Emergent Biomarkers of Residual Cardiovascular Risk in Patients with Low HDL-c and/or High Triglycerides and Average LDL-c Concentrations: Focus on HDL Subpopulations, Oxidized LDL, Adiponectin, and Uric Acid
This study intended to determine the impact of HDL-c and/or TGs levels on patients with average LDL-c concentration, focusing on lipidic, oxidative, inflammatory, and angiogenic profiles. Patients with cardiovascular risk factors (n=169) were divided into 4 subgroups, combining normal and low HDL-c...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2013/387849 |
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| author | Filipa Mascarenhas-Melo Filipe Palavra Daniela Marado José Sereno Edite Teixeira-Lemos Isabel Freitas Maria Isabel-Mendonça Rui Pinto Frederico Teixeira Flávio Reis |
| author_facet | Filipa Mascarenhas-Melo Filipe Palavra Daniela Marado José Sereno Edite Teixeira-Lemos Isabel Freitas Maria Isabel-Mendonça Rui Pinto Frederico Teixeira Flávio Reis |
| author_sort | Filipa Mascarenhas-Melo |
| collection | DOAJ |
| description | This study intended to determine the impact of HDL-c and/or TGs levels on patients with average LDL-c concentration, focusing on lipidic, oxidative, inflammatory, and angiogenic profiles. Patients with cardiovascular risk factors (n=169) were divided into 4 subgroups, combining normal and low HDL-c with normal and high TGs patients. The following data was analyzed: BP, BMI, waist circumference and serum glucose, Total-c, TGs, LDL-c, oxidized-LDL, total HDL-c and HDL subpopulations, paraoxonase-1 (PON1) activity, hsCRP, uric acid, TNF-α, adiponectin, VEGF, and iCAM1. The two populations with increased TGs levels, regardless of the normal or low HDL-c, presented obesity and higher waist circumference, Total-c, LDL-c, Ox-LDL, and uric acid. Adiponectin concentration was significantly lower and VEGF was higher in the population with cumulative low values of HDL-c and high values of TGs, while HDL quality was reduced in the populations with impaired values of HDL-c and/or TGs, viewed by reduced large and increased small HDL subfractions. In conclusion, in a population with cardiovascular risk factors, low HDL-c and/or high TGs concentrations seem to be associated with a poor cardiometabolic profile, despite average LDL-c levels. This condition, often called residual risk, is better evidenced by using both traditional and nontraditional CV biomarkers, including large and small HDL subfractions, Ox-LDL, adiponectin, VEGF, and uric acid. |
| format | Article |
| id | doaj-art-7a055e5f17ab42aab1477c07f73f988d |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-7a055e5f17ab42aab1477c07f73f988d2025-02-03T05:43:36ZengWileyThe Scientific World Journal1537-744X2013-01-01201310.1155/2013/387849387849Emergent Biomarkers of Residual Cardiovascular Risk in Patients with Low HDL-c and/or High Triglycerides and Average LDL-c Concentrations: Focus on HDL Subpopulations, Oxidized LDL, Adiponectin, and Uric AcidFilipa Mascarenhas-Melo0Filipe Palavra1Daniela Marado2José Sereno3Edite Teixeira-Lemos4Isabel Freitas5Maria Isabel-Mendonça6Rui Pinto7Frederico Teixeira8Flávio Reis9Laboratory of Pharmacology & Experimental Therapeutics, IBILI, Faculty of Medicine, Sub-Unit 1 (Pólo III), University of Coimbra, 3000-548 Coimbra, PortugalNeurology Department, General Hospital, University and Hospital Centre of Coimbra, Quinta dos Vales, São Martinho do Bispo, 3041-801 Coimbra, PortugalInternal Medicine Department, General Hospital, University and Hospital Centre of Coimbra, Quinta dos Vales, São Martinho do Bispo, 3041-801 Coimbra, PortugalLaboratory of Pharmacology & Experimental Therapeutics, IBILI, Faculty of Medicine, Sub-Unit 1 (Pólo III), University of Coimbra, 3000-548 Coimbra, PortugalLaboratory of Pharmacology & Experimental Therapeutics, IBILI, Faculty of Medicine, Sub-Unit 1 (Pólo III), University of Coimbra, 3000-548 Coimbra, PortugalResearch