Chlorogenic acid alleviates cadmium-induced neuronal injury in chicken cerebral cortex by inhibiting incomplete autophagy mediated by AMPK-ULK1 pathway
Cadmium (Cd) is an environmental pollutant that has neurotoxic properties, which poses serious threats to human health and the development of poultry farming. Chlorogenic acid (CGA) is a dietary polyphenol exhibit various biological activities such as antioxidant, anti-inflammatory, and autophagy re...
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| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-01-01
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| Series: | Poultry Science |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0032579124011751 |
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| Summary: | Cadmium (Cd) is an environmental pollutant that has neurotoxic properties, which poses serious threats to human health and the development of poultry farming. Chlorogenic acid (CGA) is a dietary polyphenol exhibit various biological activities such as antioxidant, anti-inflammatory, and autophagy regulation. In addition, CGA can penetrate the blood-brain barrier and exert neuroprotective effects. This study explored the mechanism of CGA in alleviating Cd-induced cerebral cortical neuron injury in chickens. The results showed that in vivo, CGA reduced the Cd level and alleviated Cd-induced histopathological and ultrastructural damages in the chicken cerebral cortex. Further research has found that CGA alleviated Cd-induced incomplete autophagy and activation of the AMPK-ULK1 pathway. In vitro, AMPK inhibitors (Compound C) could alleviate Cd-induced incomplete autophagy in chicken cerebral cortical neurons. In addition, CGA alleviated the decreased viability, incomplete autophagy, and activation of the AMPK-ULK1 pathway induced by Cd in chicken cerebral cortical neurons. In summary, CGA can alleviate Cd-induced cerebral cortical neuron injury in chickens, which is related to CGA alleviating Cd-induced incomplete autophagy by inhibiting the AMPK-ULK1 pathway. |
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| ISSN: | 0032-5791 |