Hepatoprotective effect of leaf extracts from Citrus hystrix and C. maxima against paracetamol induced liver injury in rats
The present investigation is aimed to evaluate the hepatoprotective effects of Citrus hystrix and Citrus maxima (Red and White variety) methanolic leaf extracts on paracetamol induced toxicity. Leaf extracts were given in the dose of 200 mg/kg body weight for 7 days and toxicity was induced by parac...
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Tsinghua University Press
2015-03-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453015000142 |
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| author | Arumugam Abirami Gunasekaran Nagarani Perumal Siddhuraju |
| author_facet | Arumugam Abirami Gunasekaran Nagarani Perumal Siddhuraju |
| author_sort | Arumugam Abirami |
| collection | DOAJ |
| description | The present investigation is aimed to evaluate the hepatoprotective effects of Citrus hystrix and Citrus maxima (Red and White variety) methanolic leaf extracts on paracetamol induced toxicity. Leaf extracts were given in the dose of 200 mg/kg body weight for 7 days and toxicity was induced by paracetamol (2 g/kg) on day 5. Silymarin (100 mg/kg body weight) was used as reference standard. On the 7th day animals were sacrificed and liver function markers (ALT, AST, ALP), total bilirubin and total protein in blood serums and hepatic antioxidants (SOD, CAT, GSH and GPx) in liver homogenate were estimated. The leaf extracts restored the liver function markers and hepatic antioxidants to the normal level than elevated levels noticed on paracetamol control at P < 0.001. Reversal of hepatoarchitecture has also been registered. The present study shows that C. hystrix and C. maxima leaf extracts possess hepatoprotective action against paracetamol induced hepatotoxicity. |
| format | Article |
| id | doaj-art-79fa5bcdf743400ab61b4f238ef744e2 |
| institution | Kabale University |
| issn | 2213-4530 |
| language | English |
| publishDate | 2015-03-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-79fa5bcdf743400ab61b4f238ef744e22025-02-03T06:49:13ZengTsinghua University PressFood Science and Human Wellness2213-45302015-03-0141354110.1016/j.fshw.2015.02.002Hepatoprotective effect of leaf extracts from Citrus hystrix and C. maxima against paracetamol induced liver injury in ratsArumugam AbiramiGunasekaran NagaraniPerumal SiddhurajuThe present investigation is aimed to evaluate the hepatoprotective effects of Citrus hystrix and Citrus maxima (Red and White variety) methanolic leaf extracts on paracetamol induced toxicity. Leaf extracts were given in the dose of 200 mg/kg body weight for 7 days and toxicity was induced by paracetamol (2 g/kg) on day 5. Silymarin (100 mg/kg body weight) was used as reference standard. On the 7th day animals were sacrificed and liver function markers (ALT, AST, ALP), total bilirubin and total protein in blood serums and hepatic antioxidants (SOD, CAT, GSH and GPx) in liver homogenate were estimated. The leaf extracts restored the liver function markers and hepatic antioxidants to the normal level than elevated levels noticed on paracetamol control at P < 0.001. Reversal of hepatoarchitecture has also been registered. The present study shows that C. hystrix and C. maxima leaf extracts possess hepatoprotective action against paracetamol induced hepatotoxicity.http://www.sciencedirect.com/science/article/pii/S2213453015000142Citrus hystrixCitrus maximaParacetamolSilymarinHepatoprotection |
| spellingShingle | Arumugam Abirami Gunasekaran Nagarani Perumal Siddhuraju Hepatoprotective effect of leaf extracts from Citrus hystrix and C. maxima against paracetamol induced liver injury in rats Food Science and Human Wellness Citrus hystrix Citrus maxima Paracetamol Silymarin Hepatoprotection |
| title | Hepatoprotective effect of leaf extracts from Citrus hystrix and C. maxima against paracetamol induced liver injury in rats |
| title_full | Hepatoprotective effect of leaf extracts from Citrus hystrix and C. maxima against paracetamol induced liver injury in rats |
| title_fullStr | Hepatoprotective effect of leaf extracts from Citrus hystrix and C. maxima against paracetamol induced liver injury in rats |
| title_full_unstemmed | Hepatoprotective effect of leaf extracts from Citrus hystrix and C. maxima against paracetamol induced liver injury in rats |
| title_short | Hepatoprotective effect of leaf extracts from Citrus hystrix and C. maxima against paracetamol induced liver injury in rats |
| title_sort | hepatoprotective effect of leaf extracts from citrus hystrix and c maxima against paracetamol induced liver injury in rats |
| topic | Citrus hystrix Citrus maxima Paracetamol Silymarin Hepatoprotection |
| url | http://www.sciencedirect.com/science/article/pii/S2213453015000142 |
| work_keys_str_mv | AT arumugamabirami hepatoprotectiveeffectofleafextractsfromcitrushystrixandcmaximaagainstparacetamolinducedliverinjuryinrats AT gunasekarannagarani hepatoprotectiveeffectofleafextractsfromcitrushystrixandcmaximaagainstparacetamolinducedliverinjuryinrats AT perumalsiddhuraju hepatoprotectiveeffectofleafextractsfromcitrushystrixandcmaximaagainstparacetamolinducedliverinjuryinrats |