Prognostic value of c-MET in oesophageal squamous cell carcinoma: a study based on the mRNA expression in TCGA database and a meta-analysis
ObjectiveThis study aims to assess the mesenchymal-epithelial transition factor’s (c-MET) prognostic value in oesophageal carcinoma (ESCA) through a meta-analysis and bioinformatics.MethodsWe analysed c-MET expression in ESCA tissues using data from The Cancer Genome Atlas (TCGA) and conducted a met...
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Frontiers Media S.A.
2025-02-01
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2025.1548160/full |
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| author | Qiqi Zhang Xiujuan Li Jian Li Zhiqiang Zhang |
| author_facet | Qiqi Zhang Xiujuan Li Jian Li Zhiqiang Zhang |
| author_sort | Qiqi Zhang |
| collection | DOAJ |
| description | ObjectiveThis study aims to assess the mesenchymal-epithelial transition factor’s (c-MET) prognostic value in oesophageal carcinoma (ESCA) through a meta-analysis and bioinformatics.MethodsWe analysed c-MET expression in ESCA tissues using data from The Cancer Genome Atlas (TCGA) and conducted a meta-analysis to evaluate its association with clinicopathological factors and survival outcomes. The meta-analysis included studies reporting hazard ratios (HRs) and odds ratios (ORs) for survival and metastatic outcomes.ResultsThe Cancer Genome Atlas analysis revealed elevated c-MET expression in ESCA, which was significantly correlated with lymph node metastasis, tumour grade and stage, though not with overall survival (OS). In the meta-analysis, 278 publications were identified, and 89 duplicates were removed. After screening, 176 articles were excluded, leaving 13 for full-text review. Of these, 5 studies lacked sufficient survival data, resulting in 8 eligible studies with a total of 1,488 patients. Meta-analysis findings indicated that high c-MET expression was associated with worse OS (HR = 1.54, 95% confidence interval [CI]: 1.17–2.01; p = 0.002), distant metastasis (OR = 1.97, 95% CI: 1.14–3.40; p = 0.02) and advanced stage (OR = 2.23, 95% CI: 1.41–3.53; p = 0.0006).ConclusionHigh c-MET expression is associated with poor prognosis and advanced disease in ESCA, highlighting its potential as a biomarker for risk stratification. Further studies are needed to confirm its prognostic value and explore therapeutic implications. |
| format | Article |
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| institution | DOAJ |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-02-01 |
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| series | Frontiers in Medicine |
| spelling | doaj-art-79ea017c3cd74acdb4e1b1a37b7d8ec22025-08-20T02:45:38ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-02-011210.3389/fmed.2025.15481601548160Prognostic value of c-MET in oesophageal squamous cell carcinoma: a study based on the mRNA expression in TCGA database and a meta-analysisQiqi Zhang0Xiujuan Li1Jian Li2Zhiqiang Zhang3Department of Gastroenterology II, The First Affiliated Hospital of Xinjiang Medical University, State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Urumqi, ChinaDepartment of Pathophysiology, School of Basic Medical Sciences, Xinjiang Medical University, Urumqi, ChinaDepartment of Gastroenterology II, The First Affiliated Hospital of Xinjiang Medical University, State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Urumqi, ChinaDepartment of Gastroenterology II, The First Affiliated Hospital of Xinjiang Medical University, State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Urumqi, ChinaObjectiveThis study aims to assess the mesenchymal-epithelial transition factor’s (c-MET) prognostic value in oesophageal carcinoma (ESCA) through a meta-analysis and bioinformatics.MethodsWe analysed c-MET expression in ESCA tissues using data from The Cancer Genome Atlas (TCGA) and conducted a meta-analysis to evaluate its association with clinicopathological factors and survival outcomes. The meta-analysis included studies reporting hazard ratios (HRs) and odds ratios (ORs) for survival and metastatic outcomes.ResultsThe Cancer Genome Atlas analysis revealed elevated c-MET expression in ESCA, which was significantly correlated with lymph node metastasis, tumour grade and stage, though not with overall survival (OS). In the meta-analysis, 278 publications were identified, and 89 duplicates were removed. After screening, 176 articles were excluded, leaving 13 for full-text review. Of these, 5 studies lacked sufficient survival data, resulting in 8 eligible studies with a total of 1,488 patients. Meta-analysis findings indicated that high c-MET expression was associated with worse OS (HR = 1.54, 95% confidence interval [CI]: 1.17–2.01; p = 0.002), distant metastasis (OR = 1.97, 95% CI: 1.14–3.40; p = 0.02) and advanced stage (OR = 2.23, 95% CI: 1.41–3.53; p = 0.0006).ConclusionHigh c-MET expression is associated with poor prognosis and advanced disease in ESCA, highlighting its potential as a biomarker for risk stratification. Further studies are needed to confirm its prognostic value and explore therapeutic implications.https://www.frontiersin.org/articles/10.3389/fmed.2025.1548160/fullproto-oncogene proteins mesenchymal-epithelial transition factoroesophageal squamous cell carcinomaprognosismeta-analysisbiomarkers |
| spellingShingle | Qiqi Zhang Xiujuan Li Jian Li Zhiqiang Zhang Prognostic value of c-MET in oesophageal squamous cell carcinoma: a study based on the mRNA expression in TCGA database and a meta-analysis Frontiers in Medicine proto-oncogene proteins mesenchymal-epithelial transition factor oesophageal squamous cell carcinoma prognosis meta-analysis biomarkers |
| title | Prognostic value of c-MET in oesophageal squamous cell carcinoma: a study based on the mRNA expression in TCGA database and a meta-analysis |
| title_full | Prognostic value of c-MET in oesophageal squamous cell carcinoma: a study based on the mRNA expression in TCGA database and a meta-analysis |
| title_fullStr | Prognostic value of c-MET in oesophageal squamous cell carcinoma: a study based on the mRNA expression in TCGA database and a meta-analysis |
| title_full_unstemmed | Prognostic value of c-MET in oesophageal squamous cell carcinoma: a study based on the mRNA expression in TCGA database and a meta-analysis |
| title_short | Prognostic value of c-MET in oesophageal squamous cell carcinoma: a study based on the mRNA expression in TCGA database and a meta-analysis |
| title_sort | prognostic value of c met in oesophageal squamous cell carcinoma a study based on the mrna expression in tcga database and a meta analysis |
| topic | proto-oncogene proteins mesenchymal-epithelial transition factor oesophageal squamous cell carcinoma prognosis meta-analysis biomarkers |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2025.1548160/full |
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