Genetic regulation of liver lipids in a mouse model of insulin resistance and hepatic steatosis

Genetic regulation of liver lipids in a mouse model of insulin resistance and hepatic steatosis

Abstract To elucidate the contributions of specific lipid species to metabolic traits, we integrated global hepatic lipid data with other omics measures and genetic data from a cohort of about 100 diverse inbred strains of mice fed a high‐fat/high‐sucrose diet for 8 weeks. Association mapping, corre...

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Bibliographic Details
Main Authors: Frode Norheim, Karthickeyan Chella Krishnan, Thomas Bjellaas, Laurent Vergnes, Calvin Pan, Brian W Parks, Yonghong Meng, Jennifer Lang, James A Ward, Karen Reue, Margarete Mehrabian, Thomas E Gundersen, Miklós Péterfy, Knut T Dalen, Christian A Drevon, Simon T Hui, Aldons J Lusis, Marcus M Seldin
Format: Article
Language:English
Published: Springer Nature 2021-01-01
Series:Molecular Systems Biology
Subjects:
genome‐wide association studies
hepatic lipidome
Hybrid Mouse Diversity Panel
non‐alcoholic fatty liver disease
quantitative trait loci for lipids
Online Access:https://doi.org/10.15252/msb.20209684
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