Dietary Interventions and Physical Activity as Crucial Factors in the Prevention and Treatment of Metabolic Dysfunction-Associated Steatotic Liver Disease
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease worldwide and affects nearly 30% of the adult population and 10% of the pediatric population. It is estimated that this number will double by 2030. MASLD is one of the leading causes of hepatoce...
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2025-01-01
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| author | Paweł Rajewski Jakub Cieściński Piotr Rajewski Szymon Suwała Alicja Rajewska Maciej Potasz |
| author_facet | Paweł Rajewski Jakub Cieściński Piotr Rajewski Szymon Suwała Alicja Rajewska Maciej Potasz |
| author_sort | Paweł Rajewski |
| collection | DOAJ |
| description | Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease worldwide and affects nearly 30% of the adult population and 10% of the pediatric population. It is estimated that this number will double by 2030. MASLD is one of the leading causes of hepatocellular carcinoma, cirrhosis, and liver transplantation, as well as a significant risk factor for cardiovascular disease and mortality. Due to the ever-increasing number of patients, the long-term asymptomatic course of the disease, serious complications, and lack of preventive programs, as well as insufficient awareness of the disease among patients and doctors themselves, MASLD is a growing interdisciplinary problem and a real challenge for modern medicine. The main cause of MASLD is an inappropriate lifestyle—inadequate nutrition and insufficient physical activity, which lead to various components of metabolic syndrome. Lifestyle changes—appropriate diet, weight reduction, and systematic physical activity—are also the basis for the prevention and treatment of MASLD. Hence, in recent years, so much importance has been attached to lifestyle medicine, to non-pharmacological treatment as prevention of lifestyle diseases. The narrative review presents possible therapeutic options for non-pharmacological management in the prevention and treatment of MASLD. The best documented and available diets used in MASLD were discussed, focusing on the benefits and drawbacks of the Mediterranean, high-protein, ketogenic, and intermittent fasting diets. In addition, the most recent recommendations regarding physical activity are summarized. |
| format | Article |
| id | doaj-art-79f511c1782c41e385a3484c32c7cc97 |
| institution | Kabale University |
| issn | 2227-9059 |
| language | English |
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| publisher | MDPI AG |
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| spelling | doaj-art-79f511c1782c41e385a3484c32c7cc972025-01-24T13:24:26ZengMDPI AGBiomedicines2227-90592025-01-0113121710.3390/biomedicines13010217Dietary Interventions and Physical Activity as Crucial Factors in the Prevention and Treatment of Metabolic Dysfunction-Associated Steatotic Liver DiseasePaweł Rajewski0Jakub Cieściński1Piotr Rajewski2Szymon Suwała3Alicja Rajewska4Maciej Potasz5Department of Internal and Infectious Diseases, Provincial Infectious Disease Hospital, 85-030 Bydgoszcz, PolandDepartment of Radiology, Provincial Infectious Disease Hospital, 85-030 Bydgoszcz, PolandDepartment of Neurology, Collegium Medicum—Faculty of Medicine, Nicolaus Copernicus University in Toruń, 85-094 Bygoszcz, PolandDepartment of Endocrinology and Diabetology, Collegium Medicum—Faculty of Medicine, Nicolaus Copernicus University in Toruń, 85-094 Bydgoszcz, PolandUniversity Clinical Hospital, 60-355 Poznań, PolandUniversity Clinical Hospital, 60-355 Poznań, PolandMetabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease worldwide and affects nearly 30% of the adult population and 10% of the pediatric population. It is estimated that this number will double by 2030. MASLD is one of the leading causes of hepatocellular carcinoma, cirrhosis, and liver transplantation, as well as a significant risk factor for cardiovascular disease and mortality. Due to the ever-increasing number of patients, the long-term asymptomatic course of the disease, serious complications, and lack of preventive programs, as well as insufficient awareness of the disease among patients and doctors themselves, MASLD is a growing interdisciplinary problem and a real challenge for modern medicine. The main cause of MASLD is an inappropriate lifestyle—inadequate nutrition and insufficient physical activity, which lead to various components of metabolic syndrome. Lifestyle changes—appropriate diet, weight reduction, and systematic physical activity—are also the basis for the prevention and treatment of MASLD. Hence, in recent years, so much importance has been attached to lifestyle medicine, to non-pharmacological treatment as prevention of lifestyle diseases. The narrative review presents possible therapeutic options for non-pharmacological management in the prevention and treatment of MASLD. The best documented and available diets used in MASLD were discussed, focusing on the benefits and drawbacks of the Mediterranean, high-protein, ketogenic, and intermittent fasting diets. In addition, the most recent recommendations regarding physical activity are summarized.https://www.mdpi.com/2227-9059/13/1/217lifestyleMASLDnon-pharmacological treatmentdietphysical activityhepatic steatosis |
| spellingShingle | Paweł Rajewski Jakub Cieściński Piotr Rajewski Szymon Suwała Alicja Rajewska Maciej Potasz Dietary Interventions and Physical Activity as Crucial Factors in the Prevention and Treatment of Metabolic Dysfunction-Associated Steatotic Liver Disease Biomedicines lifestyle MASLD non-pharmacological treatment diet physical activity hepatic steatosis |
| title | Dietary Interventions and Physical Activity as Crucial Factors in the Prevention and Treatment of Metabolic Dysfunction-Associated Steatotic Liver Disease |
| title_full | Dietary Interventions and Physical Activity as Crucial Factors in the Prevention and Treatment of Metabolic Dysfunction-Associated Steatotic Liver Disease |
| title_fullStr | Dietary Interventions and Physical Activity as Crucial Factors in the Prevention and Treatment of Metabolic Dysfunction-Associated Steatotic Liver Disease |
| title_full_unstemmed | Dietary Interventions and Physical Activity as Crucial Factors in the Prevention and Treatment of Metabolic Dysfunction-Associated Steatotic Liver Disease |
| title_short | Dietary Interventions and Physical Activity as Crucial Factors in the Prevention and Treatment of Metabolic Dysfunction-Associated Steatotic Liver Disease |
| title_sort | dietary interventions and physical activity as crucial factors in the prevention and treatment of metabolic dysfunction associated steatotic liver disease |
| topic | lifestyle MASLD non-pharmacological treatment diet physical activity hepatic steatosis |
| url | https://www.mdpi.com/2227-9059/13/1/217 |
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