Comparable Enhanced Prothrombogenesis in Simple Central Obesity and Metabolic Syndrome
Objective. There is limited data comparing prothrombogenic or fibrinolysis biomarkers (tissue plasminogen activator (tPA) and plasminogen activator inhibitor-1 (PAI-1)) simultaneously in subjects with Metabolic Syndrome (MS), simple central obesity without MS (COB) and normal controls (NC). We inves...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Obesity |
| Online Access: | http://dx.doi.org/10.1155/2018/8508549 |
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| author | Noor Shafina Mohd Nor Hanis Saimin Thuhairah Rahman Suraya Abdul Razak Nadzimah Mohd Nasir Zaliha Ismail Hapizah Mohd Nawawi |
| author_facet | Noor Shafina Mohd Nor Hanis Saimin Thuhairah Rahman Suraya Abdul Razak Nadzimah Mohd Nasir Zaliha Ismail Hapizah Mohd Nawawi |
| author_sort | Noor Shafina Mohd Nor |
| collection | DOAJ |
| description | Objective. There is limited data comparing prothrombogenic or fibrinolysis biomarkers (tissue plasminogen activator (tPA) and plasminogen activator inhibitor-1 (PAI-1)) simultaneously in subjects with Metabolic Syndrome (MS), simple central obesity without MS (COB) and normal controls (NC). We investigated the concentrations of fibrinolysis biomarkers in subjects with MS, COB and NC. Methods. A cross-sectional study involving 503 drug naive subjects (163 males, aged 30–65 years old (mean age ± SD = 47.4 ± 8.3 years)) divided into MS, COB and NC groups. COB was defined as central obesity (waist circumference (WC) males ≥90 cm, females ≥80 cm) in the absence of MS according to the International Diabetes Federation 2006. Fasting blood levels of tPA and PAI-1were analyzed. Results. MS and COB had significantly higher concentration of all biomarkers compared to NC. The MS group had significantly higher concentration of tPA and PAI-1 compared to COB. WC and HDL-c had significant correlation with all biomarkers (tPA p<0.001, PAI-1 p<0.001). Fasting plasma glucose and diastolic blood pressure were independent predictors after correcting for confounding factors. Conclusion. Central obesity with or without MS both demonstrated enhanced prothrombogenesis. This suggests that simple obesity possibly increases the risk of coronary artery disease in part, via increased susceptibility to thrombogenesis. |
| format | Article |
| id | doaj-art-7a3d55e6e8de48b6ac331068318f3ef8 |
| institution | Kabale University |
| issn | 2090-0708 2090-0716 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Obesity |
| spelling | doaj-art-7a3d55e6e8de48b6ac331068318f3ef82025-02-03T01:23:51ZengWileyJournal of Obesity2090-07082090-07162018-01-01201810.1155/2018/85085498508549Comparable Enhanced Prothrombogenesis in Simple Central Obesity and Metabolic SyndromeNoor Shafina Mohd Nor0Hanis Saimin1Thuhairah Rahman2Suraya Abdul Razak3Nadzimah Mohd Nasir4Zaliha Ismail5Hapizah Mohd Nawawi6Institute for Pathology, Laboratory and Forensic Medicine (I-PPerForM), Universiti Teknologi MARA (UiTM), 47000 Sungai Buloh, Selangor, MalaysiaFaculty of Medicine, Universiti Teknologi MARA (UiTM), 47000 Sungai Buloh, Selangor, MalaysiaFaculty of Medicine, Universiti Teknologi MARA (UiTM), 47000 Sungai Buloh, Selangor, MalaysiaInstitute for Pathology, Laboratory and Forensic Medicine (I-PPerForM), Universiti Teknologi MARA (UiTM), 47000 Sungai Buloh, Selangor, MalaysiaFaculty of Medicine, Universiti Teknologi MARA (UiTM), 47000 Sungai Buloh, Selangor, MalaysiaFaculty of Medicine, Universiti Teknologi MARA (UiTM), 47000 Sungai Buloh, Selangor, MalaysiaInstitute for Pathology, Laboratory and Forensic Medicine (I-PPerForM), Universiti Teknologi MARA (UiTM), 47000 Sungai Buloh, Selangor, MalaysiaObjective. There is limited data comparing prothrombogenic or fibrinolysis biomarkers (tissue plasminogen activator (tPA) and plasminogen activator inhibitor-1 (PAI-1)) simultaneously in subjects with Metabolic Syndrome (MS), simple central obesity without MS (COB) and normal controls (NC). We investigated the concentrations of fibrinolysis biomarkers in subjects with MS, COB and NC. Methods. A cross-sectional study involving 503 drug naive subjects (163 males, aged 30–65 years old (mean age ± SD = 47.4 ± 8.3 years)) divided into MS, COB and NC groups. COB was defined as central obesity (waist circumference (WC) males ≥90 cm, females ≥80 cm) in the absence of MS according to the International Diabetes Federation 2006. Fasting blood levels of tPA and PAI-1were analyzed. Results. MS and COB had significantly higher concentration of all biomarkers compared to NC. The MS group had significantly higher concentration of tPA and PAI-1 compared to COB. WC and HDL-c had significant correlation with all biomarkers (tPA p<0.001, PAI-1 p<0.001). Fasting plasma glucose and diastolic blood pressure were independent predictors after correcting for confounding factors. Conclusion. Central obesity with or without MS both demonstrated enhanced prothrombogenesis. This suggests that simple obesity possibly increases the risk of coronary artery disease in part, via increased susceptibility to thrombogenesis.http://dx.doi.org/10.1155/2018/8508549 |
| spellingShingle | Noor Shafina Mohd Nor Hanis Saimin Thuhairah Rahman Suraya Abdul Razak Nadzimah Mohd Nasir Zaliha Ismail Hapizah Mohd Nawawi Comparable Enhanced Prothrombogenesis in Simple Central Obesity and Metabolic Syndrome Journal of Obesity |
| title | Comparable Enhanced Prothrombogenesis in Simple Central Obesity and Metabolic Syndrome |
| title_full | Comparable Enhanced Prothrombogenesis in Simple Central Obesity and Metabolic Syndrome |
| title_fullStr | Comparable Enhanced Prothrombogenesis in Simple Central Obesity and Metabolic Syndrome |
| title_full_unstemmed | Comparable Enhanced Prothrombogenesis in Simple Central Obesity and Metabolic Syndrome |
| title_short | Comparable Enhanced Prothrombogenesis in Simple Central Obesity and Metabolic Syndrome |
| title_sort | comparable enhanced prothrombogenesis in simple central obesity and metabolic syndrome |
| url | http://dx.doi.org/10.1155/2018/8508549 |
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