Alveolar epithelial and vascular CXCR2 mediates transcytosis of CXCL1 in inflamed lungs

Alveolar epithelial and vascular CXCR2 mediates transcytosis of CXCL1 in inflamed lungs

Abstract Pulmonary infections are characterized by neutrophil recruitment into the lung driven by chemokine ligands of CXCR2, which is expressed on neutrophils, but also present in non-hematopoietic lung cells, in which its role remains unclear. We hypothesize that CXCR2 in epithelial and endothelia...

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Main Authors: Katharina Thomas, Jan Rossaint, Nadine Ludwig, Sina Mersmann, Niklas Kötting, Julia Grenzheuser, Lena Schemmelmann, Marina Oguama, Andreas Margraf, Helena Block, Katharina Henke, Katharina Hellenthal, Valbona Mirakaj, Volker Gerke, Uwe Hansen, Karin Gäher, Miguel Engelhardt, Johannes Roth, Johannes Eble, Elin Hub, Antal Rot, Ronen Alon, Alexander Zarbock
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60174-w
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https://doi.org/10.1038/s41467-025-60174-w

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