Severe Gastrooesophageal Reflux Disease Associated with Foetal Alcohol Syndrome
Prenatal alcohol exposure may have adverse effects on the developing foetus resulting in significant growth restriction, characteristic craniofacial features, and central nervous system dysfunction. The toxic effects of alcohol on the developing brain are well recognised. However, little is known ab...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Case Reports in Pediatrics |
| Online Access: | http://dx.doi.org/10.1155/2012/509253 |
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| author | N. K. Sujay Matthew Jones Emma Whittle Helen Murphy Marcus K. H. Auth |
| author_facet | N. K. Sujay Matthew Jones Emma Whittle Helen Murphy Marcus K. H. Auth |
| author_sort | N. K. Sujay |
| collection | DOAJ |
| description | Prenatal alcohol exposure may have adverse effects on the developing foetus resulting in significant growth restriction, characteristic craniofacial features, and central nervous system dysfunction. The toxic effects of alcohol on the developing brain are well recognised. However, little is known about the effects of alcohol on the developing gastrointestinal tract or their mechanism. There are few case reports showing an association between foetal alcohol syndrome and gastrointestinal neuropathy. We report a rare association between foetal alcohol syndrome and severe gastrooesophageal reflux disease in an infant who ultimately required fundoplication to optimise her growth and nutrition. The child had failed to respond to maximal medical treatment (domperidone and omeprazole), high calorie feeds, PEG feeding, or total parenteral nutrition. The effect of alcohol on the developing foetus is not limited to the central nervous system but also can have varied and devastating effects on the gastrointestinal tract. |
| format | Article |
| id | doaj-art-79ca725a6ccd4a3bb8ac23e6c1458543 |
| institution | Kabale University |
| issn | 2090-6803 2090-6811 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pediatrics |
| spelling | doaj-art-79ca725a6ccd4a3bb8ac23e6c14585432025-02-03T01:11:32ZengWileyCase Reports in Pediatrics2090-68032090-68112012-01-01201210.1155/2012/509253509253Severe Gastrooesophageal Reflux Disease Associated with Foetal Alcohol SyndromeN. K. Sujay0Matthew Jones1Emma Whittle2Helen Murphy3Marcus K. H. Auth4Department of Paediatric Gastroenterology, Alder Hey Children’s NHS Foundation Trust, Liverpool L12 2AP, UKDepartment of Paediatric General Surgery, Alder Hey Children’s NHS Foundation Trust, Liverpool L12 2AP, UKDepartment of Paediatric Dietetics, Alder Hey Children’s NHS Foundation Trust, Liverpool L12 2AP, UKDepartment of Clinical Genetics, Liverpool Women’s NHS Foundation Trust, Liverpool L8 7SS, UKDepartment of Paediatric Gastroenterology, Alder Hey Children’s NHS Foundation Trust, Liverpool L12 2AP, UKPrenatal alcohol exposure may have adverse effects on the developing foetus resulting in significant growth restriction, characteristic craniofacial features, and central nervous system dysfunction. The toxic effects of alcohol on the developing brain are well recognised. However, little is known about the effects of alcohol on the developing gastrointestinal tract or their mechanism. There are few case reports showing an association between foetal alcohol syndrome and gastrointestinal neuropathy. We report a rare association between foetal alcohol syndrome and severe gastrooesophageal reflux disease in an infant who ultimately required fundoplication to optimise her growth and nutrition. The child had failed to respond to maximal medical treatment (domperidone and omeprazole), high calorie feeds, PEG feeding, or total parenteral nutrition. The effect of alcohol on the developing foetus is not limited to the central nervous system but also can have varied and devastating effects on the gastrointestinal tract.http://dx.doi.org/10.1155/2012/509253 |
| spellingShingle | N. K. Sujay Matthew Jones Emma Whittle Helen Murphy Marcus K. H. Auth Severe Gastrooesophageal Reflux Disease Associated with Foetal Alcohol Syndrome Case Reports in Pediatrics |
| title | Severe Gastrooesophageal Reflux Disease Associated with Foetal Alcohol Syndrome |
| title_full | Severe Gastrooesophageal Reflux Disease Associated with Foetal Alcohol Syndrome |
| title_fullStr | Severe Gastrooesophageal Reflux Disease Associated with Foetal Alcohol Syndrome |
| title_full_unstemmed | Severe Gastrooesophageal Reflux Disease Associated with Foetal Alcohol Syndrome |
| title_short | Severe Gastrooesophageal Reflux Disease Associated with Foetal Alcohol Syndrome |
| title_sort | severe gastrooesophageal reflux disease associated with foetal alcohol syndrome |
| url | http://dx.doi.org/10.1155/2012/509253 |
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