A decade with anomic primary progressive aphasia
Some patients with primary progressive aphasia (PPA) demonstrate only anomia. The lack of longitudinal observations of anomic PPA precluded us from determining whether progressive anomic aphasia was simply an early stage of semantic or logopenic variants, or a relatively independent variant. Herein,...
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Elsevier
2024-06-01
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| Series: | eNeurologicalSci |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405650224000157 |
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| author | Shoko Ota Kazuo Kakinuma Wataru Narita Yoshiyuki Nishio Nobuko Kawakami Ayane Tamagake Shigenori Kanno Minoru Matsuda Kyoko Suzuki |
| author_facet | Shoko Ota Kazuo Kakinuma Wataru Narita Yoshiyuki Nishio Nobuko Kawakami Ayane Tamagake Shigenori Kanno Minoru Matsuda Kyoko Suzuki |
| author_sort | Shoko Ota |
| collection | DOAJ |
| description | Some patients with primary progressive aphasia (PPA) demonstrate only anomia. The lack of longitudinal observations of anomic PPA precluded us from determining whether progressive anomic aphasia was simply an early stage of semantic or logopenic variants, or a relatively independent variant. Herein, we report the 10-year clinical course of a patient with PPA who presented with pure anomic aphasia for 9 years. He is a right-handed man with anomia, who noticed word-finding difficulty at age 73. He was admitted to the hospital at age 77. On admission, the patient showed pure anomic aphasia with preserved other language function. Episodic memory and visuospatial function were preserved. Magnetic resonance imaging (MRI) revealed left temporal lobe atrophy. At 82 years of age, the patient presented with pure anomic aphasia. At 83 years old, he showed mild impairment in word comprehension and semantic memory, in addition to anomia. MRI demonstrated further atrophy in the bilateral anterior temporal lobes, predominantly on the left side. This case suggests the possibility of slowly progressive, late-onset anomic PPA, which could be differentiated from the early stage of semantic or logopenic variants. |
| format | Article |
| id | doaj-art-7a24eaa593fd4f30a34b24a7b92fcab8 |
| institution | OA Journals |
| issn | 2405-6502 |
| language | English |
| publishDate | 2024-06-01 |
| publisher | Elsevier |
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| series | eNeurologicalSci |
| spelling | doaj-art-7a24eaa593fd4f30a34b24a7b92fcab82025-08-20T02:05:51ZengElseviereNeurologicalSci2405-65022024-06-013510050810.1016/j.ensci.2024.100508A decade with anomic primary progressive aphasiaShoko Ota0Kazuo Kakinuma1Wataru Narita2Yoshiyuki Nishio3Nobuko Kawakami4Ayane Tamagake5Shigenori Kanno6Minoru Matsuda7Kyoko Suzuki8Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, Sendai, Japan; Corresponding author at: Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, 2-1, Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8575, Japan.Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, Sendai, JapanSendai Rehabilitation Hospital, Tomiya, JapanDepartment of Behavioral Neurology and Neuropsychiatry, Osaka University United Graduate School of Child Development, Suita, JapanDepartment of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, Sendai, JapanDepartment of Neurology, Tohoku University Graduate School of Medicine, Sendai, JapanDepartment of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, Sendai, JapanSeizankai Group, Izuminomori Clinic, Sendai, JapanDepartment of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, Sendai, JapanSome patients with primary progressive aphasia (PPA) demonstrate only anomia. The lack of longitudinal observations of anomic PPA precluded us from determining whether progressive anomic aphasia was simply an early stage of semantic or logopenic variants, or a relatively independent variant. Herein, we report the 10-year clinical course of a patient with PPA who presented with pure anomic aphasia for 9 years. He is a right-handed man with anomia, who noticed word-finding difficulty at age 73. He was admitted to the hospital at age 77. On admission, the patient showed pure anomic aphasia with preserved other language function. Episodic memory and visuospatial function were preserved. Magnetic resonance imaging (MRI) revealed left temporal lobe atrophy. At 82 years of age, the patient presented with pure anomic aphasia. At 83 years old, he showed mild impairment in word comprehension and semantic memory, in addition to anomia. MRI demonstrated further atrophy in the bilateral anterior temporal lobes, predominantly on the left side. This case suggests the possibility of slowly progressive, late-onset anomic PPA, which could be differentiated from the early stage of semantic or logopenic variants.http://www.sciencedirect.com/science/article/pii/S2405650224000157Primary progressive aphasiaAnomic aphasiaLate-onsetClinical course |
| spellingShingle | Shoko Ota Kazuo Kakinuma Wataru Narita Yoshiyuki Nishio Nobuko Kawakami Ayane Tamagake Shigenori Kanno Minoru Matsuda Kyoko Suzuki A decade with anomic primary progressive aphasia eNeurologicalSci Primary progressive aphasia Anomic aphasia Late-onset Clinical course |
| title | A decade with anomic primary progressive aphasia |
| title_full | A decade with anomic primary progressive aphasia |
| title_fullStr | A decade with anomic primary progressive aphasia |
| title_full_unstemmed | A decade with anomic primary progressive aphasia |
| title_short | A decade with anomic primary progressive aphasia |
| title_sort | decade with anomic primary progressive aphasia |
| topic | Primary progressive aphasia Anomic aphasia Late-onset Clinical course |
| url | http://www.sciencedirect.com/science/article/pii/S2405650224000157 |
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