Protective efficacy of classical vaccines and vaccination protocols against an exotic Newcastle disease virus genotype VII.2 in Belgian layer and broiler chickens
Vaccination against Newcastle disease (ND) has been routinely implemented in the Belgian professional poultry sector since 1993, using genotype I and II vaccines. Despite this, an outbreak of genotype VII.2 avian paramyx-ovirus 1 (APMV-1) occurred in 2018, with 20 reported cases over the course of 3...
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Elsevier
2025-01-01
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| Series: | Poultry Science |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0032579124011829 |
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| author | Mieke Steensels Colas Soldan Fabienne Rauw Virginie Roupie Bénédicte Lambrecht |
| author_facet | Mieke Steensels Colas Soldan Fabienne Rauw Virginie Roupie Bénédicte Lambrecht |
| author_sort | Mieke Steensels |
| collection | DOAJ |
| description | Vaccination against Newcastle disease (ND) has been routinely implemented in the Belgian professional poultry sector since 1993, using genotype I and II vaccines. Despite this, an outbreak of genotype VII.2 avian paramyx-ovirus 1 (APMV-1) occurred in 2018, with 20 reported cases over the course of 3 months. Although the economic impact on the professional poultry sector was limited, this epizootic raised questions regarding the efficacy of implemented classical genotype I and II vaccines against phylogenetically distant exotic velogenic strains.The present study provides insights into the protective efficacy of standard vaccination programs applied in layer and broiler flocks against the introduction and transmission of this velogenic APMV-1 VII.2 strain.For fully field-vaccinated 26-week-old layer chickens, high levels of specific antibodies were measured at the time of the velogenic APMV-1 challenge, resulting in good clinical protection. However, despite the observed humoral immunity, viral excretion was not prevented, leading to transmission of the virus to non-infected sentinel birds.In fully field-vaccinated 4-week-old broiler chickens, assessment of vaccine uptake and coverage revealed low levels of ND specific antibodies despite double vaccination at day 1 and day 14. Consequently, poor protection against velogenic APMV-1 infection was observed, with both clinical signs and viral excretion occurring in both infected and sentinel birds.This study demonstrates that the introduction of velogenic APMV-1 VII.2 can lead to its dissemination among the Belgian avian poultry population despite the implementation of standard vaccination. |
| format | Article |
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| institution | Kabale University |
| issn | 0032-5791 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
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| spelling | doaj-art-79ced667d3d64809af0301e4b3e5568d2025-01-22T05:40:40ZengElsevierPoultry Science0032-57912025-01-011041104604Protective efficacy of classical vaccines and vaccination protocols against an exotic Newcastle disease virus genotype VII.2 in Belgian layer and broiler chickensMieke Steensels0Colas Soldan1Fabienne Rauw2Virginie Roupie3Bénédicte Lambrecht4Avian Virology and Immunology, Sciensano, Rue Groeselenberg 99, Uccle, Brussels 1180, Belgium; Corresponding author.Avian Virology and Immunology, Sciensano, Rue Groeselenberg 99, Uccle, Brussels 1180, Belgium; Laboratory of Virology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, BelgiumAvian Virology and Immunology, Sciensano, Rue Groeselenberg 99, Uccle, Brussels 1180, BelgiumAvian Virology and Immunology, Sciensano, Rue Groeselenberg 99, Uccle, Brussels 1180, BelgiumAvian Virology and Immunology, Sciensano, Rue Groeselenberg 99, Uccle, Brussels 1180, BelgiumVaccination against Newcastle disease (ND) has been routinely implemented in the Belgian professional poultry sector since 1993, using genotype I and II vaccines. Despite this, an outbreak of genotype VII.2 avian paramyx-ovirus 1 (APMV-1) occurred in 2018, with 20 reported cases over the course of 3 months. Although the economic impact on the professional poultry sector was limited, this epizootic raised questions regarding the efficacy of implemented classical genotype I and II vaccines against phylogenetically distant exotic velogenic strains.The present study provides insights into the protective efficacy of standard vaccination programs applied in layer and broiler flocks against the introduction and transmission of this velogenic APMV-1 VII.2 strain.For fully field-vaccinated 26-week-old layer chickens, high levels of specific antibodies were measured at the time of the velogenic APMV-1 challenge, resulting in good clinical protection. However, despite the observed humoral immunity, viral excretion was not prevented, leading to transmission of the virus to non-infected sentinel birds.In fully field-vaccinated 4-week-old broiler chickens, assessment of vaccine uptake and coverage revealed low levels of ND specific antibodies despite double vaccination at day 1 and day 14. Consequently, poor protection against velogenic APMV-1 infection was observed, with both clinical signs and viral excretion occurring in both infected and sentinel birds.This study demonstrates that the introduction of velogenic APMV-1 VII.2 can lead to its dissemination among the Belgian avian poultry population despite the implementation of standard vaccination.http://www.sciencedirect.com/science/article/pii/S0032579124011829Newcastle disease virusGenotype VII.2Classical vaccinationLayerBroiler |
| spellingShingle | Mieke Steensels Colas Soldan Fabienne Rauw Virginie Roupie Bénédicte Lambrecht Protective efficacy of classical vaccines and vaccination protocols against an exotic Newcastle disease virus genotype VII.2 in Belgian layer and broiler chickens Poultry Science Newcastle disease virus Genotype VII.2 Classical vaccination Layer Broiler |
| title | Protective efficacy of classical vaccines and vaccination protocols against an exotic Newcastle disease virus genotype VII.2 in Belgian layer and broiler chickens |
| title_full | Protective efficacy of classical vaccines and vaccination protocols against an exotic Newcastle disease virus genotype VII.2 in Belgian layer and broiler chickens |
| title_fullStr | Protective efficacy of classical vaccines and vaccination protocols against an exotic Newcastle disease virus genotype VII.2 in Belgian layer and broiler chickens |
| title_full_unstemmed | Protective efficacy of classical vaccines and vaccination protocols against an exotic Newcastle disease virus genotype VII.2 in Belgian layer and broiler chickens |
| title_short | Protective efficacy of classical vaccines and vaccination protocols against an exotic Newcastle disease virus genotype VII.2 in Belgian layer and broiler chickens |
| title_sort | protective efficacy of classical vaccines and vaccination protocols against an exotic newcastle disease virus genotype vii 2 in belgian layer and broiler chickens |
| topic | Newcastle disease virus Genotype VII.2 Classical vaccination Layer Broiler |
| url | http://www.sciencedirect.com/science/article/pii/S0032579124011829 |
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