Unit, Central Hospital of Funchal, 9004-514 Funchal, Madeira, PortugalResearch Unit, Central Hospital of Funchal, 9004-514 Funchal, Madeira, PortugalPharmacology and Pharmacotoxicology Unit, Faculty of Pharmacy, University of Lisbon, 1649-003 Lisbon, PortugalLaboratory of Pharmacology & Experimental Therapeutics, IBILI, Faculty of Medicine, Sub-Unit 1 (Pólo III), University of Coimbra, 3000-548 Coimbra, PortugalLaboratory of Pharmacology & Experimental Therapeutics, IBILI, Faculty of Medicine, Sub-Unit 1 (Pólo III), University of Coimbra, 3000-548 Coimbra, PortugalThis study intended to determine the impact of HDL-c and/or TGs levels on patients with average LDL-c concentration, focusing on lipidic, oxidative, inflammatory, and angiogenic profiles. Patients with cardiovascular risk factors (n=169) were divided into 4 subgroups, combining normal and low HDL-c with normal and high TGs patients. The following data was analyzed: BP, BMI, waist circumference and serum glucose, Total-c, TGs, LDL-c, oxidized-LDL, total HDL-c and HDL subpopulations, paraoxonase-1 (PON1) activity, hsCRP, uric acid, TNF-α, adiponectin, VEGF, and iCAM1. The two populations with increased TGs levels, regardless of the normal or low HDL-c, presented obesity and higher waist circumference, Total-c, LDL-c, Ox-LDL, and uric acid. Adiponectin concentration was significantly lower and VEGF was higher in the population with cumulative low values of HDL-c and high values of TGs, while HDL quality was reduced in the populations with impaired values of HDL-c and/or TGs, viewed by reduced large and increased small HDL subfractions. In conclusion, in a population with cardiovascular risk factors, low HDL-c and/or high TGs concentrations seem to be associated with a poor cardiometabolic profile, despite average LDL-c levels. This condition, often called residual risk, is better evidenced by using both traditional and nontraditional CV biomarkers, including large and small HDL subfractions, Ox-LDL, adiponectin, VEGF, and uric acid.http://dx.doi.org/10.1155/2013/387849 |
| spellingShingle | Filipa Mascarenhas-Melo Filipe Palavra Daniela Marado José Sereno Edite Teixeira-Lemos Isabel Freitas Maria Isabel-Mendonça Rui Pinto Frederico Teixeira Flávio Reis Emergent Biomarkers of Residual Cardiovascular Risk in Patients with Low HDL-c and/or High Triglycerides and Average LDL-c Concentrations: Focus on HDL Subpopulations, Oxidized LDL, Adiponectin, and Uric Acid The Scientific World Journal |
| title | Emergent Biomarkers of Residual Cardiovascular Risk in Patients with Low HDL-c and/or High Triglycerides and Average LDL-c Concentrations: Focus on HDL Subpopulations, Oxidized LDL, Adiponectin, and Uric Acid |
| title_full | Emergent Biomarkers of Residual Cardiovascular Risk in Patients with Low HDL-c and/or High Triglycerides and Average LDL-c Concentrations: Focus on HDL Subpopulations, Oxidized LDL, Adiponectin, and Uric Acid |
| title_fullStr | Emergent Biomarkers of Residual Cardiovascular Risk in Patients with Low HDL-c and/or High Triglycerides and Average LDL-c Concentrations: Focus on HDL Subpopulations, Oxidized LDL, Adiponectin, and Uric Acid |
| title_full_unstemmed | Emergent Biomarkers of Residual Cardiovascular Risk in Patients with Low HDL-c and/or High Triglycerides and Average LDL-c Concentrations: Focus on HDL Subpopulations, Oxidized LDL, Adiponectin, and Uric Acid |
| title_short | Emergent Biomarkers of Residual Cardiovascular Risk in Patients with Low HDL-c and/or High Triglycerides and Average LDL-c Concentrations: Focus on HDL Subpopulations, Oxidized LDL, Adiponectin, and Uric Acid |
| title_sort | emergent biomarkers of residual cardiovascular risk in patients with low hdl c and or high triglycerides and average ldl c concentrations focus on hdl subpopulations oxidized ldl adiponectin and uric acid |
| url | http://dx.doi.org/10.1155/2013/387849 |
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