Diacerein Inhibits Myopia Progression through Lowering Inflammation in Retinal Pigment Epithelial Cell
Myopia is a highly prevalent refractive disorder. We investigated the effect of diacerein on monocular form deprivation (MFD) in hamsters as a possible therapeutic intervention. Diacerein is an anthraquinone derivative drug whose active metabolite is rhein. Diacerein or atropine was applied to the M...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2021/6660640 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832546204528934912 |
|---|---|
| author | Peng-Tai Tien Chia-Hung Lin Chih-Sheng Chen Ching-Yao Chang Hsiangyu Ku Dekang Gan Yi-Yu Tsai Jamie Jiin-Yi Chen Hui-Ju Lin Lei Wan |
| author_facet | Peng-Tai Tien Chia-Hung Lin Chih-Sheng Chen Ching-Yao Chang Hsiangyu Ku Dekang Gan Yi-Yu Tsai Jamie Jiin-Yi Chen Hui-Ju Lin Lei Wan |
| author_sort | Peng-Tai Tien |
| collection | DOAJ |
| description | Myopia is a highly prevalent refractive disorder. We investigated the effect of diacerein on monocular form deprivation (MFD) in hamsters as a possible therapeutic intervention. Diacerein is an anthraquinone derivative drug whose active metabolite is rhein. Diacerein or atropine was applied to the MFD hamsters, and their refractive error and axial length were measured after 21 days. The refractive error (control: −0.91±0.023, atropine: −0.3±0.08, and diacerein: −0.27±0.07 D) and axial length (control: 0.401±0.017, atropine: 0.326±0.017, and diacerein: 0.334±0.016 mm) showed statistically significant differences between control, atropine-treated, and diacerein-treated MFD eyes. Furthermore, we determined the level of transforming growth factor-beta- (TGF-) β1, matrix metalloproteinase- (MMP-) 2, type I collagen, interleukin- (IL-) 6, IL-8, and monocyte chemoattractant protein- (MCP-) 1 in the retina. Atropine and diacerein suppressed levels of the myopia-related TGF-β1 and MMP-2 while increasing type I collagen expression. They also inhibited the interleukin IL-6, IL-8, and MCP-1 levels. Diacerein reduced the IL-6, IL-8, and MCP-1 expression in ARPE-19 cells. Furthermore, diacerein inhibited inflammation by attenuating the phosphorylation of protein kinase B (AKT) and nuclear factor kappa-light-chain-enhancer of activated B (NF-κB) pathway. This suggests that diacerein has a therapeutic effect on myopia and is a potential treatment option. |
| format | Article |
| id | doaj-art-7a385fb8620d4ab49fb3698a170f357f |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-7a385fb8620d4ab49fb3698a170f357f2025-02-03T07:23:31ZengWileyMediators of Inflammation0962-93511466-18612021-01-01202110.1155/2021/66606406660640Diacerein Inhibits Myopia Progression through Lowering Inflammation in Retinal Pigment Epithelial CellPeng-Tai Tien0Chia-Hung Lin1Chih-Sheng Chen2Ching-Yao Chang3Hsiangyu Ku4Dekang Gan5Yi-Yu Tsai6Jamie Jiin-Yi Chen7Hui-Ju Lin8Lei Wan9Graduate Institute of Clinical Medical Science, College of Medicine, China Medical University, Taichung, TaiwanSchool of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung, TaiwanSchool of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung, TaiwanDepartment of Medical Laboratory Science and Biotechnology, Asia University, Taichung, TaiwanDepartment of Ophthalmology and Visual Science, Eye and ENT Hospital, Shanghai Medical College, Fudan University, Shanghai 200031, ChinaDepartment of Ophthalmology and Visual Science, Eye and ENT Hospital, Shanghai Medical College, Fudan University, Shanghai 200031, ChinaGraduate Institute of Clinical Medical Science, College of Medicine, China Medical University, Taichung, TaiwanDepartment of Ophthalmology, China Medical University Hospital, Taichung, TaiwanDepartment of Ophthalmology, China Medical University