Fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAPs) and mortality among survivors of liver cirrhosis: a prospective cohort study
Abstract Background Cirrhosis is a medical condition marked by persistent liver damage, which leads to the development of fibrous tissue and compromised liver function. In the present study, we decided to investigate the possibility of a connection between the consumption of fermentable olig-, di-,...
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BMC
2025-01-01
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| Series: | Nutrition Journal |
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| Online Access: | https://doi.org/10.1186/s12937-025-01086-9 |
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| author | Danial Fotros Azita Hekmatdoost Fereshteh Pashayee-khamene Sara Karimi Saleheh Ahmadzadeh Mehdi Saberifiroozi Behzad Hatami Zahra Yari |
| author_facet | Danial Fotros Azita Hekmatdoost Fereshteh Pashayee-khamene Sara Karimi Saleheh Ahmadzadeh Mehdi Saberifiroozi Behzad Hatami Zahra Yari |
| author_sort | Danial Fotros |
| collection | DOAJ |
| description | Abstract Background Cirrhosis is a medical condition marked by persistent liver damage, which leads to the development of fibrous tissue and compromised liver function. In the present study, we decided to investigate the possibility of a connection between the consumption of fermentable olig-, di-, monosaccharides, and polyols (FODMAPs) and mortality rates in cirrhotic patients by utilizing data obtained from a prospective cohort study. Methods This cohort study enrolled 166 ambulatory patients from two hospitals in Tehran, Iran, between 2016 and 2018, and followed them up for 5 48 months until April 30, 2022. During the 3,955 person-months of follow-up, 43 fatalities were recorded (36 men and 7 women). The study classified participants into three groups based on their FODMAPs consumption and assessed the risk of mortality using Cox proportional hazards regression models. Results Total FODMAPs intake was associated with increased overall mortality risk (T3 vs. T1, HR = 3.5; 95%CI: 1.05, 11.7; P-trend = 0.036). This significant trend was also observed for total fructans (T3 vs. T1, HR = 5.15; 95% CI: 1.15, 23.2; P-trend = 0.006) and fructose (T3 vs. T1, HR = 5.55; 95% CI: 0.54, 57.14; P-trend = 0.018). Mortality risk was U-shaped with galactooligosaccharide intake, a lower mortality risk was observed with lactose intake and a higher mortality risk with polyols intake, although these associations did not reach statistical significance. Conclusion In conclusion, this study highlights a higher risk of mortality with higher intake of fructans, excess fructose and total FODMAPs. |
| format | Article |
| id | doaj-art-7a72d83a87e841aa9214fc82b4690aaf |
| institution | Kabale University |
| issn | 1475-2891 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Nutrition Journal |
| spelling | doaj-art-7a72d83a87e841aa9214fc82b4690aaf2025-01-26T12:16:14ZengBMCNutrition Journal1475-28912025-01-012411910.1186/s12937-025-01086-9Fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAPs) and mortality among survivors of liver cirrhosis: a prospective cohort studyDanial Fotros0Azita Hekmatdoost1Fereshteh Pashayee-khamene2Sara Karimi3Saleheh Ahmadzadeh4Mehdi Saberifiroozi5Behzad Hatami6Zahra Yari7Clinical Nutrition and dietetics Department, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical SciencesClinical Nutrition and dietetics Department, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical SciencesStudent Research Committee, Ahvaz Jundishapur University of Medical SciencesClinical Nutrition and dietetics Department, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical SciencesClinical Nutrition and dietetics Department, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical SciencesLiver and Pancreatobiliary Research Center, Digestive Disease Research Institute, Shariati Hospital, Tehran University of Medical SciencesGastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical SciencesDepartment of Nutrition Research, National Nutrition and Food Technology Research Institute and Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical SciencesAbstract Background Cirrhosis is a medical condition marked by persistent liver damage, which leads to the development of fibrous tissue and compromised liver function. In the present study, we decided to investigate the possibility of a connection between the consumption of fermentable olig-, di-, monosaccharides, and polyols (FODMAPs) and mortality rates in cirrhotic patients by utilizing data obtained from a prospective cohort study. Methods This cohort study enrolled 166 ambulatory patients from two hospitals in Tehran, Iran, between 2016 and 2018, and followed them up for 5 48 months until April 30, 2022. During the 3,955 person-months of follow-up, 43 fatalities were recorded (36 men and 7 women). The study classified participants into three groups based on their FODMAPs consumption and assessed the risk of mortality using Cox proportional hazards regression models. Results Total FODMAPs intake was associated with increased overall mortality risk (T3 vs. T1, HR = 3.5; 95%CI: 1.05, 11.7; P-trend = 0.036). This significant trend was also observed for total fructans (T3 vs. T1, HR = 5.15; 95% CI: 1.15, 23.2; P-trend = 0.006) and fructose (T3 vs. T1, HR = 5.55; 95% CI: 0.54, 57.14; P-trend = 0.018). Mortality risk was U-shaped with galactooligosaccharide intake, a lower mortality risk was observed with lactose intake and a higher mortality risk with polyols intake, although these associations did not reach statistical significance. Conclusion In conclusion, this study highlights a higher risk of mortality with higher intake of fructans, excess fructose and total FODMAPs.https://doi.org/10.1186/s12937-025-01086-9FODMAPsCirrhosisMortalityCohort study |
| spellingShingle | Danial Fotros Azita Hekmatdoost Fereshteh Pashayee-khamene Sara Karimi Saleheh Ahmadzadeh Mehdi Saberifiroozi Behzad Hatami Zahra Yari Fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAPs) and mortality among survivors of liver cirrhosis: a prospective cohort study Nutrition Journal FODMAPs Cirrhosis Mortality Cohort study |
| title | Fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAPs) and mortality among survivors of liver cirrhosis: a prospective cohort study |
| title_full | Fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAPs) and mortality among survivors of liver cirrhosis: a prospective cohort study |
| title_fullStr | Fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAPs) and mortality among survivors of liver cirrhosis: a prospective cohort study |
| title_full_unstemmed | Fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAPs) and mortality among survivors of liver cirrhosis: a prospective cohort study |
| title_short | Fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAPs) and mortality among survivors of liver cirrhosis: a prospective cohort study |
| title_sort | fermentable oligosaccharides disaccharides monosaccharides and polyols fodmaps and mortality among survivors of liver cirrhosis a prospective cohort study |
| topic | FODMAPs Cirrhosis Mortality Cohort study |
| url | https://doi.org/10.1186/s12937-025-01086-9 |
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