Interneuron migration impairment and brain region-specific DNA damage response following irradiation during early neurogenesis in mice

Interneuron migration impairment and brain region-specific DNA damage response following irradiation during early neurogenesis in mice

Abstract Embryonic DNA damage resulting from DNA repair deficiencies or exposure to ionizing radiation during early neurogenesis can lead to neurodevelopmental disorders, including microcephaly. This has been linked to an excessive DNA damage response in dorsal neural progenitor cells (NPCs), result...

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Bibliographic Details
Main Authors: Lisa Berden, Nicholas Rajan, André Claude Mbouombouo Mfossa, Isabeau De Bie, Emre Etlioglu, Mohammed Abderrafi Benotmane, Mieke Verslegers, Najat Aourz, Ilse Smolders, Jean-Michel Rigo, Bert Brône, Roel Quintens
Format: Article
Language:English
Published: Springer 2025-03-01
Series:Cellular and Molecular Life Sciences
Subjects:
DNA damage
Neurodevelopment
Microcephaly
Interneuron migration
Seizures
Online Access:https://doi.org/10.1007/s00018-025-05643-7
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