Hospital, Taichung, TaiwanSchool of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung, TaiwanMyopia is a highly prevalent refractive disorder. We investigated the effect of diacerein on monocular form deprivation (MFD) in hamsters as a possible therapeutic intervention. Diacerein is an anthraquinone derivative drug whose active metabolite is rhein. Diacerein or atropine was applied to the MFD hamsters, and their refractive error and axial length were measured after 21 days. The refractive error (control: −0.91±0.023, atropine: −0.3±0.08, and diacerein: −0.27±0.07 D) and axial length (control: 0.401±0.017, atropine: 0.326±0.017, and diacerein: 0.334±0.016 mm) showed statistically significant differences between control, atropine-treated, and diacerein-treated MFD eyes. Furthermore, we determined the level of transforming growth factor-beta- (TGF-) β1, matrix metalloproteinase- (MMP-) 2, type I collagen, interleukin- (IL-) 6, IL-8, and monocyte chemoattractant protein- (MCP-) 1 in the retina. Atropine and diacerein suppressed levels of the myopia-related TGF-β1 and MMP-2 while increasing type I collagen expression. They also inhibited the interleukin IL-6, IL-8, and MCP-1 levels. Diacerein reduced the IL-6, IL-8, and MCP-1 expression in ARPE-19 cells. Furthermore, diacerein inhibited inflammation by attenuating the phosphorylation of protein kinase B (AKT) and nuclear factor kappa-light-chain-enhancer of activated B (NF-κB) pathway. This suggests that diacerein has a therapeutic effect on myopia and is a potential treatment option.http://dx.doi.org/10.1155/2021/6660640 |
| spellingShingle | Peng-Tai Tien Chia-Hung Lin Chih-Sheng Chen Ching-Yao Chang Hsiangyu Ku Dekang Gan Yi-Yu Tsai Jamie Jiin-Yi Chen Hui-Ju Lin Lei Wan Diacerein Inhibits Myopia Progression through Lowering Inflammation in Retinal Pigment Epithelial Cell Mediators of Inflammation |
| title | Diacerein Inhibits Myopia Progression through Lowering Inflammation in Retinal Pigment Epithelial Cell |
| title_full | Diacerein Inhibits Myopia Progression through Lowering Inflammation in Retinal Pigment Epithelial Cell |
| title_fullStr | Diacerein Inhibits Myopia Progression through Lowering Inflammation in Retinal Pigment Epithelial Cell |
| title_full_unstemmed | Diacerein Inhibits Myopia Progression through Lowering Inflammation in Retinal Pigment Epithelial Cell |
| title_short | Diacerein Inhibits Myopia Progression through Lowering Inflammation in Retinal Pigment Epithelial Cell |
| title_sort | diacerein inhibits myopia progression through lowering inflammation in retinal pigment epithelial cell |
| url | http://dx.doi.org/10.1155/2021/6660640 |
| work_keys_str_mv | AT pengtaitien diacereininhibitsmyopiaprogressionthroughloweringinflammationinretinalpigmentepithelialcell AT chiahunglin diacereininhibitsmyopiaprogressionthroughloweringinflammationinretinalpigmentepithelialcell AT chihshengchen diacereininhibitsmyopiaprogressionthroughloweringinflammationinretinalpigmentepithelialcell AT chingyaochang diacereininhibitsmyopiaprogressionthroughloweringinflammationinretinalpigmentepithelialcell AT hsiangyuku diacereininhibitsmyopiaprogressionthroughloweringinflammationinretinalpigmentepithelialcell AT dekanggan diacereininhibitsmyopiaprogressionthroughloweringinflammationinretinalpigmentepithelialcell AT yiyutsai diacereininhibitsmyopiaprogressionthroughloweringinflammationinretinalpigmentepithelialcell AT jamiejiinyichen diacereininhibitsmyopiaprogressionthroughloweringinflammationinretinalpigmentepithelialcell AT huijulin diacereininhibitsmyopiaprogressionthroughloweringinflammationinretinalpigmentepithelialcell AT leiwan diacereininhibitsmyopiaprogressionthroughloweringinflammationinretinalpigmentepithelialcell |