Prognostic value of c-MET in oesophageal squamous cell carcinoma: a study based on the mRNA expression in TCGA database and a meta-analysis
ObjectiveThis study aims to assess the mesenchymal-epithelial transition factor’s (c-MET) prognostic value in oesophageal carcinoma (ESCA) through a meta-analysis and bioinformatics.MethodsWe analysed c-MET expression in ESCA tissues using data from The Cancer Genome Atlas (TCGA) and conducted a met...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2025.1548160/full |
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| Summary: | ObjectiveThis study aims to assess the mesenchymal-epithelial transition factor’s (c-MET) prognostic value in oesophageal carcinoma (ESCA) through a meta-analysis and bioinformatics.MethodsWe analysed c-MET expression in ESCA tissues using data from The Cancer Genome Atlas (TCGA) and conducted a meta-analysis to evaluate its association with clinicopathological factors and survival outcomes. The meta-analysis included studies reporting hazard ratios (HRs) and odds ratios (ORs) for survival and metastatic outcomes.ResultsThe Cancer Genome Atlas analysis revealed elevated c-MET expression in ESCA, which was significantly correlated with lymph node metastasis, tumour grade and stage, though not with overall survival (OS). In the meta-analysis, 278 publications were identified, and 89 duplicates were removed. After screening, 176 articles were excluded, leaving 13 for full-text review. Of these, 5 studies lacked sufficient survival data, resulting in 8 eligible studies with a total of 1,488 patients. Meta-analysis findings indicated that high c-MET expression was associated with worse OS (HR = 1.54, 95% confidence interval [CI]: 1.17–2.01; p = 0.002), distant metastasis (OR = 1.97, 95% CI: 1.14–3.40; p = 0.02) and advanced stage (OR = 2.23, 95% CI: 1.41–3.53; p = 0.0006).ConclusionHigh c-MET expression is associated with poor prognosis and advanced disease in ESCA, highlighting its potential as a biomarker for risk stratification. Further studies are needed to confirm its prognostic value and explore therapeutic implications. |
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| ISSN: | 2296-858X |