A Thirty-Year Follow-Up Surveillance Study for Neoplasia of a Dutch Ulcerative Colitis Cohort
Background. Patients with ulcerative colitis have an increased risk of developing colorectal cancer (CRC). The aim of this study is to assess the yield of surveillance colonoscopies in a tertiary referral cohort of ulcerative colitis patients and to identify different risk groups for dysplasia. Meth...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2013/274715 |
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| author | J. A. M. Stolwijk A. M. J. Langers J. C. Hardwick R. A. Veenendaal H. W. Verspaget R. A. van Hogezand H. F. Vasen A. E. van der Meulen-de Jong |
| author_facet | J. A. M. Stolwijk A. M. J. Langers J. C. Hardwick R. A. Veenendaal H. W. Verspaget R. A. van Hogezand H. F. Vasen A. E. van der Meulen-de Jong |
| author_sort | J. A. M. Stolwijk |
| collection | DOAJ |
| description | Background. Patients with ulcerative colitis have an increased risk of developing colorectal cancer (CRC). The aim of this study is to assess the yield of surveillance colonoscopies in a tertiary referral cohort of ulcerative colitis patients and to identify different risk groups for dysplasia. Methods. A cohort of 293 patients (148 males, mean age 33.8 years at diagnosis) was built up at our center and started the surveillance program 8–12 years after start of symptoms. They underwent colonoscopies every one to three years. Endpoints were dysplasia or a (sub)total colectomy. Results. After a follow-up period of 10 years, the cumulative incidence of any dysplasia was 23.5%, and of CRC 4.0%. After 15 years these percentages were 33.3% and 6.8%. Patients with pancolitis (n=178) had a significantly higher cumulative risk of dysplasia than patients with distal disease, HR 1.9 (95%CI 1.1–3.3). Patients who started surveillance at an older age are at increased risk for any dysplasia, HR 1.03 (95%CI 1.01–1.05). Conclusions. This prospective surveillance study shows a high yield of dysplasia in ulcerative colitis patients. We recommend developing separate surveillance programs for different risk groups. In our opinion patients with distal colitis can follow the general population surveillance program. |
| format | Article |
| id | doaj-art-7a499afc89ca4b4ca19853eb410e1750 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-7a499afc89ca4b4ca19853eb410e17502025-02-03T05:51:56ZengWileyThe Scientific World Journal1537-744X2013-01-01201310.1155/2013/274715274715A Thirty-Year Follow-Up Surveillance Study for Neoplasia of a Dutch Ulcerative Colitis CohortJ. A. M. Stolwijk0A. M. J. Langers1J. C. Hardwick2R. A. Veenendaal3H. W. Verspaget4R. A. van Hogezand5H. F. Vasen6A. E. van der Meulen-de Jong7Gastroenterology Department, Leiden University Medical Center, Postbus 9600, 2300 RC Leiden, The NetherlandsGastroenterology Department, Leiden University Medical Center, Postbus 9600, 2300 RC Leiden, The NetherlandsGastroenterology Department, Leiden University Medical Center, Postbus 9600, 2300 RC Leiden, The NetherlandsGastroenterology Department, Leiden University Medical Center, Postbus 9600, 2300 RC Leiden, The NetherlandsGastroenterology Department, Leiden University Medical Center, Postbus 9600, 2300 RC Leiden, The NetherlandsGastroenterology Department, Leiden University Medical Center, Postbus 9600, 2300 RC Leiden, The NetherlandsGastroenterology Department, Leiden University Medical Center, Postbus 9600, 2300 RC Leiden, The NetherlandsGastroenterology Department, Leiden University Medical Center, Postbus 9600, 2300 RC Leiden, The NetherlandsBackground. Patients with ulcerative colitis have an increased risk of developing colorectal cancer (CRC). The aim of this study is to assess the yield of surveillance colonoscopies in a tertiary referral cohort of ulcerative colitis patients and to identify different risk groups for dysplasia. Methods. A cohort of 293 patients (148 males, mean age 33.8 years at diagnosis) was built up at our center and started the surveillance program 8–12 years after start of symptoms. They underwent colonoscopies every one to three years. Endpoints were dysplasia or a (sub)total colectomy. Results. After a follow-up period of 10 years, the cumulative incidence of any dysplasia was 23.5%, and of CRC 4.0%. After 15 years these percentages were 33.3% and 6.8%. Patients with pancolitis (n=178) had a significantly higher cumulative risk of dysplasia than patients with distal disease, HR 1.9 (95%CI 1.1–3.3). Patients who started surveillance at an older age are at increased risk for any dysplasia, HR 1.03 (95%CI 1.01–1.05). Conclusions. This prospective surveillance study shows a high yield of dysplasia in ulcerative colitis patients. We recommend developing separate surveillance programs for different risk groups. In our opinion patients with distal colitis can follow the general population surveillance program.http://dx.doi.org/10.1155/2013/274715 |
| spellingShingle | J. A. M. Stolwijk A. M. J. Langers J. C. Hardwick R. A. Veenendaal H. W. Verspaget R. A. van Hogezand H. F. Vasen A. E. van der Meulen-de Jong A Thirty-Year Follow-Up Surveillance Study for Neoplasia of a Dutch Ulcerative Colitis Cohort The Scientific World Journal |
| title | A Thirty-Year Follow-Up Surveillance Study for Neoplasia of a Dutch Ulcerative Colitis Cohort |
| title_full | A Thirty-Year Follow-Up Surveillance Study for Neoplasia of a Dutch Ulcerative Colitis Cohort |
| title_fullStr | A Thirty-Year Follow-Up Surveillance Study for Neoplasia of a Dutch Ulcerative Colitis Cohort |
| title_full_unstemmed | A Thirty-Year Follow-Up Surveillance Study for Neoplasia of a Dutch Ulcerative Colitis Cohort |
| title_short | A Thirty-Year Follow-Up Surveillance Study for Neoplasia of a Dutch Ulcerative Colitis Cohort |
| title_sort | thirty year follow up surveillance study for neoplasia of a dutch ulcerative colitis cohort |
| url | http://dx.doi.org/10.1155/2013/274715 |
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