Exploring skin aging-associated genotypes; Moving toward delivery of precision medicine-based care more than beyond skin deep care: a genome-wide association study
Abstract Background Oxidative damage is the principal cellular disturbance in the skin aging. Missense polymorphisms strengthen or weaken detoxification enzyme activity. Determination of deleterious functional effects of polymorphisms in detoxification genes (NQO1 and EPHX1) in skin aging was the ov...
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BMC
2025-05-01
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| Series: | BMC Geriatrics |
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| Online Access: | https://doi.org/10.1186/s12877-025-05978-7 |
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| author | Sam Nowroozi Khalil Khashei Varnamkhasti Samire Khashei Varnamkhasti Leila Naeimi Behrouz Naeimi Sirous Naeimi |
| author_facet | Sam Nowroozi Khalil Khashei Varnamkhasti Samire Khashei Varnamkhasti Leila Naeimi Behrouz Naeimi Sirous Naeimi |
| author_sort | Sam Nowroozi |
| collection | DOAJ |
| description | Abstract Background Oxidative damage is the principal cellular disturbance in the skin aging. Missense polymorphisms strengthen or weaken detoxification enzyme activity. Determination of deleterious functional effects of polymorphisms in detoxification genes (NQO1 and EPHX1) in skin aging was the overall purpose of conducting this hospital-based research. Methods Cases recruitment on dermatological examination-based evidence performed sequentially between November 2022, and April 2023 at the Motahari Hospital Dermatology Outpatient Clinic. Genotype analysis was performed using PCR–RFLP and T-ARMS -PCR. All statistical analyses were performed using SPSS software, and differences were taken as significant at P < 0.05. Results This study results implicate that skin aging obtains on a genetic level and in particular the results suggest that His139Arg, Tyr113His and P187S represent true genetic susceptible loci for cutaneous aging related traits. We found that these new susceptibility loci exhibit sex- and age-specific effect on aging skin risk as well as implicated in interactions with modifiable risk factors including water intake, micronutrient care, sleeping habits, sun exposure and application of sunscreen cream, in the development of an increased risk of aging skin. Conclusions Molecular defects associated with the His139Arg, Tyr113His and P187S polymorphisms manifest as an observable change in the external appearance of the skin. This study underscores the need to move toward scrutinizing the ageing skin changes at molecular levels. |
| format | Article |
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| institution | OA Journals |
| issn | 1471-2318 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | BMC |
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| series | BMC Geriatrics |
| spelling | doaj-art-7a10bf8d219c4f2da2f4fe1cb4e8faaa2025-08-20T02:10:50ZengBMCBMC Geriatrics1471-23182025-05-0125111210.1186/s12877-025-05978-7Exploring skin aging-associated genotypes; Moving toward delivery of precision medicine-based care more than beyond skin deep care: a genome-wide association studySam Nowroozi0Khalil Khashei Varnamkhasti1Samire Khashei Varnamkhasti2Leila Naeimi3Behrouz Naeimi4Sirous Naeimi5Department of Genetics, College of Science, Kazerun Branch, Islamic Azad UniversityDepartment of Medical Laboratory Sciences, Faculty of Medicine, Kazerun Branch, Islamic Azad UniversityDepartment of Medical Laboratory Sciences, Faculty of Medicine, Kazerun Branch, Islamic Azad UniversityDepartment of Genetics, College of Science, Kazerun Branch, Islamic Azad UniversityDepartment of Medical Laboratory Sciences, Faculty of Paramedical, Bushehr University of Medical SciencesDepartment of Biology, Zand Institute of Higher EducationAbstract Background Oxidative damage is the principal cellular disturbance in the skin aging. Missense polymorphisms strengthen or weaken detoxification enzyme activity. Determination of deleterious functional effects of polymorphisms in detoxification genes (NQO1 and EPHX1) in skin aging was the overall purpose of conducting this hospital-based research. Methods Cases recruitment on dermatological examination-based evidence performed sequentially between November 2022, and April 2023 at the Motahari Hospital Dermatology Outpatient Clinic. Genotype analysis was performed using PCR–RFLP and T-ARMS -PCR. All statistical analyses were performed using SPSS software, and differences were taken as significant at P < 0.05. Results This study results implicate that skin aging obtains on a genetic level and in particular the results suggest that His139Arg, Tyr113His and P187S represent true genetic susceptible loci for cutaneous aging related traits. We found that these new susceptibility loci exhibit sex- and age-specific effect on aging skin risk as well as implicated in interactions with modifiable risk factors including water intake, micronutrient care, sleeping habits, sun exposure and application of sunscreen cream, in the development of an increased risk of aging skin. Conclusions Molecular defects associated with the His139Arg, Tyr113His and P187S polymorphisms manifest as an observable change in the external appearance of the skin. This study underscores the need to move toward scrutinizing the ageing skin changes at molecular levels.https://doi.org/10.1186/s12877-025-05978-7Aging SkinGeriatric SkinPolymorphismHis139 ArgTyr113HisP187S |
| spellingShingle | Sam Nowroozi Khalil Khashei Varnamkhasti Samire Khashei Varnamkhasti Leila Naeimi Behrouz Naeimi Sirous Naeimi Exploring skin aging-associated genotypes; Moving toward delivery of precision medicine-based care more than beyond skin deep care: a genome-wide association study BMC Geriatrics Aging Skin Geriatric Skin Polymorphism His139 Arg Tyr113His P187S |
| title | Exploring skin aging-associated genotypes; Moving toward delivery of precision medicine-based care more than beyond skin deep care: a genome-wide association study |
| title_full | Exploring skin aging-associated genotypes; Moving toward delivery of precision medicine-based care more than beyond skin deep care: a genome-wide association study |
| title_fullStr | Exploring skin aging-associated genotypes; Moving toward delivery of precision medicine-based care more than beyond skin deep care: a genome-wide association study |
| title_full_unstemmed | Exploring skin aging-associated genotypes; Moving toward delivery of precision medicine-based care more than beyond skin deep care: a genome-wide association study |
| title_short | Exploring skin aging-associated genotypes; Moving toward delivery of precision medicine-based care more than beyond skin deep care: a genome-wide association study |
| title_sort | exploring skin aging associated genotypes moving toward delivery of precision medicine based care more than beyond skin deep care a genome wide association study |
| topic | Aging Skin Geriatric Skin Polymorphism His139 Arg Tyr113His P187S |
| url | https://doi.org/10.1186/s12877-025-05978-7 |
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