Endurance Exercise Mobilizes Developmentally Early Stem Cells into Peripheral Blood and Increases Their Number in Bone Marrow: Implications for Tissue Regeneration
Endurance exercise has been reported to increase the number of circulating hematopoietic stem/progenitor cells (HSPCs) in peripheral blood (PB) as well as in bone marrow (BM). We therefore became interested in whether endurance exercise has the same effect on very small embryonic-like stem cells (VS...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2016/5756901 |
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| author | Krzysztof Marycz Katarzyna Mierzejewska Agnieszka Śmieszek Ewa Suszynska Iwona Malicka Magda Kucia Mariusz Z. Ratajczak |
| author_facet | Krzysztof Marycz Katarzyna Mierzejewska Agnieszka Śmieszek Ewa Suszynska Iwona Malicka Magda Kucia Mariusz Z. Ratajczak |
| author_sort | Krzysztof Marycz |
| collection | DOAJ |
| description | Endurance exercise has been reported to increase the number of circulating hematopoietic stem/progenitor cells (HSPCs) in peripheral blood (PB) as well as in bone marrow (BM). We therefore became interested in whether endurance exercise has the same effect on very small embryonic-like stem cells (VSELs), which have been described as a population of developmentally early stem cells residing in BM. Mice were run daily for 1 hour on a treadmill for periods of 5 days or 5 weeks. Human volunteers had trained in long-distance running for one year, six times per week. FACS-based analyses and RT-PCR of murine and human VSELs and HSPCs from collected bone marrow and peripheral blood were performed. We observed that endurance exercise increased the number of VSELs circulating in PB and residing in BM. In parallel, we observed an increase in the number of HSPCs. These observations were subsequently confirmed in young athletes, who showed an increase in circulating VSELs and HSPCs after intensive running exercise. We provide for the first time evidence that endurance exercise may have beneficial effects on the expansion of developmentally early stem cells. We hypothesize that these circulating stem cells are involved in repairing minor exercise-related tissue and organ injuries. |
| format | Article |
| id | doaj-art-7a3c9f0765c248b79acad18aac301279 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-7a3c9f0765c248b79acad18aac3012792025-02-03T06:11:29ZengWileyStem Cells International1687-966X1687-96782016-01-01201610.1155/2016/57569015756901Endurance Exercise Mobilizes Developmentally Early Stem Cells into Peripheral Blood and Increases Their Number in Bone Marrow: Implications for Tissue RegenerationKrzysztof Marycz0Katarzyna Mierzejewska1Agnieszka Śmieszek2Ewa Suszynska3Iwona Malicka4Magda Kucia5Mariusz Z. Ratajczak6Faculty of Biology, University of Environmental and Life Sciences, 50-375 Wroclaw, PolandDepartment of Regenerative Medicine, Medical University of Warsaw, 02-091 Warsaw, PolandFaculty of Biology, University of Environmental and Life Sciences, 50-375 Wroclaw, PolandDepartment of Regenerative Medicine, Medical University of Warsaw, 02-091 Warsaw, PolandDepartment of Physiotherapy, University School of Physical Education, 51-617 Wroclaw, PolandDepartment of Regenerative Medicine, Medical University of Warsaw, 02-091 Warsaw, PolandDepartment of Regenerative Medicine, Medical University of Warsaw, 02-091 Warsaw, PolandEndurance exercise has been reported to increase the number of circulating hematopoietic stem/progenitor cells (HSPCs) in peripheral blood (PB) as well as in bone marrow (BM). We therefore became interested in whether endurance exercise has the same effect on very small embryonic-like stem cells (VSELs), which have been described as a population of developmentally early stem cells residing in BM. Mice were run daily for 1 hour on a treadmill for periods of 5 days or 5 weeks. Human volunteers had trained in long-distance running for one year, six times per week. FACS-based analyses and RT-PCR of murine and human VSELs and HSPCs from collected bone marrow and peripheral blood were performed. We observed that endurance exercise increased the number of VSELs circulating in PB and residing in BM. In parallel, we observed an increase in the number of HSPCs. These observations were subsequently confirmed in young athletes, who showed an increase in circulating VSELs and HSPCs after intensive running exercise. We provide for the first time evidence that endurance exercise may have beneficial effects on the expansion of developmentally early stem cells. We hypothesize that these circulating stem cells are involved in repairing minor exercise-related tissue and organ injuries.http://dx.doi.org/10.1155/2016/5756901 |
| spellingShingle | Krzysztof Marycz Katarzyna Mierzejewska Agnieszka Śmieszek Ewa Suszynska Iwona Malicka Magda Kucia Mariusz Z. Ratajczak Endurance Exercise Mobilizes Developmentally Early Stem Cells into Peripheral Blood and Increases Their Number in Bone Marrow: Implications for Tissue Regeneration Stem Cells International |
| title | Endurance Exercise Mobilizes Developmentally Early Stem Cells into Peripheral Blood and Increases Their Number in Bone Marrow: Implications for Tissue Regeneration |
| title_full | Endurance Exercise Mobilizes Developmentally Early Stem Cells into Peripheral Blood and Increases Their Number in Bone Marrow: Implications for Tissue Regeneration |
| title_fullStr | Endurance Exercise Mobilizes Developmentally Early Stem Cells into Peripheral Blood and Increases Their Number in Bone Marrow: Implications for Tissue Regeneration |
| title_full_unstemmed | Endurance Exercise Mobilizes Developmentally Early Stem Cells into Peripheral Blood and Increases Their Number in Bone Marrow: Implications for Tissue Regeneration |
| title_short | Endurance Exercise Mobilizes Developmentally Early Stem Cells into Peripheral Blood and Increases Their Number in Bone Marrow: Implications for Tissue Regeneration |
| title_sort | endurance exercise mobilizes developmentally early stem cells into peripheral blood and increases their number in bone marrow implications for tissue regeneration |
| url | http://dx.doi.org/10.1155/2016/5756901 |
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