Hepatitis E virus infection among blood donors in Zhengzhou
[Objective] To analyze the infection status of hepatitis E virus (HEV) among blood donors in Zhengzhou, so as to provide data support for formulating local blood screening strategies. [Methods] Random samples from blood donors from January to December 2022 were tested for HEV RNA using PCR technolog...
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Institute of Blood Transfusion of Chinese Academy of Medical Sciences
2025-01-01
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| Series: | Zhongguo shuxue zazhi |
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| Online Access: | https://www.cjbt.cn/thesisDetails#10.13303/j.cjbt.issn.1004-549x.2025.01.003&lang=en |
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| _version_ | 1832585136054468608 |
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| author | ZHAO Hongna WEI Yueguang YAN Lumin TU Tiantian WANG Shumin WEI Yihui WANG Yifang ZHAO Lei CHEN Mingjun |
| author_facet | ZHAO Hongna WEI Yueguang YAN Lumin TU Tiantian WANG Shumin WEI Yihui WANG Yifang ZHAO Lei CHEN Mingjun |
| author_sort | ZHAO Hongna |
| collection | DOAJ |
| description | [Objective] To analyze the infection status of hepatitis E virus (HEV) among blood donors in Zhengzhou, so as to provide data support for formulating local blood screening strategies. [Methods] Random samples from blood donors from January to December 2022 were tested for HEV RNA using PCR technology. Reactive samples were sequenced for gene analysis, and the donors were followed up. [Results] Among 21 311 samples, 3(0.14‰) were reactive for HEV RNA, all of whom were male. Genetic sequencing results revealed that one strong positive sample was genotype 4, while sequencing failed for the other two due to low viral load. A follow-up of 25 strong positive donors showed that ALT significantly increased on day 7 after donation, anti-HEV IgM and anti-HEV IgG turned positive. On day 21, ALT returned to normal, and on day 35, HEV RNA turned negative. Notably, anti-HEV IgM and anti-HEV IgG persisted until day 482. [Conclusion] There is HEV infection among blood donors in Zhengzhou, and it is necessary to expand the screening scope to comprehensively explore the prevalence and genotype distribution of HEV among blood donors. |
| format | Article |
| id | doaj-art-7a395f53a685446dbcdbf7d51c6a7123 |
| institution | Kabale University |
| issn | 1004-549X |
| language | zho |
| publishDate | 2025-01-01 |
| publisher | Institute of Blood Transfusion of Chinese Academy of Medical Sciences |
| record_format | Article |
| series | Zhongguo shuxue zazhi |
| spelling | doaj-art-7a395f53a685446dbcdbf7d51c6a71232025-01-27T01:46:11ZzhoInstitute of Blood Transfusion of Chinese Academy of Medical SciencesZhongguo shuxue zazhi1004-549X2025-01-01381131810.13303/j.cjbt.issn.1004-549x.2025.01.0031004-549X(2025)1-0013-06Hepatitis E virus infection among blood donors in ZhengzhouZHAO Hongna0WEI Yueguang1YAN Lumin2TU Tiantian3WANG Shumin4WEI Yihui5WANG Yifang6ZHAO Lei7CHEN Mingjun8Henan Red Cross Blood Center, Henan Blood Safety Research Institute, Zhengzhou 450000, ChinaHenan Red Cross Blood Center, Henan Blood Safety Research Institute, Zhengzhou 450000, ChinaHenan Red Cross Blood Center, Henan Blood Safety Research Institute, Zhengzhou 450000, ChinaHenan Red Cross Blood Center, Henan Blood Safety Research Institute, Zhengzhou 450000, ChinaHenan Red Cross Blood Center, Henan Blood Safety Research Institute, Zhengzhou 450000, ChinaHenan Red Cross Blood Center, Henan Blood Safety Research Institute, Zhengzhou 450000, ChinaHenan Red Cross Blood Center, Henan Blood Safety Research Institute, Zhengzhou 450000, ChinaHenan Red Cross Blood Center, Henan Blood Safety Research Institute, Zhengzhou 450000, ChinaHenan Red Cross Blood Center, Henan Blood Safety Research Institute, Zhengzhou 450000, China[Objective] To analyze the infection status of hepatitis E virus (HEV) among blood donors in Zhengzhou, so as to provide data support for formulating local blood screening strategies. [Methods] Random samples from blood donors from January to December 2022 were tested for HEV RNA using PCR technology. Reactive samples were sequenced for gene analysis, and the donors were followed up. [Results] Among 21 311 samples, 3(0.14‰) were reactive for HEV RNA, all of whom were male. Genetic sequencing results revealed that one strong positive sample was genotype 4, while sequencing failed for the other two due to low viral load. A follow-up of 25 strong positive donors showed that ALT significantly increased on day 7 after donation, anti-HEV IgM and anti-HEV IgG turned positive. On day 21, ALT returned to normal, and on day 35, HEV RNA turned negative. Notably, anti-HEV IgM and anti-HEV IgG persisted until day 482. [Conclusion] There is HEV infection among blood donors in Zhengzhou, and it is necessary to expand the screening scope to comprehensively explore the prevalence and genotype distribution of HEV among blood donors.https://www.cjbt.cn/thesisDetails#10.13303/j.cjbt.issn.1004-549x.2025.01.003&lang=enblood donorshepatitis e virusnucleic acid testinggenotypefollow-up |
| spellingShingle | ZHAO Hongna WEI Yueguang YAN Lumin TU Tiantian WANG Shumin WEI Yihui WANG Yifang ZHAO Lei CHEN Mingjun Hepatitis E virus infection among blood donors in Zhengzhou Zhongguo shuxue zazhi blood donors hepatitis e virus nucleic acid testing genotype follow-up |
| title | Hepatitis E virus infection among blood donors in Zhengzhou |
| title_full | Hepatitis E virus infection among blood donors in Zhengzhou |
| title_fullStr | Hepatitis E virus infection among blood donors in Zhengzhou |
| title_full_unstemmed | Hepatitis E virus infection among blood donors in Zhengzhou |
| title_short | Hepatitis E virus infection among blood donors in Zhengzhou |
| title_sort | hepatitis e virus infection among blood donors in zhengzhou |
| topic | blood donors hepatitis e virus nucleic acid testing genotype follow-up |
| url | https://www.cjbt.cn/thesisDetails#10.13303/j.cjbt.issn.1004-549x.2025.01.003&lang=en |
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