Epigenetic Mechanisms in the Transcriptional Regulation of Circadian Rhythm in Mammals
Almost all organisms, from the simplest bacteria to advanced mammals, have<br>a near 24 h circadian rhythm. Circadian rhythms are highly conserved across different life forms and are regulated by circadian genes as well as by related transcription factors. Transcription factors are fundamental...
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2025-01-01
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| author | Wei Mao Xingnan Ge Qianping Chen Jia-Da Li |
| author_facet | Wei Mao Xingnan Ge Qianping Chen Jia-Da Li |
| author_sort | Wei Mao |
| collection | DOAJ |
| description | Almost all organisms, from the simplest bacteria to advanced mammals, have<br>a near 24 h circadian rhythm. Circadian rhythms are highly conserved across different life forms and are regulated by circadian genes as well as by related transcription factors. Transcription factors are fundamental to circadian rhythms, influencing gene expression, behavior in plants and animals, and human diseases. This review examines the foundational research on transcriptional regulation of circadian rhythms, emphasizing histone modifications, chromatin remodeling, and Pol II pausing control. These studies have enhanced our understanding of transcriptional regulation within biological circadian rhythms and the importance of circadian biology in human health. Finally, we summarize the progress and challenges in these three areas of regulation to move the field forward. |
| format | Article |
| id | doaj-art-7a7e6a0c441041378eecc9c5c8f9f0df |
| institution | Kabale University |
| issn | 2079-7737 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
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| series | Biology |
| spelling | doaj-art-7a7e6a0c441041378eecc9c5c8f9f0df2025-01-24T13:23:24ZengMDPI AGBiology2079-77372025-01-011414210.3390/biology14010042Epigenetic Mechanisms in the Transcriptional Regulation of Circadian Rhythm in MammalsWei Mao0Xingnan Ge1Qianping Chen2Jia-Da Li3Department of Radiation Oncology, Zhejiang Cancer Hospital, Hangzhou 310000, ChinaDepartment of Radiation Oncology, Zhejiang Cancer Hospital, Hangzhou 310000, ChinaDepartment of Radiation Oncology, Zhejiang Cancer Hospital, Hangzhou 310000, ChinaCenter for Medical Genetics, School of Life Sciences, Central South University, Changsha 410078, ChinaAlmost all organisms, from the simplest bacteria to advanced mammals, have<br>a near 24 h circadian rhythm. Circadian rhythms are highly conserved across different life forms and are regulated by circadian genes as well as by related transcription factors. Transcription factors are fundamental to circadian rhythms, influencing gene expression, behavior in plants and animals, and human diseases. This review examines the foundational research on transcriptional regulation of circadian rhythms, emphasizing histone modifications, chromatin remodeling, and Pol II pausing control. These studies have enhanced our understanding of transcriptional regulation within biological circadian rhythms and the importance of circadian biology in human health. Finally, we summarize the progress and challenges in these three areas of regulation to move the field forward.https://www.mdpi.com/2079-7737/14/1/42circadian rhythmstranscriptional regulationhistone modificationchromatin remodelingPol II pausing control |
| spellingShingle | Wei Mao Xingnan Ge Qianping Chen Jia-Da Li Epigenetic Mechanisms in the Transcriptional Regulation of Circadian Rhythm in Mammals Biology circadian rhythms transcriptional regulation histone modification chromatin remodeling Pol II pausing control |
| title | Epigenetic Mechanisms in the Transcriptional Regulation of Circadian Rhythm in Mammals |
| title_full | Epigenetic Mechanisms in the Transcriptional Regulation of Circadian Rhythm in Mammals |
| title_fullStr | Epigenetic Mechanisms in the Transcriptional Regulation of Circadian Rhythm in Mammals |
| title_full_unstemmed | Epigenetic Mechanisms in the Transcriptional Regulation of Circadian Rhythm in Mammals |
| title_short | Epigenetic Mechanisms in the Transcriptional Regulation of Circadian Rhythm in Mammals |
| title_sort | epigenetic mechanisms in the transcriptional regulation of circadian rhythm in mammals |
| topic | circadian rhythms transcriptional regulation histone modification chromatin remodeling Pol II pausing control |
| url | https://www.mdpi.com/2079-7737/14/1/42 |
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