NGF, Brain and Behavioral Plasticity
Nerve Growth Factor (NGF) was initially studied for its role as a key player in the regulation of peripheral innervations. However, the successive finding of its release in the bloodstream of male mice following aggressive encounters and its presence in the central nervous system led to the hypothes...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2012/784040 |
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| _version_ | 1832548467862405120 |
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| author | Alessandra Berry Erika Bindocci Enrico Alleva |
| author_facet | Alessandra Berry Erika Bindocci Enrico Alleva |
| author_sort | Alessandra Berry |
| collection | DOAJ |
| description | Nerve Growth Factor (NGF) was initially studied for its role as a key player in the regulation of peripheral innervations. However, the successive finding of its release in the bloodstream of male mice following aggressive encounters and its presence in the central nervous system led to the hypothesis that variations in brain NGF levels, caused by psychosocial stressor, and the related alterations in emotionality, could be functional to the development of proper strategies to cope with the stressor itself and thus to survive. Years later this vision is still relevant, and the body of evidence on the role of NGF has been strengthened and expanded from trophic factor playing a role in brain growth and differentiation to a much more complex messenger, involved in psychoneuroendocrine plasticity. |
| format | Article |
| id | doaj-art-79c214d553f94aebb39a1fba79340a62 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-79c214d553f94aebb39a1fba79340a622025-02-03T06:14:04ZengWileyNeural Plasticity2090-59041687-54432012-01-01201210.1155/2012/784040784040NGF, Brain and Behavioral PlasticityAlessandra Berry0Erika Bindocci1Enrico Alleva2Section of Behavioral Neurosciences, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, ItalySection of Behavioral Neurosciences, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, ItalySection of Behavioral Neurosciences, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, ItalyNerve Growth Factor (NGF) was initially studied for its role as a key player in the regulation of peripheral innervations. However, the successive finding of its release in the bloodstream of male mice following aggressive encounters and its presence in the central nervous system led to the hypothesis that variations in brain NGF levels, caused by psychosocial stressor, and the related alterations in emotionality, could be functional to the development of proper strategies to cope with the stressor itself and thus to survive. Years later this vision is still relevant, and the body of evidence on the role of NGF has been strengthened and expanded from trophic factor playing a role in brain growth and differentiation to a much more complex messenger, involved in psychoneuroendocrine plasticity.http://dx.doi.org/10.1155/2012/784040 |
| spellingShingle | Alessandra Berry Erika Bindocci Enrico Alleva NGF, Brain and Behavioral Plasticity Neural Plasticity |
| title | NGF, Brain and Behavioral Plasticity |
| title_full | NGF, Brain and Behavioral Plasticity |
| title_fullStr | NGF, Brain and Behavioral Plasticity |
| title_full_unstemmed | NGF, Brain and Behavioral Plasticity |
| title_short | NGF, Brain and Behavioral Plasticity |
| title_sort | ngf brain and behavioral plasticity |
| url | http://dx.doi.org/10.1155/2012/784040 |
| work_keys_str_mv | AT alessandraberry ngfbrainandbehavioralplasticity AT erikabindocci ngfbrainandbehavioralplasticity AT enricoalleva ngfbrainandbehavioralplasticity |