Prognostic and Risk Factors in Patients with Locally Advanced Cutaneous Squamous Cell Carcinoma of the Trunk and Extremities
55 patients with advanced cutaneous squamous cell carcinoma (CSCC) of the trunk and extremities were studied. A Tissue Microarray was constructed using immunohistochemistry to quantify expression of the HER family, E-cadherins, and podoplanin. Clinical and histopathological factors related to lymph...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Journal of Skin Cancer |
| Online Access: | http://dx.doi.org/10.1155/2011/420796 |
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| author | de Lima Vazquez Vinicius Cristovam Scapulatempo Natalia Martins Perpetuo Faheez Mohamed Teóclito Sachetto de Carvalho Antônio Talvane Torres de Oliveira José Getúlio Martins Segalla André Lopes Carvalho |
| author_facet | de Lima Vazquez Vinicius Cristovam Scapulatempo Natalia Martins Perpetuo Faheez Mohamed Teóclito Sachetto de Carvalho Antônio Talvane Torres de Oliveira José Getúlio Martins Segalla André Lopes Carvalho |
| author_sort | de Lima Vazquez Vinicius |
| collection | DOAJ |
| description | 55 patients with advanced cutaneous squamous cell carcinoma (CSCC) of the trunk and extremities were studied. A Tissue Microarray was constructed using immunohistochemistry to quantify expression of the HER family, E-cadherins, and podoplanin. Clinical and histopathological factors related to lymph node metastasis and prognosis were also established. Primary tumor positivity was 25.5% for EGFR, 87.3% for HER-3, and 48.1% for HER-4. Metastases were positive for EGFR in 41.7%, for HER-3 in 83.3%, and HER-4 in 43.5%. HER-2 was negative in all samples. Membrane E-cadherin and cytoplasmic E-cadherin were positive in 47.3% and 30.2% of primary tumors and 45.5% and 27.3% of metastases, respectively. Podoplanin was positive in 41.8% of primary tumors and 41.7% of metastases. Intratumoral lymphocytic infiltrate was associated with lymph node metastasis. Patients with T3 tumors had better cancer-specific survival (CSS) than those with T4 tumors; patients with no lymph node involvement had better CSS than patients with N1 tumors. Undifferentiated tumors and hyperexpression of podoplanin were negative prognostic indicators on multivariate analysis. |
| format | Article |
| id | doaj-art-7a061a4b2d1249cfb26c0c2f81986344 |
| institution | Kabale University |
| issn | 2090-2905 2090-2913 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Skin Cancer |
| spelling | doaj-art-7a061a4b2d1249cfb26c0c2f819863442025-02-03T01:09:48ZengWileyJournal of Skin Cancer2090-29052090-29132011-01-01201110.1155/2011/420796420796Prognostic and Risk Factors in Patients with Locally Advanced Cutaneous Squamous Cell Carcinoma of the Trunk and Extremitiesde Lima Vazquez Vinicius0Cristovam Scapulatempo1Natalia Martins Perpetuo2Faheez Mohamed3Teóclito Sachetto de Carvalho4Antônio Talvane Torres de Oliveira5José Getúlio Martins Segalla6André Lopes Carvalho7Department of Surgery and Pathology, Hospital de Câncer de Barretos, Rua Antenor Duarte Villela, 1331-Bairro Paulo Prata, 14784-400 Barretos, SP, BrazilDepartment of Surgery and Pathology, Hospital de Câncer de Barretos, Rua Antenor Duarte Villela, 1331-Bairro Paulo Prata, 14784-400 Barretos, SP, BrazilDepartment of Surgery and Pathology, Hospital de Câncer de Barretos, Rua Antenor Duarte Villela, 1331-Bairro Paulo Prata, 14784-400 Barretos, SP, BrazilDivision of Surgery, Basingstoke and North Hampshire NHS Foundation Trust, ldermaston Road Basingstoke, Hampshire RG24 9NA, UKDepartment of Surgery and Pathology, Hospital de Câncer de Barretos, Rua Antenor Duarte Villela, 1331-Bairro Paulo Prata, 14784-400 Barretos, SP, BrazilDepartment of Surgery and Pathology, Hospital de Câncer de Barretos, Rua Antenor Duarte Villela, 1331-Bairro Paulo Prata, 14784-400 Barretos, SP, BrazilDepartment of Clinical Oncology, Hospital Amaral Carvalho, R Dona Silveria, 150 17203-570 Jaú SP, BrazilDepartment of Surgery and Pathology, Hospital de Câncer de Barretos, Rua Antenor Duarte Villela, 1331-Bairro Paulo Prata, 14784-400 Barretos, SP, Brazil55 patients with advanced cutaneous squamous cell carcinoma (CSCC) of the trunk and extremities were studied. A Tissue Microarray was constructed using immunohistochemistry to quantify expression of the HER family, E-cadherins, and podoplanin. Clinical and histopathological factors related to lymph node metastasis and prognosis were also established. Primary tumor positivity was 25.5% for EGFR, 87.3% for HER-3, and 48.1% for HER-4. Metastases were positive for EGFR in 41.7%, for HER-3 in 83.3%, and HER-4 in 43.5%. HER-2 was negative in all samples. Membrane E-cadherin and cytoplasmic E-cadherin were positive in 47.3% and 30.2% of primary tumors and 45.5% and 27.3% of metastases, respectively. Podoplanin was positive in 41.8% of primary tumors and 41.7% of metastases. Intratumoral lymphocytic infiltrate was associated with lymph node metastasis. Patients with T3 tumors had better cancer-specific survival (CSS) than those with T4 tumors; patients with no lymph node involvement had better CSS than patients with N1 tumors. Undifferentiated tumors and hyperexpression of podoplanin were negative prognostic indicators on multivariate analysis.http://dx.doi.org/10.1155/2011/420796 |
| spellingShingle | de Lima Vazquez Vinicius Cristovam Scapulatempo Natalia Martins Perpetuo Faheez Mohamed Teóclito Sachetto de Carvalho Antônio Talvane Torres de Oliveira José Getúlio Martins Segalla André Lopes Carvalho Prognostic and Risk Factors in Patients with Locally Advanced Cutaneous Squamous Cell Carcinoma of the Trunk and Extremities Journal of Skin Cancer |
| title | Prognostic and Risk Factors in Patients with Locally Advanced Cutaneous Squamous Cell Carcinoma of the Trunk and Extremities |
| title_full | Prognostic and Risk Factors in Patients with Locally Advanced Cutaneous Squamous Cell Carcinoma of the Trunk and Extremities |
| title_fullStr | Prognostic and Risk Factors in Patients with Locally Advanced Cutaneous Squamous Cell Carcinoma of the Trunk and Extremities |
| title_full_unstemmed | Prognostic and Risk Factors in Patients with Locally Advanced Cutaneous Squamous Cell Carcinoma of the Trunk and Extremities |
| title_short | Prognostic and Risk Factors in Patients with Locally Advanced Cutaneous Squamous Cell Carcinoma of the Trunk and Extremities |
| title_sort | prognostic and risk factors in patients with locally advanced cutaneous squamous cell carcinoma of the trunk and extremities |
| url | http://dx.doi.org/10.1155/2011/420796 |
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