stabilityandbifurcationanalysisforadelaydifferentialequationofhepatitisbvirusinfection
AT zhenlaihan stabilityandbifurcationanalysisforadelaydifferentialequationofhepatitisbvirusinfection