Updates in Reproduction Coming from the Endocannabinoid System
The endocannabinoid system (ECS) is an evolutionarily conserved master system deeply involved in the central and local control of reproductive functions in both sexes. The tone of these lipid mediators—deeply modulated by the activity of biosynthetic and hydrolyzing machineries—regulates reproductiv...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2014/412354 |
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| _version_ | 1832553475631742976 |
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| author | Rosaria Meccariello Natalia Battista Heather B. Bradshaw Haibin Wang |
| author_facet | Rosaria Meccariello Natalia Battista Heather B. Bradshaw Haibin Wang |
| author_sort | Rosaria Meccariello |
| collection | DOAJ |
| description | The endocannabinoid system (ECS) is an evolutionarily conserved master system deeply involved in the central and local control of reproductive functions in both sexes. The tone of these lipid mediators—deeply modulated by the activity of biosynthetic and hydrolyzing machineries—regulates reproductive functions from gonadotropin discharge and steroid biosynthesis to the formation of high quality gametes and successful pregnancy. This review provides an overview on ECS and reproduction and focuses on the insights in the regulation of endocannabinoid production by steroids, in the regulation of male reproductive activity, and in placentation and parturition. Taken all together, evidences emerge that the activity of the ECS is crucial for procreation and may represent a target for the therapeutic exploitation of infertility. |
| format | Article |
| id | doaj-art-79f4be1bacbe4abb83aa45617d3cd291 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-79f4be1bacbe4abb83aa45617d3cd2912025-02-03T05:53:50ZengWileyInternational Journal of Endocrinology1687-83371687-83452014-01-01201410.1155/2014/412354412354Updates in Reproduction Coming from the Endocannabinoid SystemRosaria Meccariello0Natalia Battista1Heather B. Bradshaw2Haibin Wang3Dipartimento di Scienze Motorie e del Benessere, Università di Napoli Parthenope, via Medina 40, 80133 Napoli, ItalyFaculty of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, 64100 Teramo, ItalyDepartment of Psychological and Brain Sciences, The Kinsey Institute for Research in Sex, Gender, and Reproduction, Indiana University, Bloomington, IN 47405, USAState Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, ChinaThe endocannabinoid system (ECS) is an evolutionarily conserved master system deeply involved in the central and local control of reproductive functions in both sexes. The tone of these lipid mediators—deeply modulated by the activity of biosynthetic and hydrolyzing machineries—regulates reproductive functions from gonadotropin discharge and steroid biosynthesis to the formation of high quality gametes and successful pregnancy. This review provides an overview on ECS and reproduction and focuses on the insights in the regulation of endocannabinoid production by steroids, in the regulation of male reproductive activity, and in placentation and parturition. Taken all together, evidences emerge that the activity of the ECS is crucial for procreation and may represent a target for the therapeutic exploitation of infertility.http://dx.doi.org/10.1155/2014/412354 |
| spellingShingle | Rosaria Meccariello Natalia Battista Heather B. Bradshaw Haibin Wang Updates in Reproduction Coming from the Endocannabinoid System International Journal of Endocrinology |
| title | Updates in Reproduction Coming from the Endocannabinoid System |
| title_full | Updates in Reproduction Coming from the Endocannabinoid System |
| title_fullStr | Updates in Reproduction Coming from the Endocannabinoid System |
| title_full_unstemmed | Updates in Reproduction Coming from the Endocannabinoid System |
| title_short | Updates in Reproduction Coming from the Endocannabinoid System |
| title_sort | updates in reproduction coming from the endocannabinoid system |
| url | http://dx.doi.org/10.1155/2014/412354 |
| work_keys_str_mv | AT rosariameccariello updatesinreproductioncomingfromtheendocannabinoidsystem AT nataliabattista updatesinreproductioncomingfromtheendocannabinoidsystem AT heatherbbradshaw updatesinreproductioncomingfromtheendocannabinoidsystem AT haibinwang updatesinreproductioncomingfromtheendocannabinoidsystem |